Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets

por Bowler, Jeannette T., Sawaya, Michael R., Boyer, David R., Cascio, Duilio, Bali, Manya, Eisenberg, David S.
Publicado 2022

De novo designed protein inhibitors of amyloid aggregation and seeding

por Murray, Kevin A., Hu, Carolyn J., Griner, Sarah L., Pan, Hope, Bowler, Jeannette T., Abskharon, Romany, Rosenberg, Gregory M., Cheng, Xinyi, Seidler, Paul M., Eisenberg, David S.
Publicado 2022

Structure-based inhibitors of amyloid beta core suggest a common interface with tau

por Griner, Sarah L, Seidler, Paul, Bowler, Jeannette, Murray, Kevin A, Yang, Tianxiao Peter, Sahay, Shruti, Sawaya, Michael R, Cascio, Duilio, Rodriguez, Jose A, Philipp, Stephan, Sosna, Justyna, Glabe, Charles G, Gonen, Tamir, Eisenberg, David S
Publicado 2019

Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils

por Murray, Kevin A., Hu, Carolyn J., Pan, Hope, Lu, Jiahui, Abskharon, Romany, Bowler, Jeannette T., Rosenberg, Gregory M., Williams, Christopher K., Elezi, Gazmend, Balbirnie, Melinda, Faull, Kym F., Vinters, Harry V., Seidler, Paul M., Eisenberg, David S.
Publicado 2023

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

por Tayeb-Fligelman, Einav, Bowler, Jeannette T., Tai, Christen E., Sawaya, Michael R., Jiang, Yi Xiao, Garcia, Gustavo, Griner, Sarah L., Cheng, Xinyi, Salwinski, Lukasz, Lutter, Liisa, Seidler, Paul M., Lu, Jiahui, Rosenberg, Gregory M., Hou, Ke, Abskharon, Romany, Pan, Hope, Zee, Chih-Te, Boyer, David R., Li, Yan, Anderson, Daniel H., Murray, Kevin A., Falcon, Genesis, Cascio, Duilio, Saelices, Lorena, Damoiseaux, Robert, Arumugaswami, Vaithilingaraja, Guo, Feng, Eisenberg, David S.
Publicado 2023