The role of cGMP signalling in regulating life cycle progression of Plasmodium

por Hopp, Christine S., Bowyer, Paul W., Baker, David A.
Publicado 2012

Global Profiling of Proteolysis during Rupture of Plasmodium falciparum from the Host Erythrocyte

por Bowyer, Paul W., Simon, Gabriel M., Cravatt, Benjamin F., Bogyo, Matthew
Publicado 2011

Proteomic Analysis of Fractionated Toxoplasma Oocysts Reveals Clues to Their Environmental Resistance

por Fritz, Heather M., Bowyer, Paul W., Bogyo, Matthew, Conrad, Patricia A., Boothroyd, John C.
Publicado 2012

The establishment of a WHO Reference Reagent for anti-malaria (Plasmodium falciparum) human serum

por Bryan, Donna, Silva, Nilupa, Rigsby, Peter, Dougall, Thomas, Corran, Patrick, Bowyer, Paul W., Ho, Mei Mei
Publicado 2017

Small-molecule inhibition of a depalmitoylase enhances Toxoplasma host-cell invasion

por Child, Matthew A., Hall, Carolyn I., Beck, Josh R., Ofori, Leslie O., Albrow, Victoria E., Garland, Megan, Bowyer, Paul W., Bradley, Peter J., Powers, James C., Boothroyd, John C., Weerapana, Eranthie, Bogyo, Matthew
Publicado 2013

Optimization of incubation conditions of Plasmodium falciparum antibody multiplex assays to measure IgG, IgG(1–4), IgM and IgE using standard and customized reference pools for ser...

por Ubillos, Itziar, Jiménez, Alfons, Vidal, Marta, Bowyer, Paul W., Gaur, Deepak, Dutta, Sheetij, Gamain, Benoit, Coppel, Ross, Chauhan, Virander, Lanar, David, Chitnis, Chetan, Angov, Evelina, Beeson, James, Cavanagh, David, Campo, Joseph J., Aguilar, Ruth, Dobaño, Carlota
Publicado 2018

Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies

por Nacer, Adéla, Kivi, Gaily, Pert, Raini, Juronen, Erkki, Holenya, Pavlo, Aliprandini, Eduardo, Amino, Rogerio, Silvie, Olivier, Quinkert, Doris, Le Duff, Yann, Hurley, Matthew, Reimer, Ulf, Tover, Andres, Draper, Simon J., Gilbert, Sarah, Ho, Mei Mei, Bowyer, Paul W.
Publicado 2022

Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty

por Large, Jonathan M., Birchall, Kristian, Bouloc, Nathalie S., Merritt, Andy T., Smiljanic-Hurley, Ela, Tsagris, Denise J., Wheldon, Mary C., Ansell, Keith H., Coombs, Peter J., Kettleborough, Catherine A., Whalley, David, Stewart, Lindsay B., Bowyer, Paul W., Baker, David A., Osborne, Simon A.
Publicado 2019

Heterotypic interactions drive antibody synergy against a malaria vaccine candidate

por Ragotte, Robert J., Pulido, David, Lias, Amelia M., Quinkert, Doris, Alanine, Daniel G. W., Jamwal, Abhishek, Davies, Hannah, Nacer, Adéla, Lowe, Edward D., Grime, Geoffrey W., Illingworth, Joseph J., Donat, Robert F., Garman, Elspeth F., Bowyer, Paul W., Higgins, Matthew K., Draper, Simon J.
Publicado 2022

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Paras...

por Green, Judith L., Moon, Robert W., Whalley, David, Bowyer, Paul W., Wallace, Claire, Rochani, Ankit, Nageshan, Rishi K., Howell, Steven A., Grainger, Munira, Jones, Hayley M., Ansell, Keith H., Chapman, Timothy M., Taylor, Debra L., Osborne, Simon A., Baker, David A., Tatu, Utpal, Holder, Anthony A.
Publicado 2016

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection

por Aguirre-Botero, Manuela C., Wang, Lawrence T., Formaglio, Pauline, Aliprandini, Eduardo, Thiberge, Jean-Michel, Schön, Arne, Flores-Garcia, Yevel, Mathis-Torres, Shamika, Flynn, Barbara J., da Silva Pereira, Lais, Le Duff, Yann, Hurley, Mathew, Nacer, Adéla, Bowyer, Paul W., Zavala, Fidel, Idris, Azza H., Francica, Joseph R., Seder, Robert A., Amino, Rogerio
Publicado 2023

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

por Baker, David A., Stewart, Lindsay B., Large, Jonathan M., Bowyer, Paul W., Ansell, Keith H., Jiménez-Díaz, María B., El Bakkouri, Majida, Birchall, Kristian, Dechering, Koen J., Bouloc, Nathalie S., Coombs, Peter J., Whalley, David, Harding, Denise J., Smiljanic-Hurley, Ela, Wheldon, Mary C., Walker, Eloise M., Dessens, Johannes T., Lafuente, María José, Sanz, Laura M., Gamo, Francisco-Javier, Ferrer, Santiago B., Hui, Raymond, Bousema, Teun, Angulo-Barturén, Iñigo, Merritt, Andy T., Croft, Simon L., Gutteridge, Winston E., Kettleborough, Catherine A., Osborne, Simon A.
Publicado 2017