Value of combining dynamic contrast enhanced ultrasound and optoacoustic tomography for hypoxia imaging

por Shah, Anant, Bush, Nigel, Box, Gary, Eccles, Suzanne, Bamber, Jeffrey
Publicado 2017

Evaluation of the Response of Intracranial Xenografts to VEGF Signaling Inhibition Using Multiparametric MRI

por Boult, Jessica K.R., Box, Gary, Vinci, Maria, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, Robinson, Simon P.
Publicado 2017

Therapeutic Dose Response of Acoustic Cluster Therapy in Combination With Irinotecan for the Treatment of Human Colon Cancer in Mice

por Bush, Nigel, Healey, Andrew, Shah, Anant, Box, Gary, Kirkin, Vladimir, Kotopoulis, Spiros, Kvåle, Svein, Sontum, Per Christian, Bamber, Jeffrey
Publicado 2019

Identification of ovarian high-grade serous carcinoma cell lines that show estrogen-sensitive growth as xenografts in immunocompromised mice

por De Haven Brandon, Alexis, Box, Gary, Hallsworth, Albert, Court, William, Matthews, Nicoll, Herodek, Balint, Arteagabeitia, Aitor Bermejo, Valenti, Melanie, Kirkin, Vladimir
Publicado 2020

Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd‐DTPA and USPIO‐enhanced imaging

por Boult, Jessica K.R., Borri, Marco, Jury, Alexa, Popov, Sergey, Box, Gary, Perryman, Lara, Eccles, Suzanne A., Jones, Chris, Robinson, Simon P.
Publicado 2016

PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion

por Dart, Anna E., Box, Gary M., Court, William, Gale, Madeline E., Brown, John P., Pinder, Sarah E., Eccles, Suzanne A., Wells, Claire M.
Publicado 2015

Breast Tumour Kinase (Brk/PTK6) Contributes to Breast Tumour Xenograft Growth and Modulates Chemotherapeutic Responses In Vitro

por Burmi, Rajpal S., Box, Gary M., Wazir, Umar, Hussain, Haroon A., Davies, Julie A., Court, William J., Eccles, Suzanne A., Jiang, Wen G., Mokbel, Kefah, Harvey, Amanda J.
Publicado 2022

Theranostic Attributes of Acoustic Cluster Therapy and Its Use for Enhancing the Effectiveness of Liposomal Doxorubicin Treatment of Human Triple Negative Breast Cancer in Mice

por Bush, Nigel, Healey, Andrew, Shah, Anant, Box, Gary, Kirkin, Vladimir, Eccles, Sue, Sontum, Per Christian, Kotopoulis, Spiros, Kvåle, Svein, van Wamel, Annemieke, Davies, Catharina de Lange, Bamber, Jeffrey
Publicado 2020

IMG-12. CHARACTERISATION OF MODELS OF H3F3A_G34R/V MUTANT PAEDIATRIC GLIOBLASTOMA IN VIVO USING MAGNETIC RESONANCE IMAGING

por Boult, Jessica, Bjerke, Lynn, Fofana, Mariama, Vinci, Maria, Molinari, Valeria, Mackay, Alan, Temelso, Sara, Box, Gary, Eccles, Suzanne, Carcaboso, Angel, Castro, Maria, Waanders, Angela, Cole, Kristina, Jones, Chris, Robinson, Simon
Publicado 2020

Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma

por Baker, Lauren C. J., Sikka, Arti, Price, Jonathan M., Boult, Jessica K. R., Lepicard, Elise Y., Box, Gary, Jamin, Yann, Spinks, Terry J., Kramer-Marek, Gabriela, Leach, Martin O., Eccles, Suzanne A., Box, Carol, Robinson, Simon P.
Publicado 2018

Optimization of Imidazo[4,5-b]pyridine-Based Kinase Inhibitors: Identification of a Dual FLT3/Aurora Kinase Inhibitor as an Orally Bioavailable Preclinical Development Candidate fo...

por Bavetsias, Vassilios, Crumpler, Simon, Sun, Chongbo, Avery, Sian, Atrash, Butrus, Faisal, Amir, Moore, Andrew S., Kosmopoulou, Magda, Brown, Nathan, Sheldrake, Peter W., Bush, Katherine, Henley, Alan, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Raynaud, Florence I., Workman, Paul, Eccles, Suzanne A., Bayliss, Richard, Linardopoulos, Spiros, Blagg, Julian
Publicado 2012

Discovery of 3-Alkoxyamino-5-(pyridin-2-ylamino)pyrazine-2-carbonitriles as Selective, Orally Bioavailable CHK1 Inhibitors

por Lainchbury, Michael, Matthews, Thomas P., McHardy, Tatiana, Boxall, Kathy J., Walton, Michael I., Eve, Paul D., Hayes, Angela, Valenti, Melanie R., de Haven Brandon, Alexis K., Box, Gary, Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian
Publicado 2012

Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

por Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, Whittaker, Steven R.
Publicado 2018

Correction: Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer

por Wagner, Steve, Vlachogiannis, Georgios, De Haven Brandon, Alexis, Valenti, Melanie, Box, Gary, Jenkins, Liam, Mancusi, Caterina, Self, Annette, Manodoro, Floriana, Assiotis, Ioannis, Robinson, Penny, Chauhan, Ritika, Rust, Alistair G., Matthews, Nik, Eason, Kate, Khan, Khurum, Starling, Naureen, Cunningham, David, Sadanandam, Anguraj, Isacke, Clare M., Kirkin, Vladimir, Valeri, Nicola, Whittaker, Steven R.
Publicado 2019

FGF7–FGFR2 autocrine signaling increases growth and chemoresistance of fusion‐positive rhabdomyosarcomas

por Milton, Christopher I., Selfe, Joanna, Aladowicz, Ewa, Man, Stella Y. K., Bernauer, Carolina, Missiaglia, Edoardo, Walters, Zoë S., Gatz, Susanne A., Kelsey, Anna, Generali, Melanie, Box, Gary, Valenti, Melanie, de Haven‐Brandon, Alexis, Galiwango, David, Hayes, Angela, Clarke, Matthew, Izquierdo, Elisa, Gonzalez De Castro, David, Raynaud, Florence I., Kirkin, Vladimir, Shipley, Janet M.
Publicado 2021

The clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eμ-MYC driven B-cell lymphoma

por Walton, Mike I., Eve, Paul D., Hayes, Angela, Henley, Alan T., Valenti, Melanie R., De Haven Brandon, Alexis K., Box, Gary, Boxall, Kathy J., Tall, Matthew, Swales, Karen, Matthews, Thomas P., McHardy, Tatiana, Lainchbury, Michael, Osborne, James, Hunter, Jill E., Perkins, Neil D., Aherne, G. Wynne, Reader, John C., Raynaud, Florence I., Eccles, Suzanne A., Collins, Ian, Garrett, Michelle D.
Publicado 2015

Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy

por Faisal, Amir, Mak, Grace W Y, Gurden, Mark D, Xavier, Cristina P R, Anderhub, Simon J, Innocenti, Paolo, Westwood, Isaac M, Naud, Sébastien, Hayes, Angela, Box, Gary, Valenti, Melanie R, De Haven Brandon, Alexis K, O'Fee, Lisa, Schmitt, Jessica, Woodward, Hannah L, Burke, Rosemary, vanMontfort, Rob L M, Blagg, Julian, Raynaud, Florence I, Eccles, Suzanne A, Hoelder, Swen, Linardopoulos, Spiros
Publicado 2017

Introduction of a Methyl Group Curbs Metabolism of Pyrido[3,4-d]pyrimidine Monopolar Spindle 1 (MPS1) Inhibitors and Enables the Discovery of the Phase 1 Clinical Candidate N(2)-(2...

por Woodward, Hannah L., Innocenti, Paolo, Cheung, Kwai-Ming J., Hayes, Angela, Roberts, Jennie, Henley, Alan T., Faisal, Amir, Mak, Grace Wing-Yan, Box, Gary, Westwood, Isaac M., Cronin, Nora, Carter, Michael, Valenti, Melanie, De Haven Brandon, Alexis, O’Fee, Lisa, Saville, Harry, Schmitt, Jessica, Burke, Rosemary, Broccatelli, Fabio, van Montfort, Rob L. M., Raynaud, Florence I., Eccles, Suzanne A., Linardopoulos, Spiros, Blagg, Julian, Hoelder, Swen
Publicado 2018

A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease

por Dale, Trevor, Clarke, Paul A., Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A., Wienke, Dirk, Blagg, Julian
Publicado 2015

Structure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold Morphing

por Reader, John C., Matthews, Thomas P., Klair, Suki, Cheung, Kwai-Ming J., Scanlon, Jane, Proisy, Nicolas, Addison, Glynn, Ellard, John, Piton, Nelly, Taylor, Suzanne, Cherry, Michael, Fisher, Martin, Boxall, Kathy, Burns, Samantha, Walton, Michael I., Westwood, Isaac M., Hayes, Angela, Eve, Paul, Valenti, Melanie, de Haven Brandon, Alexis, Box, Gary, van Montfort, Rob L. M., Williams, David H., Aherne, G. Wynne, Raynaud, Florence I., Eccles, Suzanne A., Garrett, Michelle D., Collins, Ian
Publicado 2011