Insights gained from gene therapy in animal models of retGC1 deficiency

por Boye, Shannon E.
Publicado 2014

Identifying and Overcoming Challenges in Developing Effective Treatments for Usher 1B: A Workshop Report

por Boye, Shannon E., Durham, Todd, Laster, Amy, Gelfman, Claire M., Sahel, José-Alain
Publicado 2023

Improving retinal vascular endothelial cell tropism through rational rAAV capsid design

por Periasamy, Ramesh, Patel, Dwani D., Boye, Sanford L., Boye, Shannon E., Lipinski, Daniel M.
Publicado 2023

Quantifying transduction efficiencies of unmodified and tyrosine capsid mutant AAV vectors in vitro using two ocular cell lines

por Ryals, Renee C., Boye, Sanford L., Dinculescu, Astra, Hauswirth, William W., Boye, Shannon E.
Publicado 2011

RNAi-Mediated Gene Suppression in a GCAP1(L151F) Cone-Rod Dystrophy Mouse Model

por Jiang, Li, Li, Tansy Z., Boye, Shannon E., Hauswirth, William W., Frederick, Jeanne M., Baehr, Wolfgang
Publicado 2013

Functional study of two biochemically unusual mutations in GUCY2D Leber congenital amaurosis expressed via adenoassociated virus vector in mouse retinas

por Boye, Sanford L., Olshevskaya, Elena V., Peshenko, Igor V., McCullough, K. Tyler, Boye, Shannon E., Dizhoor, Alexander M.
Publicado 2016

rAAV2/5 gene-targeting to rods: dose-dependent efficiency and complications associated with different promoters

por Beltran, William A., Boye, Sanford L., Boye, Shannon E., Chiodo, Vince A., Lewin, Alfred S., Hauswirth, William W., Aguirre, Gustavo D.
Publicado 2010

Retinal gene therapy with a large MYO7A cDNA using adeno-associated virus

por Lopes, Vanda S., Boye, Shannon E., Louie, Carrie M., Boye, Sanford, Dyka, Frank, Chiodo, Vince, Fofo, Hugo, Hauswirth, William W., Williams, David S.
Publicado 2013

Site-specific modifications to AAV8 capsid yields enhanced brain transduction in the neonatal MPS IIIB mouse

por Gilkes, Janine A., Judkins, Benjamin L., Herrera, Brontie N., Mandel, Ronald J., Boye, Sanford L., Boye, Shannon E., Srivastava, Arun, Heldermon, Coy D.
Publicado 2020

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

por Boye, Shannon E., Boye, Sanford L., Pang, Jijing, Ryals, Renee, Everhart, Drew, Umino, Yumiko, Neeley, Andy W., Besharse, Joseph, Barlow, Robert, Hauswirth, William W.
Publicado 2010

Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat

por Bogner, Barbara, Boye, Sanford L., Min, Seok Hong, Peterson, James J., Ruan, Qing, Zhang, Zhonghong, Reitsamer, Herbert A., Hauswirth, William W., Boye, Shannon E.
Publicado 2015

Targeted Gene Delivery to the Enteric Nervous System Using AAV: A Comparison Across Serotypes and Capsid Mutants

por Benskey, Matthew J, Kuhn, Nathan C, Galligan, James J, Garcia, Joanna, Boye, Shannon E, Hauswirth, William W, Mueller, Christian, Boye, Sanford L, Manfredsson, Fredric P
Publicado 2015

Development of an AAV-CRISPR-Cas9-based treatment for dominant cone-rod dystrophy 6

por Mellen, Russell W., Calabro, Kaitlyn R., McCullough, K. Tyler, Crosson, Sean M., Cova, Alejandro de la, Fajardo, Diego, Xu, Emily, Boye, Sanford L., Boye, Shannon E.
Publicado 2023

Novel Methodology for Creating Macaque Retinas with Sortable Photoreceptors and Ganglion Cells

por Choudhury, Shreyasi, Strang, Christianne E., Alexander, John J., Scalabrino, Miranda L., Lynch Hill, Julie, Kasuga, Daniel T., Witherspoon, C. Douglas, Boye, Sanford L., Gamlin, Paul D., Boye, Shannon E.
Publicado 2016

Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS

por Kanaan, Nicholas M., Sellnow, Rhyomi C., Boye, Sanford L., Coberly, Ben, Bennett, Antonette, Agbandje-McKenna, Mavis, Sortwell, Caryl E., Hauswirth, William W., Boye, Shannon E., Manfredsson, Fredric P.
Publicado 2017

A Novel Mouse Model of MYO7A USH1B Reveals Auditory and Visual System Haploinsufficiencies

por Calabro, Kaitlyn R., Boye, Sanford L., Choudhury, Shreyasi, Fajardo, Diego, Peterson, James J., Li, Wei, Crosson, Sean M., Kim, Mi-Jung, Ding, Dalian, Salvi, Richard, Someya, Shinichi, Boye, Shannon E.
Publicado 2019

SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration

por Sasaki, Yo, Kakita, Hiroki, Kubota, Shunsuke, Sene, Abdoulaye, Lee, Tae Jun, Ban, Norimitsu, Dong, Zhenyu, Lin, Joseph B, Boye, Sanford L, DiAntonio, Aaron, Boye, Shannon E, Apte, Rajendra S, Milbrandt, Jeffrey
Publicado 2020

Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

por Ildefonso, Cristhian J., Jaime, Henrique, Brown, Emily E., Iwata, Ryo L., Ahmed, Chulbul M., Massengill, Michael T., Biswal, Manas R., Boye, Shannon E., Hauswirth, William W., Ash, John D., Li, Qiuhong, Lewin, Alfred S.
Publicado 2016

Preclinical studies in support of phase I/II clinical trials to treat GUCY2D-associated Leber congenital amaurosis

por Boye, Sanford L., O’Riordan, Catherine, Morris, James, Lukason, Michael, Compton, David, Baek, Rena, Elmore, Dana M., Peterson, James.J., Fajardo, Diego, McCullough, K. Tyler, Scaria, Abraham, McVie-Wylie, Alison, Boye, Shannon E.
Publicado 2022

Safety and improved efficacy signals following gene therapy in childhood blindness caused by GUCY2D mutations

por Jacobson, Samuel G., Cideciyan, Artur V., Ho, Allen C., Peshenko, Igor V., Garafalo, Alexandra V., Roman, Alejandro J., Sumaroka, Alexander, Wu, Vivian, Krishnan, Arun K., Sheplock, Rebecca, Boye, Sanford L., Dizhoor, Alexander M., Boye, Shannon E.
Publicado 2021