Cryo-EM Structures of Four Polymorphic TDP-43 Amyloid Cores

por Cao, Qin, Boyer, David R., Sawaya, Michael R., Ge, Peng, Eisenberg, David S.
Publicado 2019

Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils

por Cao, Qin, Boyer, David R., Sawaya, Michael R., Ge, Peng, Eisenberg, David S.
Publicado 2020

Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets

por Bowler, Jeannette T., Sawaya, Michael R., Boyer, David R., Cascio, Duilio, Bali, Manya, Eisenberg, David S.
Publicado 2022

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs

por Boyer, David R., Li, Binsen, Sun, Chuanqi, Fan, Weijia, Sawaya, Michael R., Jiang, Lin, Eisenberg, David S.
Publicado 2019

CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid

por Lu, Jiahui, Cao, Qin, Hughes, Michael P., Sawaya, Michael R., Boyer, David R., Cascio, Duilio, Eisenberg, David S.
Publicado 2020

Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation

por Abskharon, Romany, Sawaya, Michael R., Boyer, David R., Cao, Qin, Nguyen, Binh A., Cascio, Duilio, Eisenberg, David S.
Publicado 2022

Structure of amyloid-β (20-34) with Alzheimer’s-associated isomerization at Asp23 reveals a distinct protofilament interface

por Warmack, Rebeccah A., Boyer, David R., Zee, Chih-Te, Richards, Logan S., Sawaya, Michael R., Cascio, Duilio, Gonen, Tamir, Eisenberg, David S., Clarke, Steven G.
Publicado 2019

Atomic Structures of Segments from TDP-43 LCD and insight into Reversible and Pathogenic Aggregation

por Guenther, Elizabeth L., Cao, Qin, Trinh, Hamilton, Lu, Jiahui, Sawaya, Michael R., Cascio, Duilio, Boyer, David R., Rodriguez, Jose A., Hughes, Michael P., Eisenberg, David S.
Publicado 2018

Nanoscale mosaicity revealed in peptide microcrystals by scanning electron nanodiffraction

por Gallagher-Jones, Marcus, Ophus, Colin, Bustillo, Karen C., Boyer, David R., Panova, Ouliana, Glynn, Calina, Zee, Chih-Te, Ciston, Jim, Mancia, Kevin Canton, Minor, Andrew M., Rodriguez, Jose A.
Publicado 2019

Cryo-EM of full-length α-synuclein reveals fibril polymorphs with a common structural kernel

por Li, Binsen, Ge, Peng, Murray, Kevin A., Sheth, Phorum, Zhang, Meng, Nair, Gayatri, Sawaya, Michael R., Shin, Woo Shik, Boyer, David R., Ye, Shulin, Eisenberg, David S., Zhou, Z. Hong, Jiang, Lin
Publicado 2018

Structure-based discovery of small molecules that disaggregate Alzheimer’s disease tissue derived tau fibrils in vitro

por Seidler, Paul M., Murray, Kevin A., Boyer, David R., Ge, Peng, Sawaya, Michael R., Hu, Carolyn J., Cheng, Xinyi, Abskharon, Romany, Pan, Hope, DeTure, Michael A., Williams, Christopher K., Dickson, Dennis W., Vinters, Harry V., Eisenberg, David S.
Publicado 2022

Sub-ångstrom cryo-EM structure of a prion protofibril reveals a polar clasp

por Gallagher-Jones, Marcus, Glynn, Calina, Boyer, David R., Martynowycz, Michael W., Hernandez, Evelyn, Miao, Jennifer, Zee, Chih-Te, Novikova, Irina V., Goldschmidt, Lukasz, McFarlane, Heather T., Helguera, Gustavo F., Evans, James E., Sawaya, Michael R., Cascio, Duilio, Eisenberg, David, Gonen, Tamir, Rodriguez, Jose A.
Publicado 2018

Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils

por Tayeb-Fligelman, Einav, Bowler, Jeannette T., Tai, Christen E., Sawaya, Michael R., Jiang, Yi Xiao, Garcia, Gustavo, Griner, Sarah L., Cheng, Xinyi, Salwinski, Lukasz, Lutter, Liisa, Seidler, Paul M., Lu, Jiahui, Rosenberg, Gregory M., Hou, Ke, Abskharon, Romany, Pan, Hope, Zee, Chih-Te, Boyer, David R., Li, Yan, Anderson, Daniel H., Murray, Kevin A., Falcon, Genesis, Cascio, Duilio, Saelices, Lorena, Damoiseaux, Robert, Arumugaswami, Vaithilingaraja, Guo, Feng, Eisenberg, David S.
Publicado 2023

Structure-based design of nanobodies that inhibit seeding of Alzheimer’s patient–extracted tau fibrils

por Abskharon, Romany, Pan, Hope, Sawaya, Michael R., Seidler, Paul M., Olivares, Eileen J., Chen, Yu, Murray, Kevin A., Zhang, Jeffrey, Lantz, Carter, Bentzel, Megan, Boyer, David R., Cascio, Duilio, Nguyen, Binh A., Hou, Ke, Cheng, Xinyi, Pardon, Els, Williams, Christopher K., Nana, Alissa L., Vinters, Harry V., Spina, Salvatore, Grinberg, Lea T., Seeley, William W., Steyaert, Jan, Glabe, Charles G., Ogorzalek Loo, Rachel R., Loo, Joseph A., Eisenberg, David S.
Publicado 2023