Reprogramming of the Caseinolytic Protease by ADEP Antibiotics: Molecular Mechanism, Cellular Consequences, Therapeutic Potential

por Brötz-Oesterhelt, Heike, Vorbach, Andreas
Publicado 2021

Generation of Lasso Peptide-Based ClpP Binders

por Malik, Imran T., Hegemann, Julian D., Brötz-Oesterhelt, Heike
Publicado 2021

Massiliamide, a cyclic tetrapeptide with potent tyrosinase inhibitory properties from the Gram-negative bacterium Massilia albidiflava DSM 17472(T)

por Frediansyah, Andri, Straetener, Jan, Brötz-Oesterhelt, Heike, Gross, Harald
Publicado 2020

Polar localization of the ATPase ClpV-5 occurs independent of type VI secretion system apparatus proteins in Burkholderia thailandensis

por Lennings, Jan, Mayer, Christian, Makhlouf, Munira, Brötz-Oesterhelt, Heike, Schwarz, Sandra
Publicado 2019

Acyldepsipeptide Probes Facilitate Specific Detection of Caseinolytic Protease P Independent of Its Oligomeric and Activity State

por Eyermann, Barbara, Meixner, Maximilian, Brötz‐Oesterhelt, Heike, Antes, Iris, Sieber, Stephan A.
Publicado 2020

Draft Genome Sequence of the Extensively Drug-Resistant Pseudomonas aeruginosa Clinical Isolate TUEPA7472

por Miess, Henrike, Jahanshah, Ghazaleh, Brötz-Oesterhelt, Heike, Willmann, Matthias, Peter, Silke, Gross, Harald
Publicado 2018

Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

por Silber, Nadine, Pan, Stefan, Schäkermann, Sina, Mayer, Christian, Brötz-Oesterhelt, Heike, Sass, Peter
Publicado 2020

Synthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites

por Xu, Houchao, Wochele, Anne, Luo, Minghe, Schnakenburg, Gregor, Sun, Yuhui, Brötz-Oesterhelt, Heike, Dickschat, Jeroen S
Publicado 2022

Identification of macrocyclic peptides which activate bacterial cylindrical proteases

por Walther, Raoul, Westermann, Linda M., Carmali, Sheiliza, Jackson, Sophie E., Brötz-Oesterhelt, Heike, Spring, David R.
Publicado 2023

New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A–C, Revealed by Genome Mining of Nocardia terpenica IFM 0406

por Chen, Julia, Frediansyah, Andri, Männle, Daniel, Straetener, Jan, Brötz‐Oesterhelt, Heike, Ziemert, Nadine, Kaysser, Leonard, Gross, Harald
Publicado 2020

Nocathioamides, Uncovered by a Tunable Metabologenomic Approach, Define a Novel Class of Chimeric Lanthipeptides

por Saad, Hamada, Aziz, Saefuddin, Gehringer, Matthias, Kramer, Markus, Straetener, Jan, Berscheid, Anne, Brötz‐Oesterhelt, Heike, Gross, Harald
Publicado 2021

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

por Kirstein, Janine, Hoffmann, Anja, Lilie, Hauke, Schmidt, Ronny, Rübsamen-Waigmann, Helga, Brötz-Oesterhelt, Heike, Mogk, Axel, Turgay, Kürşad
Publicado 2009

Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis

por Reinhardt, Laura, Thomy, Dhana, Lakemeyer, Markus, Westermann, Linda Maria, Ortega, Joaquin, Sieber, Stephan A., Sass, Peter, Brötz-Oesterhelt, Heike
Publicado 2022

The Antibiotic Negamycin Crosses the Bacterial Cytoplasmic Membrane by Multiple Routes

por Hörömpöli, Daniel, Ciglia, Catherine, Glüsenkamp, Karl-Heinz, Haustedt, Lars Ole, Falkenstein-Paul, Hildegard, Bendas, Gerd, Berscheid, Anne, Brötz-Oesterhelt, Heike
Publicado 2021

Molecular Characterization of the ClpC AAA+ ATPase in the Biology of Chlamydia trachomatis

por Pan, Stefan, Jensen, Aaron A., Wood, Nicholas A., Henrichfreise, Beate, Brötz-Oesterhelt, Heike, Fisher, Derek J., Sass, Peter, Ouellette, Scot P.
Publicado 2023

Bioinformatics-Guided Discovery of Biaryl-Tailored Lasso Peptides

por Saad, Hamada, Majer, Thomas, Bhattarai, Keshab, Lampe, Sarah, Nguyen, Dinh T., Kramer, Markus, Straetener, Jan, Brötz-Oesterhelt, Heike, Mitchell, Douglas A., Gross, Harald
Publicado 2023

Bioinformatics-guided discovery of biaryl-linked lasso peptides

por Saad, Hamada, Majer, Thomas, Bhattarai, Keshab, Lampe, Sarah, Nguyen, Dinh T., Kramer, Markus, Straetener, Jan, Brötz-Oesterhelt, Heike, Mitchell, Douglas A., Gross, Harald
Publicado 2023

Ψ-Footprinting approach for the identification of protein synthesis inhibitor producers

por Handel, Franziska, Kulik, Andreas, Wex, Katharina W, Berscheid, Anne, Saur, Julian S, Winkler, Anika, Wibberg, Daniel, Kalinowski, Jörn, Brötz-Oesterhelt, Heike, Mast, Yvonne
Publicado 2022

Ubiquitously expressed Human Beta Defensin 1 (hBD1) forms bacteria-entrapping nets in a redox dependent mode of action

por Raschig, Judith, Mailänder-Sánchez, Daniela, Berscheid, Anne, Berger, Jürgen, Strömstedt, Adam A., Courth, Lioba F., Malek, Nisar P., Brötz-Oesterhelt, Heike, Wehkamp, Jan
Publicado 2017

Functional Characterisation of ClpP Mutations Conferring Resistance to Acyldepsipeptide Antibiotics in Firmicutes

por Malik, Imran T., Pereira, Rebeca, Vielberg, Marie‐Theres, Mayer, Christian, Straetener, Jan, Thomy, Dhana, Famulla, Kirsten, Castro, Helena, Sass, Peter, Groll, Michael, Brötz‐Oesterhelt, Heike
Publicado 2020