The future of host cell protein (HCP) identification during process development and manufacturing linked to a risk‐based management for their control

por Bracewell, Daniel G., Francis, Richard, Smales, C. Mark
Publicado 2015

Effects of lysosomal biotherapeutic recombinant protein expression on cell stress and protease and general host cell protein release in Chinese hamster ovary cells

por Migani, Damiano, Smales, C. Mark, Bracewell, Daniel G.
Publicado 2017

Enriching leukapheresis improves T cell activation and transduction efficiency during CAR T processing

por Noaks, Elsa, Peticone, Carlotta, Kotsopoulou, Ekaterini, Bracewell, Daniel G.
Publicado 2021

A Biological OR(XNOR) Logic Gate Couples Carbon Source and Transgene Expression Switching in a Komagataella phaffii (Pichia pastoris) Strain Co-producing Process-Enhancing Lipase a...

por Bandyopadhyay, Sushobhan, Pavlika, Vasos, Bracewell, Daniel G., Nesbeth, Darren N.
Publicado 2023

Scale-down characterization of post-centrifuge flocculation processes for high-throughput process development

por Espuny Garcia del Real, Georgina, Davies, Jim, Bracewell, Daniel G
Publicado 2014

Fabricating electrospun cellulose nanofibre adsorbents for ion-exchange chromatography

por Dods, Stewart R., Hardick, Oliver, Stevens, Bob, Bracewell, Daniel G.
Publicado 2015

Analysis of fouling and breakthrough of process related impurities during depth filtration using confocal microscopy

por Parau, Maria, Johnson, Thomas F., Pullen, James, Bracewell, Daniel G.
Publicado 2022

Understanding the Relationship Between Biotherapeutic Protein Stability and Solid–Liquid Interfacial Shear in Constant Region Mutants of IgG1 and IgG4

por Tavakoli-Keshe, Roumteen, Phillips, Jonathan J, Turner, Richard, Bracewell, Daniel G
Publicado 2014

Fluorescence based real time monitoring of fouling in process chromatography

por Pathak, Mili, Lintern, Katherine, Chopda, Viki, Bracewell, Daniel G., Rathore, Anurag S.
Publicado 2017

Lentiviral Vector Purification Using Nanofiber Ion-Exchange Chromatography

por Ruscic, Jelena, Perry, Christopher, Mukhopadhyay, Tarit, Takeuchi, Yasu, Bracewell, Daniel G.
Publicado 2019

Synthesis and Assembly of Hepatitis B Virus-Like Particles in a Pichia pastoris Cell-Free System

por Spice, Alex J., Aw, Rochelle, Bracewell, Daniel G., Polizzi, Karen M.
Publicado 2020

Improving the reaction mix of a Pichia pastoris cell-free system using a design of experiments approach to minimise experimental effort

por Spice, Alex J., Aw, Rochelle, Bracewell, Daniel G., Polizzi, Karen M.
Publicado 2020

Escherichia coli-Based Cell-Free Protein Synthesis for Iterative Design of Tandem-Core Virus-Like Particles

por Colant, Noelle, Melinek, Beatrice, Frank, Stefanie, Rosenberg, William, Bracewell, Daniel G.
Publicado 2021

Fouling of an anion exchange chromatography operation in a monoclonal antibody process: Visualization and kinetic studies

por Close, Edward J, Salm, Jeffrey R, Iskra, Timothy, Sørensen, Eva, Bracewell, Daniel G
Publicado 2013

Protein A chromatography increases monoclonal antibody aggregation rate during subsequent low pH virus inactivation hold

por Mazzer, Alice R., Perraud, Xavier, Halley, Jennifer, O’Hara, John, Bracewell, Daniel G.
Publicado 2015

Evaluation of fluorescent dyes to measure protein aggregation within mammalian cell culture supernatants

por Oshinbolu, Sheun, Shah, Rachana, Finka, Gary, Molloy, Mike, Uden, Mark, Bracewell, Daniel G
Publicado 2018

The effect of feed quality due to clarification strategy on the design and performance of protein A periodic counter‐current chromatography

por El‐Sabbahy, Hani, Ward, David, Ogonah, Olotu, Deakin, Lynne, Jellum, Gregory M., Bracewell, Daniel G.
Publicado 2018

Evaluating 3D-printed bioseparation structures using multi-length scale tomography

por Johnson, Thomas F., Conti, Mariachiara, Iacoviello, Francesco, Shearing, Paul R., Pullen, James, Dimartino, Simone, Bracewell, Daniel G.
Publicado 2023

Differential Response in Downstream Processing of CHO Cells Grown Under Mild Hypothermic Conditions

por Tait, Andrew S, Tarrant, Richard D R, Velez-Suberbie, M Lourdes, Spencer, Daniel I R, Bracewell, Daniel G
Publicado 2013

Neutron reflectivity measurement of protein A–antibody complex at the solid-liquid interface

por Mazzer, Alice R., Clifton, Luke A., Perevozchikova, Tatiana, Butler, Paul D., Roberts, Christopher J., Bracewell, Daniel G.
Publicado 2017