Employing novel animal models in the design of clinically efficacious GPCR ligands()

por Bradley, Sophie J, Riaz, Sajjad A, Tobin, Andrew B
Publicado 2014

Targeting the Type 5 Metabotropic Glutamate Receptor: A Potential Therapeutic Strategy for Neurodegenerative Diseases?

por Budgett, Rebecca F., Bakker, Geor, Sergeev, Eugenia, Bennett, Kirstie A., Bradley, Sophie J.
Publicado 2022

Inhibition of neuroinflammatory nitric oxide signaling suppresses glycation and prevents neuronal dysfunction in mouse prion disease

por Bourgognon, Julie-Myrtille, Spiers, Jereme G., Robinson, Sue W., Scheiblich, Hannah, Glynn, Paul, Ortori, Catharine, Bradley, Sophie J., Tobin, Andrew B., Steinert, Joern R.
Publicado 2021

Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias

por van der Westhuizen, Emma T., Choy, K. H. Christopher, Valant, Celine, McKenzie-Nickson, Simon, Bradley, Sophie J., Tobin, Andrew B., Sexton, Patrick M., Christopoulos, Arthur
Publicado 2021

The M(1) muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes

por Marsango, Sara, Jenkins, Laura, Pediani, John D., Bradley, Sophie J., Ward, Richard J., Hesse, Sarah, Biener, Gabriel, Stoneman, Michael R., Tobin, Andrew B., Raicu, Valerica, Milligan, Graeme
Publicado 2022

Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease

por Scarpa, Miriam, Molloy, Colin, Jenkins, Laura, Strellis, Bethany, Budgett, Rebecca F., Hesse, Sarah, Dwomoh, Louis, Marsango, Sara, Tejeda, Gonzalo S., Rossi, Mario, Ahmed, Zeshan, Milligan, Graeme, Hudson, Brian D., Tobin, Andrew B., Bradley, Sophie J.
Publicado 2021

An Antibody Biosensor Establishes the Activation of the M(1) Muscarinic Acetylcholine Receptor during Learning and Memory

por Butcher, Adrian J., Bradley, Sophie J., Prihandoko, Rudi, Brooke, Simon M., Mogg, Adrian, Bourgognon, Julie-Myrtille, Macedo-Hatch, Timothy, Edwards, Jennifer M., Bottrill, Andrew R., Challiss, R. A. John, Broad, Lisa M., Felder, Christian C., Tobin, Andrew B.
Publicado 2016

Bitopic Binding Mode of an M(1) Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes

por Bradley, Sophie J., Molloy, Colin, Bundgaard, Christoffer, Mogg, Adrian J., Thompson, Karen J., Dwomoh, Louis, Sanger, Helen E., Crabtree, Michael D., Brooke, Simon M., Sexton, Patrick M., Felder, Christian C., Christopoulos, Arthur, Broad, Lisa M., Tobin, Andrew B., Langmead, Christopher J.
Publicado 2018

M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss

por Bradley, Sophie J., Bourgognon, Julie-Myrtille, Sanger, Helen E., Verity, Nicholas, Mogg, Adrian J., White, David J., Butcher, Adrian J., Moreno, Julie A., Molloy, Colin, Macedo-Hatch, Timothy, Edwards, Jennifer M., Wess, Jurgen, Pawlak, Robert, Read, David J., Sexton, Patrick M., Broad, Lisa M., Steinert, Joern R., Mallucci, Giovanna R., Christopoulos, Arthur, Felder, Christian C., Tobin, Andrew B.
Publicado 2016

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

por Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.
Publicado 2018

Clustered Coding Variants in the Glutamate Receptor Complexes of Individuals with Schizophrenia and Bipolar Disorder

por Frank, René A. W., McRae, Allan F., Pocklington, Andrew J., van de Lagemaat, Louie N., Navarro, Pau, Croning, Mike D. R., Komiyama, Noboru H., Bradley, Sophie J., Challiss, R. A. John, Armstrong, J. Douglas, Finn, Robert D., Malloy, Mary P., MacLean, Alan W., Harris, Sarah E., Starr, John M., Bhaskar, Sanjeev S., Howard, Eleanor K., Hunt, Sarah E., Coffey, Alison J., Ranganath, Venkatesh, Deloukas, Panos, Rogers, Jane, Muir, Walter J., Deary, Ian J., Blackwood, Douglas H., Visscher, Peter M., Grant, Seth G. N.
Publicado 2011