From transcriptional regulation to drugging the cancer epigenome

por Bradner, James E
Publicado 2014

BET and BRAF inhibitors act synergistically against BRAF‐mutant melanoma

por Paoluzzi, Luca, Hanniford, Douglas, Sokolova, Elena, Osman, Iman, Darvishian, Farbod, Wang, Jinhua, Bradner, James E., Hernando, Eva
Publicado 2016

Chemical Phylogenetics of Histone Deacetylases

por Bradner, James E., West, Nathan, Grachan, Melissa L., Greenberg, Edward F., Haggarty, Stephen J., Warnow, Tandy, Mazitschek, Ralph
Publicado 2010

HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer

por Hideshima, Teru, Mazitschek, Ralph, Qi, Jun, Mimura, Naoya, Tseng, Jen-Chieh, Kung, Andrew L., Bradner, James E., Anderson, Kenneth C.
Publicado 2017

Correction: HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer

por Hideshima, Teru, Mazitschek, Ralph, Qi, Jun, Mimura, Naoya, Tseng, Jen-Chieh, Kung, Andrew L., Bradner, James E., Anderson, Kenneth C.
Publicado 2021

Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6

por Hu, Yu-Jie, Belaghzal, Houda, Hsiao, Wen-Yu, Qi, Jun, Bradner, James E., Guertin, David A., Sif, Saïd, Imbalzano, Anthony N.
Publicado 2015

Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

por Fowler, Trent, Ghatak, Payel, Price, David H., Conaway, Ronald, Conaway, Joan, Chiang, Cheng-Ming, Bradner, James E., Shilatifard, Ali, Roy, Ananda L.
Publicado 2014

Correction: Regulation of MYC Expression and Differential JQ1 Sensitivity in Cancer Cells

por Fowler, Trent, Ghatak, Payel, Price, David H., Conaway, Ronald, Conaway, Joan, Chiang, Cheng-Ming, Bradner, James E., Shilatifard, Ali, Roy, Ananda L.
Publicado 2015

HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist

por Devaraj, Santhana G. T., Fiskus, Warren, Shah, Bhavin, Qi, Jun, Sun, Baohua, Iyer, Swaminathan P, Sharma, Sunil, Bradner, James E., Bhalla, Kapil N.
Publicado 2015

Models of human core transcriptional regulatory circuitries

por Saint-André, Violaine, Federation, Alexander J., Lin, Charles Y., Abraham, Brian J., Reddy, Jessica, Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Publicado 2016

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition

por Chen, Chong, Liu, Yu, Lu, Chao, Cross, Justin R., Morris, John P., Shroff, Aditya S., Ward, Patrick S., Bradner, James E., Thompson, Craig, Lowe, Scott W.
Publicado 2013

Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies

por Chan, Siu Chiu, Selth, Luke A., Li, Yingming, Nyquist, Michael D., Miao, Lu, Bradner, James E., Raj, Ganesh V., Tilley, Wayne D., Dehm, Scott M.
Publicado 2015

Targeting the epigenetic readers in Ewing Sarcoma inhibits the oncogenic transcription factor EWS/Fli1

por Jacques, Camille, Lamoureux, François, Baud’huin, Marc, Calleja, Lidia Rodriguez, Quillard, Thibaut, Amiaud, Jérôme, Tirode, Franck, Rédini, Françoise, Bradner, James E., Heymann, Dominique, Ory, Benjamin
Publicado 2016

Design and Characterization of Bivalent BET Inhibitors

por Tanaka, Minoru, Roberts, Justin M., Seo, Hyuk-Soo, Souza, Amanda, Paulk, Joshiawa, Scott, Thomas G., DeAngelo, Stephen L., Dhe-Paganon, Sirano, Bradner, James E.
Publicado 2016

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma

por Bolin, Sara, Borgenvik, Anna, Persson, Camilla U., Sundström, Anders, Qi, Jun, Bradner, James E., Weiss, William A., Cho, Yoon-Jae, Weishaupt, Holger, Swartling, Fredrik J.
Publicado 2018

Synthesis and Biological Evaluation of JAHAs: Ferrocene-Based Histone Deacetylase Inhibitors

por Spencer, John, Amin, Jahangir, Wang, Minghua, Packham, Graham, Alwi, Sharifah S. Syed, Tizzard, Graham J., Coles, Simon J., Paranal, Ronald M., Bradner, James E., Heightman, Tom D.
Publicado 2011

Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation

por Gaub, Aline, Sheikh, Bilal N., Basilicata, M. Felicia, Vincent, Marie, Nizon, Mathilde, Colson, Cindy, Bird, Matthew J., Bradner, James E., Thevenon, Julien, Boutros, Michael, Akhtar, Asifa
Publicado 2020

ATAD2 is an epigenetic reader of newly synthesized histone marks during DNA replication

por Koo, Seong Joo, Fernández-Montalván, Amaury E., Badock, Volker, Ott, Christopher J., Holton, Simon J., von Ahsen, Oliver, Toedling, Joern, Vittori, Sarah, Bradner, James E., Gorjánácz, Mátyás
Publicado 2016

JAK2 is dispensable for maintenance of JAK2 mutant B-cell acute lymphoblastic leukemias

por Kim, Sang-Kyu, Knight, Deborah A., Jones, Lisa R., Vervoort, Stephin, Ng, Ashley P., Seymour, John F., Bradner, James E., Waibel, Michaela, Kats, Lev, Johnstone, Ricky W.
Publicado 2018

Bromodomain inhibition shows antitumoral activity in mice and human luminal breast cancer

por Pérez-Salvia, Montserrat, Simó-Riudalbas, Laia, Llinàs-Arias, Pere, Roa, Laura, Setien, Fernando, Soler, Marta, de Moura, Manuel Castro, Bradner, James E., Gonzalez-Suarez, Eva, Moutinho, Catia, Esteller, Manel
Publicado 2017