Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health

por Birkisdóttir, María Björk, Van’t Sant, Lisanne J., Brandt, Renata M. C., Barnhoorn, Sander, Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Jaarsma, Dick
Publicado 2023

Compromised DNA Repair Promotes the Accumulation of Regulatory T Cells With an Aging-Related Phenotype and Responsiveness

por Pieren, Daan K. J., Smits, Noortje A. M., Imholz, Sandra, Nagarajah, Bhawani, van Oostrom, Conny T., Brandt, Renata M. C., Vermeij, Wilbert P., Dollé, Martijn E. T., Guichelaar, Teun
Publicado 2021

Genome-wide RNA polymerase stalling shapes the transcriptome during aging

por Gyenis, Akos, Chang, Jiang, Demmers, Joris J. P. G., Bruens, Serena T., Barnhoorn, Sander, Brandt, Renata M. C., Baar, Marjolein P., Raseta, Marko, Derks, Kasper W. J., Hoeijmakers, Jan H. J., Pothof, Joris
Publicado 2023

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1(−/Δ7) mice

por van der Lugt, Benthe, van Beek, Adriaan A., Aalvink, Steven, Meijer, Ben, Sovran, Bruno, Vermeij, Wilbert P., Brandt, Renata M. C., de Vos, Willem M., Savelkoul, Huub F. J., Steegenga, Wilma T., Belzer, Clara
Publicado 2019

Different responses to DNA damage determine ageing differences between organs

por Vougioukalaki, Maria, Demmers, Joris, Vermeij, Wilbert P., Baar, Marjolein, Bruens, Serena, Magaraki, Aristea, Kuijk, Ewart, Jager, Myrthe, Merzouk, Sarra, Brandt, Renata M.C., Kouwenberg, Janneke, van Boxtel, Ruben, Cuppen, Edwin, Pothof, Joris, Hoeijmakers, Jan H. J.
Publicado 2022

Bone fragility and decline in stem cells in prematurely aging DNA repair deficient trichothiodystrophy mice

por Diderich, Karin E. M., Nicolaije, Claudia, Priemel, Matthias, Waarsing, Jan H., Day, Judd S., Brandt, Renata M. C., Schilling, Arndt F., Botter, Sander M., Weinans, Harrie, van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., van Leeuwen, Johannes P. T. M.
Publicado 2011

Age-Related Skeletal Dynamics and Decrease in Bone Strength in DNA Repair Deficient Male Trichothiodystrophy Mice

por Nicolaije, Claudia, Diderich, Karin E. M., Botter, S. M., Priemel, Matthias, Waarsing, Jan H., Day, Judd S., Brandt, Renata M. C., Schilling, Arndt F., Weinans, Harrie, Van der Eerden, Bram C., van der Horst, Gijsbertus T. J., Hoeijmakers, Jan H. J., van Leeuwen, Johannes P. T. M.
Publicado 2012

The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside

por Birkisdóttir, María B., van Galen, Ivar, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T., Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G., Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H. J., Dollé, Martijn E. T., Vermeij, Wilbert P.
Publicado 2022

Corrigendum: The use of progeroid DNA repair-deficient mice for assessing anti-aging compounds, illustrating the benefits of nicotinamide riboside

por Birkisdóttir, María B., van Galen, Ivar, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, van Dijk, Claire, Nagarajah, Bhawani, Imholz, Sandra, van Oostrom, Conny T., Reiling, Erwin, Gyenis, Ákos, Mastroberardino, Pier G., Jaarsma, Dick, van Steeg, Harry, Hoeijmakers, Jan H. J., Dollé, Martijn E. T., Vermeij, Wilbert P.
Publicado 2022

Soluble guanylate cyclase activator BAY 54–6544 improves vasomotor function and survival in an accelerated ageing mouse model

por Ataei Ataabadi, Ehsan, Golshiri, Keivan, Jüttner, Annika A., de Vries, René, Van den Berg‐Garrelds, Ingrid, Nagtzaam, Nicole M. A., Khan, Hina N., Leijten, Frank P. J., Brandt, Renata M. C., Dik, Willem A., van der Pluijm, Ingrid, Danser, A. H. Jan, Sandner, Peter, Roks, Anton J. M.
Publicado 2022

Cell-Autonomous Progeroid Changes in Conditional Mouse Models for Repair Endonuclease XPG Deficiency

por Barnhoorn, Sander, Uittenboogaard, Lieneke M., Jaarsma, Dick, Vermeij, Wilbert P., Tresini, Maria, Weymaere, Michael, Menoni, Hervé, Brandt, Renata M. C., de Waard, Monique C., Botter, Sander M., Sarker, Altaf H., Jaspers, Nicolaas G. J., van der Horst, Gijsbertus T. J., Cooper, Priscilla K., Hoeijmakers, Jan H. J., van der Pluijm, Ingrid
Publicado 2014

Compression of morbidity in a progeroid mouse model through the attenuation of myostatin/activin signalling

por Alyodawi, Khalid, Vermeij, Wilbert P., Omairi, Saleh, Kretz, Oliver, Hopkinson, Mark, Solagna, Francesca, Joch, Barbara, Brandt, Renata M.C., Barnhoorn, Sander, van Vliet, Nicole, Ridwan, Yanto, Essers, Jeroen, Mitchell, Robert, Morash, Taryn, Pasternack, Arja, Ritvos, Olli, Matsakas, Antonios, Collins‐Hooper, Henry, Huber, Tobias B., Hoeijmakers, Jan H.J., Patel, Ketan
Publicado 2019

Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair‐deficient mice

por Birkisdóttir, María B., Jaarsma, Dick, Brandt, Renata M. C., Barnhoorn, Sander, van Vliet, Nicole, Imholz, Sandra, van Oostrom, Conny T., Nagarajah, Bhawani, Portilla Fernández, Eliana, Roks, Anton J. M., Elgersma, Ype, van Steeg, Harry, Ferreira, José A., Pennings, Jeroen L. A., Hoeijmakers, Jan H. J., Vermeij, Wilbert P., Dollé, Martijn E. T.
Publicado 2021

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

por Milanese, Chiara, Bombardieri, Cíntia R., Sepe, Sara, Barnhoorn, Sander, Payán-Goméz, César, Caruso, Donatella, Audano, Matteo, Pedretti, Silvia, Vermeij, Wilbert P., Brandt, Renata M. C., Gyenis, Akos, Wamelink, Mirjam M., de Wit, Annelieke S., Janssens, Roel C., Leen, René, van Kuilenburg, André B. P., Mitro, Nico, Hoeijmakers, Jan H. J., Mastroberardino, Pier G.
Publicado 2019

Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

por van der Pluijm, Ingrid, Garinis, George A, Brandt, Renata M. C, Gorgels, Theo G. M. F, Wijnhoven, Susan W, Diderich, Karin E. M, de Wit, Jan, Mitchell, James R, van Oostrom, Conny, Beems, Rudolf, Niedernhofer, Laura J, Velasco, Susana, Friedberg, Errol C, Tanaka, Kiyoji, van Steeg, Harry, Hoeijmakers, Jan H. J, van der Horst, Gijsbertus T. J
Publicado 2007

Correction: Impaired Genome Maintenance Suppresses the Growth Hormone–Insulin-Like Growth Factor 1 Axis in Mice with Cockayne Syndrome

por van der Pluijm, Ingrid, Garinis, George A, Brandt, Renata M. C, Gorgels, Theo G. M. F, Wijnhoven, Susan W, Diderich, Karin E. M, de Wit, Jan, Mitchell, James R, van Oostrom, Conny, Beems, Rudolf, Niedernhofer, Laura J, Velasco, Susana, Friedberg, Errol C, Tanaka, Kiyoji, van Steeg, Harry, Hoeijmakers, Jan H. J, van der Horst, Gijsbertus T. J
Publicado 2008

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice

por de Boer, Martine, te Lintel Hekkert, Maaike, Chang, Jiang, van Thiel, Bibi S., Martens, Leonie, Bos, Maxime M., de Kleijnen, Marion G. J., Ridwan, Yanto, Octavia, Yanti, van Deel, Elza D., Blonden, Lau A., Brandt, Renata M. C., Barnhoorn, Sander, Bautista‐Niño, Paula K., Krabbendam‐Peters, Ilona, Wolswinkel, Rianne, Arshi, Banafsheh, Ghanbari, Mohsen, Kupatt, Christian, de Windt, Leon J., Danser, A. H. Jan, van der Pluijm, Ingrid, Remme, Carol Ann, Stoll, Monika, Pothof, Joris, Roks, Anton J. M., Kavousi, Maryam, Essers, Jeroen, van der Velden, Jolanda, Hoeijmakers, Jan H. J., Duncker, Dirk J.
Publicado 2023