Drug discovery in leishmaniasis using protein lipidation as a target

por Brannigan, James A., Wilkinson, Anthony J.
Publicado 2021

Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites

por Olaleye, Tayo O., Brannigan, James A., Roberts, Shirley M., Leatherbarrow, Robin J., Wilkinson, Anthony J., Tate, Edward W.
Publicado 2014

The crystal structure of superoxide dismutase from Plasmodium falciparum

por Boucher, Ian W, Brzozowski, Andrzej M, Brannigan, James A, Schnick, Claudia, Smith, Derek J, Kyes, Sue A, Wilkinson, Anthony J
Publicado 2006

Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase

por Goncalves, Victor, Brannigan, James A., Laporte, Alice, Bell, Andrew S., Roberts, Shirley M., Wilkinson, Anthony J., Leatherbarrow, Robin J., Tate, Edward W.
Publicado 2016

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

por Rackham, Mark D., Brannigan, James A., Rangachari, Kaveri, Meister, Stephan, Wilkinson, Anthony J., Holder, Anthony A., Leatherbarrow, Robin J., Tate, Edward W.
Publicado 2014

Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase

por Yu, Zhiyong, Brannigan, James A., Rangachari, Kaveri, Heal, William P., Wilkinson, Anthony J., Holder, Anthony A., Leatherbarrow, Robin J., Tate, Edward W.
Publicado 2015

The crystal structures of macrophage migration inhibitory factor from Plasmodium falciparum and Plasmodium berghei

por Dobson, Sarah E, Augustijn, Kevin D, Brannigan, James A, Schnick, Claudia, Janse, Chris J, Dodson, Eleanor J, Waters, Andrew P, Wilkinson, Anthony J
Publicado 2009

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase

por Rackham, Mark D., Brannigan, James A., Moss, David K., Yu, Zhiyong, Wilkinson, Anthony J., Holder, Anthony A., Tate, Edward W., Leatherbarrow, Robin J.
Publicado 2012

Structure and non-essential function of glycerol kinase in Plasmodium falciparum blood stages

por Schnick, Claudia, Polley, Spencer D, Fivelman, Quinton L, Ranford-Cartwright, Lisa C, Wilkinson, Shane R, Brannigan, James A, Wilkinson, Anthony J, Baker, David A
Publicado 2009

Crystal structures of the GH18 domain of the bifunctional peroxiredoxin–chitinase CotE from Clostridium difficile

por Whittingham, Jean L., Hanai, Shumpei, Brannigan, James A., Ferreira, William T., Dodson, Eleanor J., Turkenburg, Johan P., Cartwright, Jared, Cutting, Simon M., Wilkinson, Anthony J.
Publicado 2020

Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum

por Boucher, Ian W, McMillan, Paul J, Gabrielsen, Mads, Akerman, Susan E, Brannigan, James A, Schnick, Claudia, Brzozowski, Andrzej M, Wilkinson, Anthony J, Müller, Sylke
Publicado 2006

Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors

por Brannigan, James A., Roberts, Shirley M., Bell, Andrew S., Hutton, Jennie A., Hodgkinson, Michael R., Tate, Edward W., Leatherbarrow, Robin J., Smith, Deborah F., Wilkinson, Anthony J.
Publicado 2014

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

por Thinon, Emmanuelle, Serwa, Remigiusz A., Broncel, Malgorzata, Brannigan, James A., Brassat, Ute, Wright, Megan H., Heal, William P., Wilkinson, Anthony J., Mann, David J., Tate, Edward W.
Publicado 2014

The Orthologue of Sjögren's Syndrome Nuclear Autoantigen 1 (SSNA1) in Trypanosoma brucei Is an Immunogenic Self-Assembling Molecule

por Price, Helen P., Hodgkinson, Michael R., Curwen, Rachel S., MacLean, Lorna M., Brannigan, James A., Carrington, Mark, Smith, Barbara A., Ashford, David A., Stark, Meg, Smith, Deborah F.
Publicado 2012

Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

por Bell, Andrew S., Mills, James E., Williams, Gareth P., Brannigan, James A., Wilkinson, Anthony J., Parkinson, Tanya, Leatherbarrow, Robin J., Tate, Edward W., Holder, Anthony A., Smith, Deborah F.
Publicado 2012

Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase

por Rackham, Mark D., Yu, Zhiyong, Brannigan, James A., Heal, William P., Paape, Daniel, Barker, K. Victoria, Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Publicado 2015

Site-selective C–C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations

por Spears, Richard J., Brabham, Robin L., Budhadev, Darshita, Keenan, Tessa, McKenna, Sophie, Walton, Julia, Brannigan, James. A., Brzozowski, A. Marek, Wilkinson, Anthony J., Plevin, Michael, Fascione, Martin A.
Publicado 2018

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

por Cui, Huaqing, Carrero-Lérida, Juana, Silva, Ana P. G., Whittingham, Jean L., Brannigan, James A., Ruiz-Pérez, Luis M., Read, Kevin D., Wilson, Keith S., González-Pacanowska, Dolores, Gilbert, Ian H.
Publicado 2012

N-Myristoyltransferase from Leishmania donovani: Structural and Functional Characterisation of a Potential Drug Target for Visceral Leishmaniasis

por Brannigan, James A., Smith, Barbara A., Yu, Zhiyong, Brzozowski, Andrzej M., Hodgkinson, Michael R., Maroof, Asher, Price, Helen P., Meier, Franziska, Leatherbarrow, Robin J., Tate, Edward W., Smith, Deborah F., Wilkinson, Anthony J.
Publicado 2010

Structure-Based Design of Potent and Selective LeishmaniaN-Myristoyltransferase Inhibitors

por Hutton, Jennie A., Goncalves, Victor, Brannigan, James A., Paape, Daniel, Wright, Megan H., Waugh, Thomas M., Roberts, Shirley M., Bell, Andrew S., Wilkinson, Anthony J., Smith, Deborah F., Leatherbarrow, Robin J., Tate, Edward W.
Publicado 2014