Exploiting the complexity of the genome and transcriptome using pharmacogenomics towards personalized medicine

por Hoppe, Reiner, Brauch, Hiltrud, Kroetz, Deanna L, Esteller, Manel
Publicado 2011

Association of CYP2D6 metabolizer status with mammographic density change in response to tamoxifen treatment

por Li, Jingmei, Czene, Kamila, Brauch, Hiltrud, Schroth, Werner, Saladores, Pilar, Li, Yi, Humphreys, Keith, Hall, Per
Publicado 2013

ERBB4 Promoter Polymorphism Is Associated with Poor Distant Disease-Free Survival in High-Risk Early Breast Cancer

por Kurppa, Kari J., Rokavec, Matjaz, Sundvall, Maria, Kellokumpu-Lehtinen, Pirkko-Liisa, Joensuu, Heikki, Brauch, Hiltrud, Elenius, Klaus
Publicado 2014

Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer

por Hoppe, Reiner, Fan, Ping, Büttner, Florian, Winter, Stefan, Tyagi, Amit K., Cunliffe, Heather, Jordan, V. Craig, Brauch, Hiltrud
Publicado 2016

The formation of estrogen-like tamoxifen metabolites and their influence on enzyme activity and gene expression of ADME genes

por Johänning, Janina, Kröner, Patrick, Thomas, Maria, Zanger, Ulrich M., Nörenberg, Astrid, Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud, Schroth, Werner, Mürdter, Thomas E.
Publicado 2017

Epigenetic quantification of circulating immune cells in peripheral blood of triple-negative breast cancer patients

por Manoochehri, Mehdi, Hielscher, Thomas, Borhani, Nasim, Gerhäuser, Clarissa, Fletcher, Olivia, Swerdlow, Anthony J., Ko, Yon-Dschun, Brauch, Hiltrud, Brüning, Thomas, Hamann, Ute
Publicado 2021

Cancer-Associated Intermediate Conductance Ca(2+)-Activated K(+) Channel K(Ca)3.1

por Mohr, Corinna J., Steudel, Friederike A., Gross, Dominic, Ruth, Peter, Lo, Wing-Yee, Hoppe, Reiner, Schroth, Werner, Brauch, Hiltrud, Huber, Stephan M., Lukowski, Robert
Publicado 2019

Improved Prediction of Endoxifen Metabolism by CYP2D6 Genotype in Breast Cancer Patients Treated with Tamoxifen

por Schroth, Werner, Winter, Stefan, Mürdter, Thomas, Schaeffeler, Elke, Eccles, Diana, Eccles, Bryony, Chowbay, Balram, Khor, Chiea C., Tfayli, Arafat, Zgheib, Nathalie K., Eichelbaum, Michel, Schwab, Matthias, Brauch, Hiltrud
Publicado 2017

Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer

por Volpato, Milene, Cummings, Michele, Shaaban, Abeer M., Abderrahman, Balkees, Hull, Mark A., Maximov, Philipp Y., Broom, Bradley M., Hoppe, Reiner, Fan, Ping, Brauch, Hiltrud, Jordan, V. Craig, Speirs, Valerie
Publicado 2020

SK4 channels modulate Ca(2+) signalling and cell cycle progression in murine breast cancer

por Steudel, Friederike A., Mohr, Corinna J., Stegen, Benjamin, Nguyen, Hoang Y., Barnert, Andrea, Steinle, Marc, Beer‐Hammer, Sandra, Koch, Pierre, Lo, Wing‐Yee, Schroth, Werner, Hoppe, Reiner, Brauch, Hiltrud, Ruth, Peter, Huber, Stephan M., Lukowski, Robert
Publicado 2017

(Z)-Endoxifen and Early Recurrence of Breast Cancer: An Explorative Analysis in a Prospective Brazilian Study

por Almeida, Thais, Schroth, Werner, Nardin, Jeanine, Mürdter, Thomas E., Winter, Stefan, Picolotto, Solane, Hoppe, Reiner, Kogin, Jenifer, Gaio, Elisa, Dasenbrock, Angela, Skrsypcsak, Raquel Cristina, de Noronha, Lucia, Schwab, Matthias, Brauch, Hiltrud, Casali-da-Rocha, José Claudio
Publicado 2022

The Influences of Adherence to Tamoxifen and CYP2D6 Pharmacogenetics on Plasma Concentrations of the Active Metabolite (Z)‐Endoxifen in Breast Cancer

por Nardin, Jeanine Marie, Schroth, Werner, Almeida, Thais Abreu, Mürdter, Thomas, Picolotto, Solane, Vendramini, Evelyn Castillo Lima, Hoppe, Reiner, Kogin, Jenifer Primon, Miqueleto, Diandra, de Moraes, Silvia Dark Robaskievicz, Schwab, Matthias, Pecoits‐Filho, Roberto Flavio, Brauch, Hiltrud, Casali‐da‐Rocha, José Claudio
Publicado 2019

Association of the CHEK2 c.1100delC variant, radiotherapy, and systemic treatment with contralateral breast cancer risk and breast cancer-specific survival

por Morra, Anna, Schreurs, Maartje A. C., Andrulis, Irene L., Anton-Culver, Hoda, Augustinsson, Annelie, Beckmann, Matthias W., Behrens, Sabine, Bojesen, Stig E., Bolla, Manjeet K., Brauch, Hiltrud, Broeks, Annegien, Buys, Saundra S., Camp, Nicola J., Castelao, Jose E., Cessna, Melissa H., Chang-Claude, Jenny, Chung, Wendy K.
Publicado 2023

The UGT1A6_19_GG genotype is a breast cancer risk factor

por Justenhoven, Christina, Obazee, Ofure, Winter, Stefan, Rabstein, Sylvia, Lotz, Anne, Harth, Volker, Pesch, Beate, Brüning, Thomas, Baisch, Christian, Hartikainen, Jaana M., Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Winqvist, Robert, Pylkäs, Katri, Jukkola-Vuorinen, Arja, Grip, Mervi, Fasching, Peter A., Beckmann, Matthias, Ekici, Arif B., Hein, Alexander, Hall, Per, Li, Jingmei, Chang-Claude, Jenny, Flesch-Janys, Dieter, Seibold, Petra, Rudolph, Anja, Hamann, Ute, Ko, Yon-Dschun, Brauch, Hiltrud
Publicado 2013

Triple-Negative Breast Cancer Risk Genes Identified by Multigene Hereditary Cancer Panel Testing

por Shimelis, Hermela, LaDuca, Holly, Hu, Chunling, Hart, Steven N, Na, Jie, Thomas, Abigail, Akinhanmi, Margaret, Moore, Raymond M, Brauch, Hiltrud, Cox, Angela, Eccles, Diana M, Ewart-Toland, Amanda, Fasching, Peter A, Fostira, Florentia, Garber, Judy, Godwin, Andrew K, Konstantopoulou, Irene, Nevanlinna, Heli, Sharma, Priyanka, Yannoukakos, Drakoulis, Yao, Song, Feng, Bing-Jian, Tippin Davis, Brigette, Lilyquist, Jenna, Pesaran, Tina, Goldgar, David E, Polley, Eric C, Dolinsky, Jill S, Couch, Fergus J
Publicado 2018

Polymorphisms in genes of melatonin biosynthesis and signaling support the light-at-night hypothesis for breast cancer

por Wichert, Katharina, Hoppe, Reiner, Ickstadt, Katja, Behrens, Thomas, Winter, Stefan, Herold, Robert, Terschüren, Claudia, Lo, Wing-Yee, Guénel, Pascal, Truong, Thérèse, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Michailidou, Kyriaki, Lush, Michael, Andrulis, Irene L., Brenner, Hermann, Chang-Claude, Jenny, Cox, Angela, Cross, Simon S., Czene, Kamila, Eriksson, Mikael, Figueroa, Jonine D., García-Closas, Montserrat, Goldberg, Mark S., Hamann, Ute, He, Wei, Holleczek, Bernd, Hopper, John L., Jakubowska, Anna, Ko, Yon-Dschun, Lubiński, Jan, Mulligan, Anna Marie, Obi, Nadia, Rhenius, Valerie, Shah, Mitul, Shu, Xiao-Ou, Simard, Jacques, Southey, Melissa C., Zheng, Wei, Dunning, Alison M., Pharoah, Paul D. P., Hall, Per, Easton, Douglas F., Brüning, Thomas, Brauch, Hiltrud, Harth, Volker, Rabstein, Sylvia
Publicado 2023

Gene–environment interactions involving functional variants: Results from the Breast Cancer Association Consortium

por Barrdahl, Myrto, Rudolph, Anja, Hopper, John L., Southey, Melissa C., Broeks, Annegien, Fasching, Peter A., Beckmann, Matthias W., Gago‐Dominguez, Manuela, Castelao, J. Esteban, Guénel, Pascal, Truong, Thérèse, Bojesen, Stig E., Gapstur, Susan M., Gaudet, Mia M., Brenner, Hermann, Arndt, Volker, Brauch, Hiltrud, Hamann, Ute, Mannermaa, Arto, Lambrechts, Diether, Jongen, Lynn, Flesch‐Janys, Dieter, Thoene, Kathrin, Couch, Fergus J., Giles, Graham G., Simard, Jacques, Goldberg, Mark S., Figueroa, Jonine, Michailidou, Kyriaki, Bolla, Manjeet K., Dennis, Joe, Wang, Qin, Eilber, Ursula, Behrens, Sabine, Czene, Kamila, Hall, Per, Cox, Angela, Cross, Simon, Swerdlow, Anthony, Schoemaker, Minouk J., Dunning, Alison M., Kaaks, Rudolf, Pharoah, Paul D.P., Schmidt, Marjanka, Garcia‐Closas, Montserrat, Easton, Douglas F., Milne, Roger L., Chang‐Claude, Jenny
Publicado 2017

Genetic modifiers of CHEK2*1100delC associated breast cancer risk

por Muranen, Taru A., Greco, Dario, Blomqvist, Carl, Aittomäki, Kristiina, Khan, Sofia, Hogervorst, Frans, Verhoef, Senno, Pharoah, Paul D.P., Dunning, Alison M., Shah, Mitul, Luben, Robert, Bojesen, Stig E., Nordestgaard, Børge G., Schoemaker, Minouk, Swerdlow, Anthony, García-Closas, Montserrat, Figueroa, Jonine, Dörk, Thilo, Bogdanova, Natalia V., Hall, Per, Li, Jingmei, Khusnutdinova, Elza, Bermisheva, Marina, Kristensen, Vessela, Borresen-Dale, Anne-Lise, Peto, Julian, dos Santos Silva, Isabel, Couch, Fergus J., Olson, Janet E., Hillemans, Peter, Park-Simon, Tjoung-Won, Brauch, Hiltrud, Hamann, Ute, Burwinkel, Barbara, Marme, Frederik, Meindl, Alfons, Schmutzler, Rita K., Cox, Angela, Cross, Simon S., Sawyer, Elinor J., Tomlinson, Ian, Lambrechts, Diether, Moisse, Matthieu, Lindblom, Annika, Margolin, Sara, Hollestelle, Antoinette, Martens, John W.M., Fasching, Peter A., Beckmann, Matthias W., Andrulis, Irene L., Knight, Julia A., Anton-Culver, Hoda, Ziogas, Argyrios, Giles, Graham G., Milne, Roger L., Brenner, Hermann, Arndt, Volker, Mannermaa, Arto, Kosma, Veli-Matti, Chang-Claude, Jenny, Rudolph, Anja, Devilee, Peter, Seynaeve, Caroline, Hopper, John L., Southey, Melissa C., John, Esther M., Whittemore, Alice S., Bolla, Manjeet K., Wang, Qin, Michailidou, Kyriaki, Dennis, Joe, Easton, Douglas F., Schmidt, Marjanka K., Nevanlinna, Heli
Publicado 2016

Reproductive profiles and risk of breast cancer subtypes: a multi-center case-only study

por Brouckaert, Olivier, Rudolph, Anja, Laenen, Annouschka, Keeman, Renske, Bolla, Manjeet K., Wang, Qin, Soubry, Adelheid, Wildiers, Hans, Andrulis, Irene L., Arndt, Volker, Beckmann, Matthias W., Benitez, Javier, Blomqvist, Carl, Bojesen, Stig E., Brauch, Hiltrud, Brennan, Paul, Brenner, Hermann, Chenevix-Trench, Georgia, Choi, Ji-Yeob, Cornelissen, Sten, Couch, Fergus J., Cox, Angela, Cross, Simon S., Czene, Kamila, Eriksson, Mikael, Fasching, Peter A., Figueroa, Jonine, Flyger, Henrik, Giles, Graham G., González-Neira, Anna, Guénel, Pascal, Hall, Per, Hollestelle, Antoinette, Hopper, John L., Ito, Hidemi, Jones, Michael, Kang, Daehee, Knight, Julia A., Kosma, Veli-Matti, Li, Jingmei, Lindblom, Annika, Lilyquist, Jenna, Lophatananon, Artitaya, Mannermaa, Arto, Manoukian, Siranoush, Margolin, Sara, Matsuo, Keitaro, Muir, Kenneth, Nevanlinna, Heli, Peterlongo, Paolo, Pylkäs, Katri, Saajrang, Suleeporn, Seynaeve, Caroline, Shen, Chen-Yang, Shu, Xiao-Ou, Southey, Melissa C., Swerdlow, Anthony, Teo, Soo-Hwang, Tollenaar, Rob A. E. M., Truong, Thérèse, Tseng, Chiu-chen, van den Broek, Alexandra J., van Deurzen, Carolien H. M., Winqvist, Robert, Wu, Anna H., Yip, Cheng Har, Yu, Jyh-Cherng, Zheng, Wei, Milne, Roger L., Pharoah, Paul D. P., Easton, Douglas F., Schmidt, Marjanka K., Garcia-Closas, Montserrat, Chang-Claude, Jenny, Lambrechts, Diether, Neven, Patrick
Publicado 2017

Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses

por Painter, Jodie N., O'Mara, Tracy A., Morris, Andrew P., Cheng, Timothy H. T., Gorman, Maggie, Martin, Lynn, Hodson, Shirley, Jones, Angela, Martin, Nicholas G., Gordon, Scott, Henders, Anjali K., Attia, John, McEvoy, Mark, Holliday, Elizabeth G., Scott, Rodney J., Webb, Penelope M., Fasching, Peter A., Beckmann, Matthias W., Ekici, Arif B., Hein, Alexander, Rübner, Matthias, Hall, Per, Czene, Kamila, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo, Lambrechts, Diether, Amant, Frederic, Annibali, Daniela, Depreeuw, Jeroen, Vanderstichele, Adriaan, Goode, Ellen L., Cunningham, Julie M., Dowdy, Sean C., Winham, Stacey J., Trovik, Jone, Hoivik, Erling, Werner, Henrica M. J., Krakstad, Camilla, Ashton, Katie, Otton, Geoffrey, Proietto, Tony, Tham, Emma, Mints, Miriam, Ahmed, Shahana, Healey, Catherine S., Shah, Mitul, Pharoah, Paul D. P., Dunning, Alison M., Dennis, Joe, Bolla, Manjeet K., Michailidou, Kyriaki, Wang, Qin, Tyrer, Jonathan P., Hopper, John L., Peto, Julian, Swerdlow, Anthony J., Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Chang‐Claude, Jenny, Couch, Fergus J., Giles, Graham G., Kristensen, Vessela N., Cox, Angela, Zondervan, Krina T., Nyholt, Dale R., MacGregor, Stuart, Montgomery, Grant W., Tomlinson, Ian, Easton, Douglas F., Thompson, Deborah J., Spurdle, Amanda B.
Publicado 2018