Preclinical Patient-Derived Culture Models for Personalized Treatment of Pancreatic Cancer: A Dream of the Future or Useful Practice?

por Braun, Rüdiger, Ungefroren, Hendrik
Publicado 2023

TAp73 Inhibits EMT and Cell Migration in Pancreatic Cancer Cells through Promoting SMAD4 Expression and SMAD4-Dependent Inhibition of ERK Activation

por Ungefroren, Hendrik, Konukiewitz, Björn, Braun, Rüdiger, Wellner, Ulrich Friedrich, Lehnert, Hendrik, Marquardt, Jens-Uwe
Publicado 2023

Elucidation of the Role of SMAD4 in Epithelial–Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancr...

por Ungefroren, Hendrik, Konukiewitz, Björn, Braun, Rüdiger, Wellner, Ulrich Friedrich, Keck, Tobias, Marquardt, Jens-Uwe
Publicado 2023

Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Inv...

por Ungefroren, Hendrik, Braun, Rüdiger, Lapshyna, Olha, Konukiewitz, Björn, Wellner, Ulrich F., Lehnert, Hendrik, Marquardt, Jens-Uwe
Publicado 2022

A Comparative Endocrine Trans-Differentiation Approach to Pancreatic Ductal Adenocarcinoma Cells with Different EMT Phenotypes Identifies Quasi-Mesenchymal Tumor Cells as Those wit...

por Schmidtlein, Paula M., Volz, Clara, Braun, Rüdiger, Thürling, Isabel, Lapshyna, Olha, Wellner, Ulrich F., Konukiewitz, Björn, Lehnert, Hendrik, Marquardt, Jens-Uwe, Ungefroren, Hendrik
Publicado 2021

Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regu...

por Schmidtlein, Paula Marie, Volz, Clara, Hackel, Alexander, Thürling, Isabel, Castven, Darko, Braun, Rüdiger, Wellner, Ulrich Friedrich, Konukiewitz, Björn, Riemekasten, Gabriela, Lehnert, Hendrik, Marquardt, Jens-Uwe, Ungefroren, Hendrik
Publicado 2021

Single Chromosome Aneuploidy Induces Genome-Wide Perturbation of Nuclear Organization and Gene Expression

por Braun, Rüdiger, Ronquist, Scott, Wangsa, Darawalee, Chen, Haiming, Anthuber, Lena, Gemoll, Timo, Wangsa, Danny, Koparde, Vishal, Hunn, Cynthia, Habermann, Jens K., Heselmeyer-Haddad, Kerstin, Rajapakse, Indika, Ried, Thomas
Publicado 2019

The Quasimesenchymal Pancreatic Ductal Epithelial Cell Line PANC-1—A Useful Model to Study Clonal Heterogeneity and EMT Subtype Shifting

por Ungefroren, Hendrik, Thürling, Isabel, Färber, Benedikt, Kowalke, Tanja, Fischer, Tanja, De Assis, Leonardo Vinícius Monteiro, Braun, Rüdiger, Castven, Darko, Oster, Henrik, Konukiewitz, Björn, Wellner, Ulrich Friedrich, Lehnert, Hendrik, Marquardt, Jens-Uwe
Publicado 2022

Molecular profiling and specific targeting of gemcitabine-resistant subclones in heterogeneous pancreatic cancer cell populations

por Färber, Benedikt, Lapshyna, Olga, Künstner, Axel, Kohl, Michael, Sauer, Thorben, Bichmann, Kira, Heckelmann, Benjamin, Watzelt, Jessica, Honselmann, Kim, Bolm, Louisa, ten Winkel, Meike, Busch, Hauke, Ungefroren, Hendrik, Keck, Tobias, Gemoll, Timo, Wellner, Ulrich F., Braun, Rüdiger
Publicado 2023

Survival Outcome and Prognostic Factors for Pancreatic Acinar Cell Carcinoma: Retrospective Analysis from the German Cancer Registry Group

por Petrova, Ekaterina, Wellner, Joachim, Nording, Anne K., Braun, Rüdiger, Honselmann, Kim C., Bolm, Louisa, Hummel, Richard, Klinkhammer-Schalke, Monika, Zeissig, Sylke Ruth, Kleihues van Tol, Kees, Timme-Bronsert, Sylvia, Bronsert, Peter, Zemskov, Sergey, Keck, Tobias, Wellner, Ulrich Friedrich
Publicado 2021

Prognostic factors after resection of locally advanced non-functional pancreatic neuroendocrine neoplasm: an analysis from the German Cancer Registry Group of the Society of German...

por Abdalla, Thaer S. A., Klinkhammer-Schalke, Monika, Zeissig, Sylke Ruth, Tol, Kees Kleihues-van, Honselmann, Kim C., Braun, Rüdiger, Bolm, Louisa, Lapshyn, Hryhoriy, Litkevych, Stanislav, Zemskov, Sergii, Begum, Nehara, Kulemann, Birte, Hummel, Richard, Wellner, Ulrich Friedrich, Keck, Tobias, Deichmann, Steffen
Publicado 2023

Clinical Outcome and Prognostic Factors of Pancreatic Adenosquamous Carcinoma Compared to Ductal Adenocarcinoma—Results from the German Cancer Registry Group

por Braun, Rüdiger, Klinkhammer-Schalke, Monika, Zeissig, Sylke Ruth, Kleihus van Tol, Kees, Bolm, Louisa, Honselmann, Kim C., Petrova, Ekaterina, Lapshyn, Hryhoriy, Deichmann, Steffen, Abdalla, Thaer S. A., Heckelmann, Benjamin, Bronsert, Peter, Zemskov, Sergii, Hummel, Richard, Keck, Tobias, Wellner, Ulrich F.
Publicado 2022

Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells()

por Wangsa, Darawalee, Braun, Rüdiger, Stuelten, Christina H., Brown, Markus, Bauer, Kerry M., Emons, Georg, Weston, Leigh A., Hu, Yue, Yang, Howard H., Vila-Casadesús, Maria, Lee, Maxwell P., Brauer, Philip, Warner, Lidia, Upender, Madhvi, Hummon, Amanda B., Camps, Jordi, Ried, Thomas
Publicado 2019

Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response

por Braun, Rüdiger, Lapshyna, Olha, Watzelt, Jessica, Drenckhan, Maren, Künstner, Axel, Färber, Benedikt, Hael, Ahmed Ahmed Mohammed, Bolm, Louisa, Honselmann, Kim Christin, Konukiewitz, Björn, Castven, Darko, Spielmann, Malte, Gorantla, Sivahari Prasad, Busch, Hauke, Marquardt, Jens-Uwe, Keck, Tobias, Wellner, Ulrich Friedrich, Ungefroren, Hendrik
Publicado 2023

Hard wiring of normal tissue-specific chromosome-wide gene expression levels is an additional factor driving cancer type-specific aneuploidies

por Patkar, Sushant, Heselmeyer-Haddad, Kerstin, Auslander, Noam, Hirsch, Daniela, Camps, Jordi, Bronder, Daniel, Brown, Markus, Chen, Wei-Dong, Lokanga, Rachel, Wangsa, Darawalee, Wangsa, Danny, Hu, Yue, Lischka, Annette, Braun, Rüdiger, Emons, Georg, Ghadimi, B. Michael, Gaedcke, Jochen, Grade, Marian, Montagna, Cristina, Lazebnik, Yuri, Difilippantonio, Michael J., Habermann, Jens K., Auer, Gert, Ruppin, Eytan, Ried, Thomas
Publicado 2021