End-to-end approach for the characterization and control of product-related impurities in T cell bispecific antibody preparations

por Larivière, Laurent, Krüger, Julia Eva, von Hirschheydt, Thomas, Schlothauer, Tilman, Bray-French, Katharine, Bader, Martin, Runza, Valeria
Publicado 2023

Expanding the MAPPs Assay to Accommodate MHC-II Pan Receptors for Improved Predictability of Potential T Cell Epitopes

por Hartman, Katharina, Steiner, Guido, Siegel, Michel, Looney, Cary M., Hickling, Timothy P., Bray-French, Katharine, Springer, Sebastian, Marban-Doran, Céline, Ducret, Axel
Publicado 2023

Validation of a Dendritic Cell and CD4+ T Cell Restimulation Assay Contributing to the Immunogenicity Risk Evaluation of Biotherapeutics

por Siegel, Michel, Steiner, Guido, Franssen, Linnea C., Carratu, Francesca, Herron, James, Hartman, Katharina, Looney, Cary M., Ducret, Axel, Bray-French, Katharine, Rohr, Olivier, Hickling, Timothy P., Smith, Noel, Marban-Doran, Céline
Publicado 2022

Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice

por Egli, Jerome, Heiler, Stefan, Weber, Felix, Steiner, Guido, Schwandt, Timo, Bray-French, Katharine, Klein, Christian, Fenn, Sebastian, Lotz, Gregor P., Opolka-Hoffmann, Eugenia, Kraft, Thomas E., Petersen, Laetitia, Moser, Rebecca, DeGeer, Jonathan, Siegel, Michel, Finke, Daniela, Bessa, Juliana, Iglesias, Antonio
Publicado 2022