Crystal structure of the Rho-associated coiled-coil kinase 2 inhibitor belumosudil bound to CK2α

por Brear, Paul, Hyvönen, Marko
Publicado 2022

Evolution of protease activation and specificity via alpha-2-macroglobulin-mediated covalent capture

por Knyphausen, Philipp, Rangel Pereira, Mariana, Brear, Paul, Hyvönen, Marko, Jermutus, Lutz, Hollfelder, Florian
Publicado 2023

Affinity maturation of the RLIP76 Ral binding domain to inform the design of stapled peptides targeting the Ral GTPases

por Hurd, Catherine A., Brear, Paul, Revell, Jefferson, Ross, Sarah, Mott, Helen R., Owen, Darerca
Publicado 2020

Structure, Function and Regulation of a Second Pyruvate Kinase Isozyme in Pseudomonas aeruginosa

por Abdelhamid, Yassmin, Wang, Meng, Parkhill, Susannah L., Brear, Paul, Chee, Xavier, Rahman, Taufiq, Welch, Martin
Publicado 2021

From Data Mining of Chitinophaga sp. Genome to Enzyme Discovery of a Hyperthermophilic Metallocarboxypeptidase

por Fernandes, Gabriela Cabral, Sierra, Elwi Guillermo Machado, Brear, Paul, Pereira, Mariana Rangel, Lemos, Eliana G. M.
Publicado 2021

Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study

por Atkinson, Eleanor L., Iegre, Jessica, Brear, Paul D., Zhabina, Elizabeth A., Hyvönen, Marko, Spring, David R.
Publicado 2021

Development of small cyclic peptides targeting the CK2α/β interface

por Atkinson, Eleanor L., Iegre, Jessica, D’Amore, Claudio, Brear, Paul, Salvi, Mauro, Hyvönen, Marko, Spring, David R.
Publicado 2022

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

por De Fusco, Claudia, Brear, Paul, Iegre, Jessica, Georgiou, Kathy Hadje, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Publicado 2017

Systems-Wide Dissection of Organic Acid Assimilation in Pseudomonas aeruginosa Reveals a Novel Path To Underground Metabolism

por Dolan, Stephen K., Wijaya, Andre, Kohlstedt, Michael, Gläser, Lars, Brear, Paul, Silva-Rocha, Rafael, Wittmann, Christoph, Welch, Martin
Publicado 2022

Catabolite repression control protein antagonist, a novel player in Pseudomonas aeruginosa carbon catabolite repression control

por Sonnleitner, Elisabeth, Bassani, Flavia, Cianciulli Sesso, Anastasia, Brear, Paul, Lilic, Branislav, Davidovski, Lovro, Resch, Armin, Luisi, Ben F., Moll, Isabella, Bläsi, Udo
Publicado 2023

A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action

por Brear, Paul, De Fusco, Claudia, Atkinson, Eleanor L., Iegre, Jessica, Francis-Newton, Nicola J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R.
Publicado 2022

Novel non-ATP competitive small molecules targeting the CK2 α/β interface

por Brear, Paul, North, Andrew, Iegre, Jessica, Hadje Georgiou, Kathy, Lubin, Alexandra, Carro, Laura, Green, William, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Publicado 2018

Second-generation CK2α inhibitors targeting the αD pocket

por Iegre, Jessica, Brear, Paul, De Fusco, Claudia, Yoshida, Masao, Mitchell, Sophie L., Rossmann, Maxim, Carro, Laura, Sore, Hannah F., Hyvönen, Marko, Spring, David R.
Publicado 2018

Chain Alignment of Collagen I Deciphered using Computationally Designed Heterotrimers

por Jalan, Abhishek A., Sammon, Douglas, Hartgerink, Jeffrey D., Brear, Paul, Stott, Katherine, Hamaia, Samir W., Hunter, Emma J., Walker, Douglas R., Leitinger, Birgit, Farndale, Richard W.
Publicado 2020

Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction

por Iegre, Jessica, Brear, Paul, Baker, David J., Tan, Yaw Sing, Atkinson, Eleanor L., Sore, Hannah F., O' Donovan, Daniel H., Verma, Chandra S., Hyvönen, Marko, Spring, David R.
Publicado 2019

Specific inhibition of CK2α from an anchor outside the active site

por Brear, Paul, De Fusco, Claudia, Hadje Georgiou, Kathy, Francis-Newton, Nicola J., Stubbs, Christopher J., Sore, Hannah F., Venkitaraman, Ashok R., Abell, Chris, Spring, David R., Hyvönen, Marko
Publicado 2016

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

por Kufareva, Irina, Bestgen, Benoit, Brear, Paul, Prudent, Renaud, Laudet, Béatrice, Moucadel, Virginie, Ettaoussi, Mohamed, Sautel, Celine F., Krimm, Isabelle, Engel, Matthias, Filhol, Odile, Borgne, Marc Le, Lomberget, Thierry, Cochet, Claude, Abagyan, Ruben
Publicado 2019

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

por Zhou, Linna, Ishizaki, Hironori, Spitzer, Michaela, Taylor, Kerrie L., Temperley, Nicholas D., Johnson, Stephen L., Brear, Paul, Gautier, Philippe, Zeng, Zhiqiang, Mitchell, Amy, Narayan, Vikram, McNeil, Ewan M., Melton, David W., Smith, Terry K., Tyers, Mike, Westwood, Nicholas J., Patton, E. Elizabeth
Publicado 2012

ALDH2 Mediates 5-Nitrofuran Activity in Multiple Species

por Zhou, Linna, Ishizaki, Hironori, Spitzer, Michaela, Taylor, Kerrie L., Temperley, Nicholas D., Johnson, Stephen L., Brear, Paul, Gautier, Philippe, Zeng, Zhiqiang, Mitchell, Amy, Narayan, Vikram, McNeil, Ewan M., Melton, David W., Smith, Terry K., Tyers, Mike, Westwood, Nicholas J., Patton, E. Elizabeth
Publicado 2020

Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion

por Kidd, Sarah L., Fowler, Elaine, Reinhardt, Till, Compton, Thomas, Mateu, Natalia, Newman, Hector, Bellini, Dom, Talon, Romain, McLoughlin, Joseph, Krojer, Tobias, Aimon, Anthony, Bradley, Anthony, Fairhead, Michael, Brear, Paul, Díaz-Sáez, Laura, McAuley, Katherine, Sore, Hannah F., Madin, Andrew, O'Donovan, Daniel H., Huber, Kilian V. M., Hyvönen, Marko, von Delft, Frank, Dowson, Christopher G., Spring, David R.
Publicado 2020