Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy

por Pettinati, Ilaria, Brem, Jürgen, McDonough, Michael A., Schofield, Christopher J.
Publicado 2015

Will morphing boron-based inhibitors beat the β-lactamases?

por Krajnc, Alen, Lang, Pauline A, Panduwawala, Tharindi D, Brem, Jürgen, Schofield, Christopher J
Publicado 2019

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

por Pettinati, Ilaria, Brem, Jürgen, Lee, Sook Y., McHugh, Peter J., Schofield, Christopher J.
Publicado 2016

A Fluorescence‐Based Assay for Screening β‐Lactams Targeting the Mycobacterium tuberculosis Transpeptidase Ldt(Mt2)

por de Munnik, Mariska, Lohans, Christopher T., Langley, Gareth W., Bon, Corentin, Brem, Jürgen, Schofield, Christopher J.
Publicado 2019

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

por Lang, Pauline A., Leissing, Thomas M., Page, Malcolm G. P., Schofield, Christopher J., Brem, Jürgen
Publicado 2021

Use of ferrous iron by metallo-β-lactamases

por Cahill, Samuel T., Tarhonskaya, Hanna, Rydzik, Anna M., Flashman, Emily, McDonough, Michael A., Schofield, Christopher J., Brem, Jürgen
Publicado 2016

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

por Tooke, Catherine L., Hinchliffe, Philip, Lang, Pauline A., Mulholland, Adrian J., Brem, Jürgen, Schofield, Christopher J., Spencer, James
Publicado 2019

(19)F NMR Monitoring of Reversible Protein Post‐Translational Modifications: Class D β‐Lactamase Carbamylation and Inhibition

por van Groesen, Emma, Lohans, Christopher T., Brem, Jürgen, Aertker, Kristina M. J., Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2019

Monitoring Conformational Changes in the NDM-1 Metallo-β-lactamase by (19)F NMR Spectroscopy**

por Rydzik, Anna M, Brem, Jürgen, van Berkel, Sander S, Pfeffer, Inga, Makena, Anne, Claridge, Timothy D W, Schofield, Christopher J
Publicado 2014

A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation

por Lohans, Christopher T., van Groesen, Emma, Kumar, Kiran, Tooke, Catherine L., Spencer, James, Paton, Robert S., Brem, Jürgen, Schofield, Christopher J.
Publicado 2018

Monitoring protein-metal binding by (19)F NMR – a case study with the New Delhi metallo-β-lactamase 1

por Rydzik, Anna M., Brem, Jürgen, Chandler, Shane A., Benesch, Justin L. P., Claridge, Timothy D. W., Schofield, Christopher J.
Publicado 2020

Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates

por Farley, Alistair J. M., Ermolovich, Yuri, Calvopiña, Karina, Rabe, Patrick, Panduwawala, Tharindi, Brem, Jürgen, Björkling, Fredrik, Schofield, Christopher J.
Publicado 2021

Correction to “Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates”

por Farley, Alistair J. M., Ermolovich, Yuri, Calvopiña, Karina, Rabe, Patrick, Panduwawala, Tharindi, Brem, Jürgen, Björkling, Fredrik, Schofield, Christopher J.
Publicado 2021

Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors

por Lang, Pauline A., Raj, Ritu, Tumber, Anthony, Lohans, Christopher T., Rabe, Patrick, Robinson, Carol V., Brem, Jürgen, Schofield, Christopher J.
Publicado 2022

Cephalosporins inhibit human metallo β-lactamase fold DNA repair nucleases SNM1A and SNM1B/apollo

por Lee, Sook Y., Brem, Jürgen, Pettinati, Ilaria, Claridge, Timothy D. W., Gileadi, Opher, Schofield, Christopher J., McHugh, Peter J.
Publicado 2016

Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation

por Lohans, Christopher T., Freeman, Emily I., Groesen, Emma van, Tooke, Catherine L., Hinchliffe, Philip, Spencer, James, Brem, Jürgen, Schofield, Christopher J.
Publicado 2019

Targeting the Mycobacterium tuberculosis transpeptidase Ldt(Mt2) with cysteine-reactive inhibitors including ebselen

por de Munnik, Mariska, Lohans, Christopher T., Lang, Pauline A., Langley, Gareth W., Malla, Tika R., Tumber, Anthony, Schofield, Christopher J., Brem, Jürgen
Publicado 2019

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

por Lucic, Anka, Malla, Tika R., Calvopiña, Karina, Tooke, Catherine L., Brem, Jürgen, McDonough, Michael A., Spencer, James, Schofield, Christopher J.
Publicado 2022

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease

por Pettinati, Ilaria, Grzechnik, Pawel, Ribeiro de Almeida, Claudia, Brem, Jurgen, McDonough, Michael A, Dhir, Somdutta, Proudfoot, Nick J, Schofield, Christopher J
Publicado 2018

High-throughput screen with the l,d-transpeptidase Ldt(Mt2) of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors

por de Munnik, Mariska, Lang, Pauline A., De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H., Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J.
Publicado 2023