Chemogenomics for drug discovery: clinical molecules from open access chemical probes

por Quinlan, Robert B. A., Brennan, Paul E.
Publicado 2021

The Role of Protein Structural Analysis in the Next Generation Sequencing Era

por Yue, Wyatt W., Froese, D. Sean, Brennan, Paul E.
Publicado 2012

Targeting the Small GTPase Superfamily through Their Regulatory Proteins

por Gray, Janine L., von Delft, Frank, Brennan, Paul E.
Publicado 2020

TargetDB: A target information aggregation tool and tractability predictor

por De Cesco, Stephane, Davis, John B., Brennan, Paul E.
Publicado 2020

RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors

por Thompson, Andrew P., Bitsina, Christina, Gray, Janine L., von Delft, Frank, Brennan, Paul E.
Publicado 2021

Chemical probes and inhibitors of bromodomains outside the BET family

por Moustakim, Moses, Clark, Peter G. K., Hay, Duncan A., Dixon, Darren J., Brennan, Paul E.
Publicado 2016

Development of Selective ADAMTS-5 Peptide Substrates to Monitor Proteinase Activity

por Fowkes, Milan M., Troeberg, Linda, Brennan, Paul E., Vincent, Tonia L., Meldal, Morten, Lim, Ngee H.
Publicado 2023

Identifying Small‐Molecule Binding Sites for Epigenetic Proteins at Domain–Domain Interfaces

por Bowkett, David, Talon, Romain, Tallant, Cynthia, Schofield, Chris, von Delft, Frank, Knapp, Stefan, Bruton, Gordon, Brennan, Paul E.
Publicado 2018

Imaging articular cartilage in osteoarthritis using targeted peptide radiocontrast agents

por Fowkes, Milan M., Das Neves Borges, Patricia, Cacho-Nerin, Fernando, Brennan, Paul E., Vincent, Tonia L., Lim, Ngee H.
Publicado 2022

Novel Starting Points for Human Glycolate Oxidase Inhibitors, Revealed by Crystallography-Based Fragment Screening

por Mackinnon, Sabrina R., Bezerra, Gustavo A., Krojer, Tobias, Szommer, Tamas, von Delft, Frank, Brennan, Paul E., Yue, Wyatt W.
Publicado 2022

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors

por Schuller, Marion, Zarganes-Tzitzikas, Tryfon, Bennett, James, De Cesco, Stephane, Fearon, Daren, von Delft, Frank, Fedorov, Oleg, Brennan, Paul E., Ahel, Ivan
Publicado 2023

Structure-Based Identification of Inhibitory Fragments Targeting the p300/CBP-Associated Factor Bromodomain

por Chaikuad, Apirat, Lang, Steffen, Brennan, Paul E., Temperini, Claudia, Fedorov, Oleg, Hollander, Johan, Nachane, Ruta, Abell, Chris, Müller, Susanne, Siegal, Gregg, Knapp, Stefan
Publicado 2016

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

por Roberts, Thomas C., Etxaniz, Usue, Dall’Agnese, Alessandra, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Brennan, Paul E., Wood, Matthew J. A., Puri, Pier Lorenzo
Publicado 2017

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

por Nizami, Sohaib, Millar, Val, Arunasalam, Kanisa, Zarganes-Tzitzikas, Tryfon, Brough, David, Tresadern, Gary, Brennan, Paul E., Davis, John B., Ebner, Daniel, Di Daniel, Elena
Publicado 2021

Author Correction: A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation

por Nizami, Sohaib, Millar, Val, Arunasalam, Kanisa, Zarganes-Tzitzikas, Tryfon, Brough, David, Tresadern, Gary, Brennan, Paul E., Davis, John B., Ebner, Daniel, Di Daniel, Elena
Publicado 2021

A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain

por Cox, Oakley B., Krojer, Tobias, Collins, Patrick, Monteiro, Octovia, Talon, Romain, Bradley, Anthony, Fedorov, Oleg, Amin, Jahangir, Marsden, Brian D., Spencer, John, von Delft, Frank, Brennan, Paul E.
Publicado 2016

Discovery of a Chemical Tool Inhibitor Targeting the Bromodomains of TRIM24 and BRPF

por Bennett, James, Fedorov, Oleg, Tallant, Cynthia, Monteiro, Octovia, Meier, Julia, Gamble, Vicky, Savitsky, Pavel, Nunez-Alonso, Graciela A, Haendler, Bernard, Rogers, Catherine, Brennan, Paul E., Müller, Susanne, Knapp, Stefan
Publicado 2015

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

por Sutherell, Charlotte L., Tallant, Cynthia, Monteiro, Octovia P., Yapp, Clarence, Fuchs, Julian E., Fedorov, Oleg, Siejka, Paulina, Müller, Suzanne, Knapp, Stefan, Brenton, James D., Brennan, Paul E., Ley, Steven V.
Publicado 2016

Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

por Mackinnon, Sabrina R., Krojer, Tobias, Foster, William R., Diaz-Saez, Laura, Tang, Manshu, Huber, Kilian V. M., von Delft, Frank, Lai, Kent, Brennan, Paul E., Arruda Bezerra, Gustavo, Yue, Wyatt W.
Publicado 2021

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor

por England, Katherine S., Tumber, Anthony, Krojer, Tobias, Scozzafava, Giuseppe, Ng, Stanley S., Daniel, Michelle, Szykowska, Aleksandra, Che, KaHing, von Delft, Frank, Burgess-Brown, Nicola A., Kawamura, Akane, Schofield, Christopher J., Brennan, Paul E.
Publicado 2014