Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells

por Prytkova, Iya, Brennand, Kristen J.
Publicado 2017

If there is not one cure for schizophrenia, there may be many

por Seah, Carina, Brennand, Kristen J.
Publicado 2020

Modeling psychiatric disorders through reprogramming

por Brennand, Kristen J., Gage, Fred H.
Publicado 2012

Better together: Non-additive interactions between schizophrenia risk genes

por Deans, P.J. Michael, Brennand, Kristen J.
Publicado 2023

Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease

por Kocerha, Jannet, Dwivedi, Yogesh, Brennand, Kristen J
Publicado 2015

From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease

por Ho, Seok-Man, Topol, Aaron, Brennand, Kristen J
Publicado 2015

The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening

por Gonzalez, David M., Gregory, Jill, Brennand, Kristen J.
Publicado 2017

New considerations for hiPSC-based models of neuropsychiatric disorders

por Hoffman, Gabriel E., Schrode, Nadine, Flaherty, Erin, Brennand, Kristen J.
Publicado 2018

Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders

por Schadt, Eric E., Buchanan, Sean, Brennand, Kristen J., Merchant, Kalpana M.
Publicado 2014

Dopaminergic differentiation of schizophrenia hiPSCs

por Hartley, Brigham J., Tran, Ngoc, Ladran, Ian, Reggio, Kathryn, Brennand, Kristen J.
Publicado 2015

Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells

por LaMarca, Elizabeth A., Powell, Samuel K., Akbarian, Schahram, Brennand, Kristen J.
Publicado 2018

Type I interferon response impairs differentiation potential of pluripotent stem cells

por Eggenberger, Julie, Blanco-Melo, Daniel, Panis, Maryline, Brennand, Kristen J., tenOever, Benjamin R.
Publicado 2019

Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons

por Hook, Vivian, Brennand, Kristen J., Kim, Yongsung, Toneff, Thomas, Funkelstein, Lydiane, Lee, Kelly C., Ziegler, Michael, Gage, Fred H.
Publicado 2014

Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings

por Hicks, Emily M., Seah, Carina, Cote, Alanna, Marchese, Shelby, Brennand, Kristen J., Nestler, Eric J., Girgenti, Matthew J., Huckins, Laura M.
Publicado 2023

Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity

por Flaherty, Erin, Deranieh, Rania M., Artimovich, Elena, Lee, Inkyu S., Siegel, Arthur J., Levy, Deborah L., Nestor, Michael W., Brennand, Kristen J.
Publicado 2017

GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis

por Kajiwara, Yuji, Wang, Erming, Wang, Minghui, Sin, Wun Chey, Brennand, Kristen J., Schadt, Eric, Naus, Christian C., Buxbaum, Joseph, Zhang, Bin
Publicado 2018

Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome

por Talvio, Karo, Minkeviciene, Rimante, Townsley, Kayla G., Achuta, Venkat Swaroop, Huckins, Laura M., Corcoran, Padraic, Brennand, Kristen J., Castrén, Maija L.
Publicado 2022

A computational tool (H-MAGMA) for improved prediction of brain disorder risk genes by incorporating brain chromatin interaction profiles

por Sey, Nancy Y. A, Hu, Benxia, Mah, Won, Fauni, Harper, McAfee, Jessica Caitlin, Rajarajan, Prashanth, Brennand, Kristen J, Akbarian, Schahram, Won, Hyejung
Publicado 2020

Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains

por Hoffman, Gabriel E., Hartley, Brigham J., Flaherty, Erin, Ladran, Ian, Gochman, Peter, Ruderfer, Douglas M., Stahl, Eli A., Rapoport, Judith, Sklar, Pamela, Brennand, Kristen J.
Publicado 2017

THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders

por Guennewig, Boris, Bitar, Maina, Obiorah, Ifeanyi, Hanks, James, O’Brien, Elizabeth A., Kaczorowski, Dominik C., Hurd, Yasmin L., Roussos, Panos, Brennand, Kristen J., Barry, Guy
Publicado 2018