IgG Fc engineering to modulate antibody effector functions

por Wang, Xinhua, Mathieu, Mary, Brezski, Randall J.
Publicado 2017

The Origins, Specificity, and Potential Biological Relevance of Human Anti-IgG Hinge Autoantibodies

por Brezski, Randall J., Knight, David M., Jordan, Robert E.
Publicado 2011

An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions

por Kinder, Michelle, Greenplate, Allison R, Strohl, William R, Jordan, Robert E, Brezski, Randall J
Publicado 2015

9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland

por Reichert, Janice M, Beck, Alain, Lugovskoy, Alexey A, Wurch, Thierry, Coats, Steven, Brezski, Randall J
Publicado 2014

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy

por Fan, Xuejun, Brezski, Randall J, Fa, Ming, Deng, Hui, Oberholtzer, Allison, Gonzalez, Anneliese, Dubinsky, William P, Strohl, William R, Jordan, Robert E, Zhang, Ningyan, An, Zhiqiang
Publicado 2012

FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric‐coated capsules in cynomolgus macaques

por Muzammil, Salman, Mabus, John R., Cooper, Philip R., Brezski, Randall J., Bement, Courtney B., Perkinson, Rob, Huebert, Norman D., Thompson, Suzanne, Levine, Dalia, Kliwinski, Connie, Bradley, Dino, Hornby, Pamela J.
Publicado 2016

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

por Yang, Yanli, Yeh, Sherry H., Madireddi, Shravan, Matochko, Wadim L., Gu, Chen, Pacheco Sanchez, Patricia, Ultsch, Mark, De Leon Boenig, Gladys, Harris, Seth F., Leonard, Brandon, Scales, Suzie J., Zhu, Jing W., Christensen, Erin, Hang, Julie Q., Brezski, Randall J., Marsters, Scot, Ashkenazi, Avi, Sukumaran, Siddharth, Chiu, Henry, Cubas, Rafael, Kim, Jeong M., Lazar, Greg A.
Publicado 2019