Targeting cancer lactate metabolism with synergistic combinations of synthetic catalysts and monocarboxylate transporter inhibitors

por Bridgewater, Hannah E., Bolitho, Elizabeth M., Romero-Canelón, Isolda, Sadler, Peter J., Coverdale, James P. C.
Publicado 2023

Osmium–arene complexes with high potency towards Mycobacterium tuberculosis

por Coverdale, James P C, Guy, Collette S, Bridgewater, Hannah E, Needham, Russell J, Fullam, Elizabeth, Sadler, Peter J
Publicado 2021

The Epstein-Barr Virus-Encoded EBNA1 Protein Activates the Bone Morphogenic Protein (BMP) Signalling Pathway to Promote Carcinoma Cell Migration

por Bridgewater, Hannah E., Date, Kathryn L., O’Neil, John D., Hu, Chunfang, Arrand, John R., Dawson, Christopher W., Young, Lawrence S.
Publicado 2020

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake

por Coverdale, James P. C., van den Berg, Hugo A., Khazaipoul, Siavash, Bridgewater, Hannah E., Stewart, Alan J., Blindauer, Claudia A.
Publicado 2022

Tracking Reactions of Asymmetric Organo‐Osmium Transfer Hydrogenation Catalysts in Cancer Cells

por Bolitho, Elizabeth M., Coverdale, James P. C., Bridgewater, Hannah E., Clarkson, Guy J., Quinn, Paul D., Sanchez‐Cano, Carlos, Sadler, Peter J.
Publicado 2021

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

por Coverdale, James P. C., Bridgewater, Hannah E., Song, Ji-Inn, Smith, Nichola A., Barry, Nicolas P. E., Bagley, Ian, Sadler, Peter J., Romero-Canelón, Isolda
Publicado 2018

Dose- and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice

por Kumar, Swati A, Needham, Russell J, Abraham, Kristin, Bridgewater, Hannah E, Garbutt, Lauren A, Xandri-Monje, Helena, Dallmann, Robert, Perrier, Sebastien, Sadler, Peter J, Lévi, Francis
Publicado 2020

Glycoconjugated Metallohelices have Improved Nuclear Delivery and Suppress Tumour Growth In Vivo

por Song, Hualong, Allison, Simon J., Brabec, Viktor, Bridgewater, Hannah E., Kasparkova, Jana, Kostrhunova, Hana, Novohradsky, Vojtech, Phillips, Roger M., Pracharova, Jitka, Rogers, Nicola J., Shepherd, Samantha L., Scott, Peter
Publicado 2020

Ligand-centred redox activation of inert organoiridium anticancer catalysts

por Zhang, Wen-Ying, Banerjee, Samya, Hughes, George M., Bridgewater, Hannah E., Song, Ji-Inn, Breeze, Ben G., Clarkson, Guy J., Coverdale, James P. C., Sanchez-Cano, Carlos, Ponte, Fortuna, Sicilia, Emilia, Sadler, Peter J.
Publicado 2020

Metallodrugs are unique: opportunities and challenges of discovery and development

por Anthony, Elizabeth J., Bolitho, Elizabeth M., Bridgewater, Hannah E., Carter, Oliver W. L., Donnelly, Jane M., Imberti, Cinzia, Lant, Edward C., Lermyte, Frederik, Needham, Russell J., Palau, Marta, Sadler, Peter J., Shi, Huayun, Wang, Fang-Xin, Zhang, Wen-Ying, Zhang, Zijin
Publicado 2020