Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice

por Holter, Marlena M., Chirikjian, Margot K., Briere, Daniel A., Maida, Adriano, Sloop, Kyle W., Schoonjans, Kristina, Cummings, Bethany P.
Publicado 2020

The novel dual glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1 (GLP‐1) receptor agonist tirzepatide transiently delays gastric emptying similarly to select...

por Urva, Shweta, Coskun, Tamer, Loghin, Corina, Cui, Xuewei, Beebe, Emily, O'Farrell, Libbey, Briere, Daniel A., Benson, Charles, Nauck, Michael A., Haupt, Axel
Publicado 2020

GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function

por Lin, Hua V., Wang, Jingru, Wang, Jie, Li, Weiji, Wang, Xuesong, Alston, James T., Thomas, Melissa K., Briere, Daniel A., Syed, Samreen K., Efanov, Alexander M.
Publicado 2018

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice

por Briere, Daniel A., Ruan, Xiaoping, Cheng, Christine C., Siesky, Angela M., Fitch, Thomas E., Dominguez, Carmen, Sanfeliciano, Sonia Gutierrez, Montero, Carlos, Suen, Chen S., Xu, Yanping, Coskun, Tamer, Michael, M. Dodson
Publicado 2015

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

por Coskun, Tamer, Sloop, Kyle W., Loghin, Corina, Alsina-Fernandez, Jorge, Urva, Shweta, Bokvist, Krister B., Cui, Xuewei, Briere, Daniel A., Cabrera, Over, Roell, William C., Kuchibhotla, Uma, Moyers, Julie S., Benson, Charles T., Gimeno, Ruth E., D'Alessio, David A., Haupt, Axel
Publicado 2018

GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

por Samms, Ricardo J., Cosgrove, Richard, Snider, Brandy M., Furber, Ellen C., Droz, Brian A., Briere, Daniel A., Dunbar, James, Dogra, Mridula, Alsina-Fernandez, Jorge, Borner, Tito, De Jonghe, Bart C., Hayes, Matthew R., Coskun, Tamer, Sloop, Kyle W., Emmerson, Paul J., Ai, Minrong
Publicado 2022