Structural Basis for the Initiation of Glycosaminoglycan Biosynthesis by Human Xylosyltransferase 1

por Briggs, David C., Hohenester, Erhard
Publicado 2018

Crystallographic analysis of the laminin β2 short arm reveals how the LF domain is inserted into a regular array of LE domains

por Pulido, David, Briggs, David C., Hua, Jinwen, Hohenester, Erhard
Publicado 2017

The impact of AlphaFold2 on experimental structure solution

por Edich, Maximilian, Briggs, David C., Kippes, Oliver, Gao, Yunyun, Thorn, Andrea
Publicado 2022

Insights into Collagen Uptake by C-type Mannose Receptors from the Crystal Structure of Endo180 Domains 1–4

por Paracuellos, Patricia, Briggs, David C., Carafoli, Federico, Lončar, Tan, Hohenester, Erhard
Publicado 2015

Molecular mechanism of decision-making in glycosaminoglycan biosynthesis

por Sammon, Douglas, Krueger, Anja, Busse-Wicher, Marta, Morgan, Rhodri Marc, Haslam, Stuart M., Schumann, Benjamin, Briggs, David C., Hohenester, Erhard
Publicado 2023

Molecular Recognition of the Tes LIM2–3 Domains by the Actin-related Protein Arp7A

por Boëda, Batiste, Knowles, Phillip P., Briggs, David C., Murray-Rust, Judith, Soriano, Erika, Garvalov, Boyan K., McDonald, Neil Q., Way, Michael
Publicado 2011

Inter-α-inhibitor Impairs TSG-6-induced Hyaluronan Cross-linking

por Baranova, Natalia S., Foulcer, Simon J., Briggs, David C., Tilakaratna, Viranga, Enghild, Jan J., Milner, Caroline M., Day, Anthony J., Richter, Ralf P.
Publicado 2013

Structure of PLA2R reveals presentation of the dominant membranous nephropathy epitope and an immunogenic patch

por Fresquet, Maryline, Lockhart-Cairns, Michael P., Rhoden, Samuel J., Jowitt, Thomas A., Briggs, David C., Baldock, Clair, Brenchley, Paul E., Lennon, Rachel
Publicado 2022

Incorporation of Pentraxin 3 into Hyaluronan Matrices Is Tightly Regulated and Promotes Matrix Cross-linking

por Baranova, Natalia S., Inforzato, Antonio, Briggs, David C., Tilakaratna, Viranga, Enghild, Jan J., Thakar, Dhruv, Milner, Caroline M., Day, Anthony J., Richter, Ralf P.
Publicado 2014

Structural basis of laminin binding to the LARGE glycans on dystroglycan

por Briggs, David C., Yoshida-Moriguchi, Takako, Zheng, Tianqing, Venzke, David, Anderson, Mary, Strazzulli, Andrea, Moracci, Marco, Yu, Liping, Hohenester, Erhard, Campbell, Kevin P.
Publicado 2016

Homodimerization of the Lymph Vessel Endothelial Receptor LYVE-1 through a Redox-labile Disulfide Is Critical for Hyaluronan Binding in Lymphatic Endothelium

por Banerji, Suneale, Lawrance, William, Metcalfe, Clive, Briggs, David C., Yamauchi, Akira, Dushek, Omer, van der Merwe, P. Anton, Day, Anthony J., Jackson, David G.
Publicado 2016

Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

por Jones, Morgan, Beuron, Fabienne, Borg, Aaron, Nans, Andrea, Earl, Christopher P., Briggs, David C., Snijders, Ambrosius P., Bowles, Maureen, Morris, Edward P., Linch, Mark, McDonald, Neil Q.
Publicado 2020

Inter-α-inhibitor heavy chain-1 has an integrin-like 3D structure mediating immune regulatory activities and matrix stabilization during ovulation

por Briggs, David C., Langford-Smith, Alexander W. W., Birchenough, Holly L., Jowitt, Thomas A., Kielty, Cay M., Enghild, Jan J., Baldock, Clair, Milner, Caroline M., Day, Anthony J.
Publicado 2020

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

por Moccia, Marialuisa, Frett, Brendan, Zhang, Lingtian, Lakkaniga, Naga Rajiv, Briggs, David C., Chauhan, Rakhee, Brescia, Annalisa, Federico, Giorgia, Yan, Wei, Santoro, Massimo, McDonald, Neil Q., Li, Hong-yu, Carlomagno, Francesca
Publicado 2020

Metal Ion-dependent Heavy Chain Transfer Activity of TSG-6 Mediates Assembly of the Cumulus-Oocyte Matrix

por Briggs, David C., Birchenough, Holly L., Ali, Tariq, Rugg, Marilyn S., Waltho, Jon P., Ievoli, Elena, Jowitt, Thomas A., Enghild, Jan J., Richter, Ralf P., Salustri, Antonietta, Milner, Caroline M., Day, Anthony J.
Publicado 2015

A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan: USE OF DEFINED OLIGOSACCHARIDES TO PROBE STRUCTURE AND FUNCTION

por Higman, Victoria A., Briggs, David C., Mahoney, David J., Blundell, Charles D., Sattelle, Benedict M., Dyer, Douglas P., Green, Dixy E., DeAngelis, Paul L., Almond, Andrew, Milner, Caroline M., Day, Anthony J.
Publicado 2014

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

por Adams, Sarah E., Purkiss, Andrew G., Knowles, Phillip P., Nans, Andrea, Briggs, David C., Borg, Annabel, Earl, Christopher P., Goodman, Kerry M., Nawrotek, Agata, Borg, Aaron J., McIntosh, Pauline B., Houghton, Francesca M., Kjær, Svend, McDonald, Neil Q.
Publicado 2021

Metabolic precision labeling enables selective probing of O-linked N-acetylgalactosamine glycosylation

por Debets, Marjoke F., Tastan, Omur Y., Wisnovsky, Simon P., Malaker, Stacy A., Angelis, Nikolaos, Moeckl, Leonhard K. R., Choi, Junwon, Flynn, Helen, Wagner, Lauren J. S., Bineva-Todd, Ganka, Antonopoulos, Aristotelis, Cioce, Anna, Browne, William M., Li, Zhen, Briggs, David C., Douglas, Holly L., Hess, Gaelen T., Agbay, Anthony J., Roustan, Chloe, Kjaer, Svend, Haslam, Stuart M., Snijders, Ambrosius P., Bassik, Michael C., Moerner, W. E., Li, Vivian S. W., Bertozzi, Carolyn R., Schumann, Benjamin
Publicado 2020