Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19

por Eastman, Richard T., Roth, Jacob S., Brimacombe, Kyle R., Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D.
Publicado 2020

Correction to Remdesivir: A Review of Its Discovery and Development Leading to Human Clinical Trials for Treatment of COVID-19

por Eastman, Richard T., Roth, Jacob S., Brimacombe, Kyle R., Simeonov, Anton, Shen, Min, Patnaik, Samarjit, Hall, Matthew D.
Publicado 2020

PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose

por Tee, Sui Seng, Park, Jae Mo, Hurd, Ralph E., Brimacombe, Kyle R., Boxer, Matthew B., Massoud, Tarik F., Rutt, Brian K., Spielman, Daniel M.
Publicado 2017

Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells

por Sarin, Hemant, Kanevsky, Ariel S, Wu, Haitao, Brimacombe, Kyle R, Fung, Steve H, Sousa, Alioscka A, Auh, Sungyoung, Wilson, Colin M, Sharma, Kamal, Aronova, Maria A, Leapman, Richard D, Griffiths, Gary L, Hall, Matthew D
Publicado 2008

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

por Najm, Fadi J., Madhavan, Mayur, Zaremba, Anita, Shick, Elizabeth, Karl, Robert T., Factor, Daniel C., Miller, Tyler E., Nevin, Zachary S., Kantor, Christopher, Sargent, Alex, Quick, Kevin L., Schlatzer, Daniela M., Tang, Hong, Papoian, Ruben, Brimacombe, Kyle R., Shen, Min, Boxer, Matthew B., Jadhav, Ajit, Robinson, Andrew P., Podojil, Joseph R., Miller, Stephen D., Miller, Robert H., Tesar, Paul J.
Publicado 2015

Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays

por Urban, Daniel J., Martinez, Natalia J., Davis, Mindy I., Brimacombe, Kyle R., Cheff, Dorian M., Lee, Tobie D., Henderson, Mark J., Titus, Steven A., Pragani, Rajan, Rohde, Jason M., Liu, Li, Fang, Yuhong, Karavadhi, Surendra, Shah, Pranav, Lee, Olivia W., Wang, Amy, McIver, Andrew, Zheng, Hongchao, Wang, Xiaodong, Xu, Xin, Jadhav, Ajit, Simeonov, Anton, Shen, Min, Boxer, Matthew B., Hall, Matthew D.
Publicado 2017

A PHGDH inhibitor reveals coordination of serine synthesis and 1-carbon unit fate

por Pacold, Michael E., Brimacombe, Kyle R., Chan, Sze Ham, Rohde, Jason M., Lewis, Caroline A., Swier, Lotteke J.Y.M., Possemato, Richard, Chen, Walter W., Sullivan, Lucas B., Fiske, Brian P., Cho, Sung Won, Freinkman, Elizaveta, Birsoy, Kıvanç, Abu-Remaileh, Monther, Shaul, Yoav D., Liu, Chieh Min, Zhou, Minerva, Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M., Luengo, Alba, Wang, Amy Q., Xu, Xin, Yasgar, Adam, Liu, Li, Rai, Ganesha, Westover, Kenneth D., Vander Heiden, Matthew G., Shen, Min, Gray, Nathanael S., Boxer, Matthew B., Sabatini, David M.
Publicado 2016

An OpenData portal to share COVID-19 drug repurposing data in real time

por Brimacombe, Kyle R., Zhao, Tongan, Eastman, Richard T., Hu, Xin, Wang, Ke, Backus, Mark, Baljinnyam, Bolormaa, Chen, Catherine Z., Chen, Lu, Eicher, Tara, Ferrer, Marc, Fu, Ying, Gorshkov, Kirill, Guo, Hui, Hanson, Quinlin M., Itkin, Zina, Kales, Stephen C., Klumpp-Thomas, Carleen, Lee, Emily M., Michael, Sam, Mierzwa, Tim, Patt, Andrew, Pradhan, Manisha, Renn, Alex, Shinn, Paul, Shrimp, Jonathan H., Viraktamath, Amit, Wilson, Kelli M., Xu, Miao, Zakharov, Alexey V., Zhu, Wei, Zheng, Wei, Simeonov, Anton, Mathé, Ewy A., Lo, Donald C., Hall, Matthew D., Shen, Min
Publicado 2020

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

por Hall, Matthew D, Anderson, James M, Anderson, Annaliesa, Baker, David, Bradner, Jay, Brimacombe, Kyle R, Campbell, Elizabeth A, Corbett, Kizzmekia S, Carter, Kara, Cherry, Sara, Chiang, Lillian, Cihlar, Tomas, de Wit, Emmie, Denison, Mark, Disney, Matthew, Fletcher, Courtney V, Ford-Scheimer, Stephanie L, Götte, Matthias, Grossman, Abigail C, Hayden, Frederick G, Hazuda, Daria J, Lanteri, Charlotte A, Marston, Hilary, Mesecar, Andrew D, Moore, Stephanie, Nwankwo, Jennifer O, O’Rear, Jules, Painter, George, Singh Saikatendu, Kumar, Schiffer, Celia A, Sheahan, Timothy P, Shi, Pei-Yong, Smyth, Hugh D, Sofia, Michael J, Weetall, Marla, Weller, Sandra K, Whitley, Richard, Fauci, Anthony S, Austin, Christopher P, Collins, Francis S, Conley, Anthony J, Davis, Mindy I
Publicado 2021

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

por Anastasiou, Dimitrios, Yu, Yimin, Israelsen, William J., Jiang, Jian-kang, Boxer, Matthew B., Hong, Bum Soo, Tempel, Wolfram, Dimov, Svetoslav, Shen, Min, Jha, Abhishek, Yang, Hua, Mattaini, Katherine R., Metallo, Christian M., Fiske, Brian P., Courtney, Kevin D., Malstrom, Scott, Khan, Tahsin M., Kung, Charles, Skoumbourdis, Amanda P., Veith, Henrike, Southall, Noel, Walsh, Martin J., Brimacombe, Kyle R., Leister, William, Lunt, Sophia Y., Johnson, Zachary R., Yen, Katharine E., Kunii, Kaiko, Davidson, Shawn M., Christofk, Heather R., Austin, Christopher P., Inglese, James, Harris, Marian H., Asara, John M., Stephanopoulos, Gregory, Salituro, Francesco G., Jin, Shengfang, Dang, Lenny, Auld, Douglas S., Park, Hee-Won, Cantley, Lewis C., Thomas, Craig J., Vander Heiden, Matthew G.
Publicado 2012

Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space

por Kearney, Sara E., Zahoránszky-Kőhalmi, Gergely, Brimacombe, Kyle R., Henderson, Mark J., Lynch, Caitlin, Zhao, Tongan, Wan, Kanny K., Itkin, Zina, Dillon, Christopher, Shen, Min, Cheff, Dorian M., Lee, Tobie D., Bougie, Danielle, Cheng, Ken, Coussens, Nathan P., Dorjsuren, Dorjbal, Eastman, Richard T., Huang, Ruili, Iannotti, Michael J., Karavadhi, Surendra, Klumpp-Thomas, Carleen, Roth, Jacob S., Sakamuru, Srilatha, Sun, Wei, Titus, Steven A., Yasgar, Adam, Zhang, Ya-Qin, Zhao, Jinghua, Andrade, Rodrigo B., Brown, M. Kevin, Burns, Noah Z., Cha, Jin K., Mevers, Emily E., Clardy, Jon, Clement, Jason A., Crooks, Peter A., Cuny, Gregory D., Ganor, Jake, Moreno, Jesus, Morrill, Lucas A., Picazo, Elias, Susick, Robert B., Garg, Neil K., Goess, Brian C., Grossman, Robert B., Hughes, Chambers C., Johnston, Jeffrey N., Joullie, Madeleine M., Kinghorn, A. Douglas, Kingston, David G.I., Krische, Michael J., Kwon, Ohyun, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mohamed, Enas, Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Brown, Lauren E., Snyder, John K., Porco, John A., Rivas, Fatima, Ross, Samir A., Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Xu, Zhengren, Shen, Ben, Shi, Wei, Stephenson, Corey R.J., Verano, Alyssa L., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Vosburg, David A., Wu, Jimmy, Wuest, William M., Zakarian, Armen, Zhang, Yufeng, Ren, Tianjing, Zuo, Zhong, Inglese, James, Michael, Sam, Simeonov, Anton, Zheng, Wei, Shinn, Paul, Jadhav, Ajit, Boxer, Matthew B., Hall, Matthew D., Xia, Menghang, Guha, Rajarshi, Rohde, Jason M.
Publicado 2018