Pharmacokinetics of Oral Formulations of Gepotidacin (GSK2140944), a Triazaacenaphthylene Bacterial Type II Topoisomerase Inhibitor, in Healthy Adult and Adolescent Participants

por Barth, Aline, Hossain, Mohammad, Brimhall, Darin B., Perry, Caroline R., Tiffany, Courtney A., Xu, Sherry, Dumont, Etienne F.
Publicado 2022

551. MK-8591 Does Not Alter the Pharmacokinetics of the Oral Contraceptives Ethinyl Estradiol and Levonorgestrel

por Ankrom, Wendy, Jonathan, Daniel, Rudd, Deanne, Zhang, Sandra, Fillgrove, Kerry, Gravesande, Kezia, Matthews, Randolph, Brimhall, Darin, Stoch, Aubrey, Iwamoto, Marian
Publicado 2018

Randomised, phase I pharmacokinetic study of adalimumab biosimilar CT‐P17 (40 mg/0.4 mL) by autoinjector and prefilled syringe in healthy subjects

por Davidson, Antonia, Brimhall, Darin, Kay, Jonathan, Keystone, Edward, Lee, Sang Joon, Kim, Sung Hyun, Bae, Yun Ju, Choi, Eun Jin, Furst, Daniel E.
Publicado 2021

A phase 1, open‐label study to evaluate the drug interaction between islatravir (MK‐8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females

por Ankrom, Wendy, Jackson Rudd, Deanne, Zhang, Saijuan, Fillgrove, Kerry L., Gravesande, Kezia N., Matthews, Randolph P., Brimhall, Darin, Stoch, S. Aubrey, Iwamoto, Marian N.
Publicado 2021

Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug–drug interactions via CYP3A metabolism and transporters

por Barth, Aline, Perry, Caroline R., Shabbir, Shaila, Zamek‐Gliszczynski, Maciej J., Thomas, Sebin, Dumont, Etienne F., Brimhall, Darin B., Nguyen, Dung, Srinivasan, Meenakshi, Swift, Brandon
Publicado 2023

Pharmacokinetic, Safety, and Tolerability Evaluations of Gepotidacin (GSK2140944) in Healthy Japanese Participants

por Barth, Aline, Hossain, Mohammad, Perry, Caroline R., Gross, Annette S., Ogura, Hirofumi, Shabbir, Shaila, Thomas, Sebin, Dumont, Etienne F., Brimhall, Darin B., Srinivasan, Meenakshi, Swift, Brandon
Publicado 2022