Intrinsic differences in the mechanisms of Tie2 binding to angiopoietins exploited by directed evolution to create an Ang2-selective ligand trap

por Bate, Neil, Lodge, James, Brindle, Nicholas P.J.
Publicado 2021

The RNA binding protein hnRNP-K mediates post-transcriptional regulation of uncoupling protein-2 by angiopoietin-1

por Tahir, Tariq A., Singh, Harprit, Brindle, Nicholas P.J.
Publicado 2014

The Molecular Balance between Receptor Tyrosine Kinases Tie1 and Tie2 Is Dynamically Controlled by VEGF and TNFα and Regulates Angiopoietin Signalling

por Singh, Harprit, Hansen, Tania M., Patel, Nisha, Brindle, Nicholas P. J.
Publicado 2012

Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface

por Hansen, Tania M., Singh, Harprit, Tahir, Tariq A., Brindle, Nicholas P.J.
Publicado 2010

Directed Evolution of an Angiopoietin-2 Ligand Trap by Somatic Hypermutation and Cell Surface Display

por Brindle, Nicholas P. J., Sale, Julian E., Arakawa, Hiroshi, Buerstedde, Jean-Marie, Nuamchit, Teonchit, Sharma, Shikha, Steele, Kathryn H.
Publicado 2013

Regulation of Angiopoietin Signalling by Soluble Tie2 Ectodomain and Engineered Ligand Trap

por Alawo, Deborah O. A., Tahir, Tariq A., Fischer, Marlies, Bates, Declan G., Amirova, Svetlana R., Brindle, Nicholas P. J.
Publicado 2017

In vitro evolution predicts emerging SARS-CoV-2 mutations with high affinity for ACE2 and cross-species binding

por Bate, Neil, Savva, Christos G., Moody, Peter C. E., Brown, Edward A., Evans, Sian E., Ball, Jonathan K., Schwabe, John W. R., Sale, Julian E., Brindle, Nicholas P. J.
Publicado 2022

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

por Kopp, Petra M., Bate, Neil, Hansen, Tania M., Brindle, Nicholas P.J., Praekelt, Uta, Debrand, Emmanuel, Coleman, Stacey, Mazzeo, Daniela, Goult, Benjamin T., Gingras, Alexandre R., Pritchard, Catrin A., Critchley, David R., Monkley, Susan J.
Publicado 2010