The Inhibitory Receptor Siglec-8 Interacts With FcεRI and Globally Inhibits Intracellular Signaling in Primary Mast Cells Upon Activation

por Korver, Wouter, Wong, Alan, Gebremeskel, Simon, Negri, Gian Luca, Schanin, Julia, Chang, Katherine, Leung, John, Benet, Zachary, Luu, Thuy, Brock, Emily C., Luehrsen, Kenneth, Xu, Alan, Youngblood, Bradford A.
Publicado 2022

Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

por Schanin, Julia, Korver, Wouter, Brock, Emily C., Leung, John, Benet, Zachary, Luu, Thuy, Chang, Katherine, Xu, Alan, De Freitas, Naomi, Luehrsen, Kenneth, Brehm, Michael A., Wong, Alan, Youngblood, Bradford A.
Publicado 2022

Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis

por Walsh, Carolyn M, Hill, Rose Z, Schwendinger-Schreck, Jamie, Deguine, Jacques, Brock, Emily C, Kucirek, Natalie, Rifi, Ziad, Wei, Jessica, Gronert, Karsten, Brem, Rachel B, Barton, Gregory M, Bautista, Diana M
Publicado 2019

Discovery, Function, and Therapeutic Targeting of Siglec-8

por Youngblood, Bradford A., Leung, John, Falahati, Rustom, Williams, Jason, Schanin, Julia, Brock, Emily C., Singh, Bhupinder, Chang, Alan T., O’Sullivan, Jeremy A., Schleimer, Robert P., Tomasevic, Nenad, Bebbington, Christopher R., Bochner, Bruce S.
Publicado 2020

Mast Cell and Eosinophil Activation Are Associated With COVID-19 and TLR-Mediated Viral Inflammation: Implications for an Anti-Siglec-8 Antibody

por Gebremeskel, Simon, Schanin, Julia, Coyle, Krysta M., Butuci, Melina, Luu, Thuy, Brock, Emily C., Xu, Alan, Wong, Alan, Leung, John, Korver, Wouter, Morin, Ryan D., Schleimer, Robert P., Bochner, Bruce S., Youngblood, Bradford A.
Publicado 2021

A monoclonal antibody to Siglec-8 suppresses non-allergic airway inflammation and inhibits IgE-independent mast cell activation

por Schanin, Julia, Gebremeskel, Simon, Korver, Wouter, Falahati, Rustom, Butuci, Melina, Haw, Tatt Jhong, Nair, Prema M., Liu, Gang, Hansbro, Nicole G., Hansbro, Philip M., Evensen, Erik, Brock, Emily C., Xu, Alan, Wong, Alan, Leung, John, Bebbington, Christopher, Tomasevic, Nenad, Youngblood, Bradford A.
Publicado 2020