Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment

por Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado 2008

Genomic Variation and Pharmacokinetics in Old Age: A Quantitative Review of Age‐ vs. Genotype‐Related Differences

por Dücker, Christof M., Brockmöller, Jürgen
Publicado 2018

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3

por Gebauer, Lukas, Rafehi, Muhammad, Brockmöller, Jürgen
Publicado 2022

Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)

por Bokelmann, Kristin, Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado 2018

Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers?

por Jensen, Ole, Rafehi, Muhammad, Gebauer, Lukas, Brockmöller, Jürgen
Publicado 2021

Relationships between Inhibition, Transport and Enhanced Transport via the Organic Cation Transporter 1

por Jensen, Ole, Gebauer, Lukas, Brockmöller, Jürgen, Dücker, Christof
Publicado 2022

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine

por Meyer, Marleen Julia, Seitz, Tina, Brockmöller, Jürgen, Tzvetkov, Mladen Vassilev
Publicado 2017

Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3

por Gebauer, Lukas, Jensen, Ole, Neif, Maria, Brockmöller, Jürgen, Dücker, Christof
Publicado 2021

CYP2B6 Functional Variability in Drug Metabolism and Exposure Across Populations—Implication for Drug Safety, Dosing, and Individualized Therapy

por Langmia, Immaculate M., Just, Katja S., Yamoune, Sabrina, Brockmöller, Jürgen, Masimirembwa, Collen, Stingl, Julia C.
Publicado 2021

Atypical Substrates of the Organic Cation Transporter 1

por Redeker, Kyra-Elisa Maria, Jensen, Ole, Gebauer, Lukas, Meyer-Tönnies, Marleen Julia, Brockmöller, Jürgen
Publicado 2022

Protocol for MInimizing the Risk of Metachronous Adenomas of the CoLorectum with Green Tea Extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for...

por Stingl, Julia C, Ettrich, Thomas, Muche, Rainer, Wiedom, Martina, Brockmöller, Jürgen, Seeringer, Angela, Seufferlein, Thomas
Publicado 2011

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

por Jensen, Ole, Matthaei, Johannes, Klemp, Henry G., Meyer, Marleen J., Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado 2021

Substrates of the Human Brain Proton-Organic Cation Antiporter and Comparison with Organic Cation Transporter 1 Activities

por Doetsch, David A., Ansari, Salim, Jensen, Ole, Gebauer, Lukas, Dücker, Christof, Brockmöller, Jürgen, Sachkova, Alexandra
Publicado 2022

Population nutrikinetics of green tea extract

por Scholl, Catharina, Lepper, Anna, Lehr, Thorsten, Hanke, Nina, Schneider, Katharina Luise, Brockmöller, Jürgen, Seufferlein, Thomas, Stingl, Julia Carolin
Publicado 2018

A double-Flp-in method for stable overexpression of two genes

por Jensen, Ole, Ansari, Salim, Gebauer, Lukas, Müller, Simon F., Lowjaga, Kira A. A. T., Geyer, Joachim, Tzvetkov, Mladen V., Brockmöller, Jürgen
Publicado 2020

Amino acids in transmembrane helix 1 confer major functional differences between human and mouse orthologs of the polyspecific membrane transporter OCT1

por Meyer, Marleen J., Schreier, Pascale C.F., Basaran, Mert, Vlasova, Stefaniia, Seitz, Tina, Brockmöller, Jürgen, Zdrazil, Barbara, Tzvetkov, Mladen V.
Publicado 2022

Impact of UGT2B7 (His268Tyr )polymorphism on the outcome of adjuvant epirubicin treatment in breast cancer

por Parmar, Sumit, Stingl, Julia Carolin, Huber-Wechselberger, Ariana, Kainz, Alexander, Renner, Wilfried, Langsenlehner, Uwe, Krippl, Peter, Brockmöller, Jürgen, Haschke-Becher, Elisabeth
Publicado 2011

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

por Matthaei, Johannes, Brockmöller, Jürgen, Steimer, Werner, Pischa, Konstanze, Leucht, Stefan, Kullmann, Maria, Jensen, Ole, Ouethy, Typhaine, Tzvetkov, Mladen Vassilev, Rafehi, Muhammad
Publicado 2021

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

por Seitz, Tina, Stalmann, Robert, Dalila, Nawar, Chen, Jiayin, Pojar, Sherin, Dos Santos Pereira, Joao N., Krätzner, Ralph, Brockmöller, Jürgen, Tzvetkov, Mladen V.
Publicado 2015

Low heritability in pharmacokinetics of talinolol: a pharmacogenetic twin study on the heritability of the pharmacokinetics of talinolol, a putative probe drug of MDR1 and other me...

por Matthaei, Johannes, Tzvetkov, Mladen V., Gal, Valerie, Sachse-Seeboth, Cordula, Sehrt, Daniel, Hjelmborg, Jakob B., Hofmann, Ute, Schwab, Matthias, Kerb, Reinhold, Brockmöller, Jürgen
Publicado 2016