Reduced Secretion of YopJ by Yersinia Limits In Vivo Cell Death but Enhances Bacterial Virulence

por Brodsky, Igor E., Medzhitov, Ruslan
Publicado 2008

Cell death programs in Yersinia immunity and pathogenesis

por Philip, Naomi H., Brodsky, Igor E.
Publicado 2012

Yersinia deploys type III-secreted effectors to evade caspase-4 inflammasome activation in human cells

por Zhang, Jenna, Brodsky, Igor E., Shin, Sunny
Publicado 2023

Yersinia Type III-Secreted Effectors Evade the Caspase-4 Inflammasome in Human Cells

por Zhang, Jenna, Brodsky, Igor E., Shin, Sunny
Publicado 2023

TNF licenses macrophages to undergo rapid caspase-1, -11, and -8-mediated cell death that restricts Legionella pneumophila infection

por Pollock, Tzvi Y., Vázquez Marrero, Víctor R., Brodsky, Igor E., Shin, Sunny
Publicado 2023

Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling

por Wertman, Ronit Schwartz, Go, Christina K., Saller, Benedikt S., Groß, Olaf, Scott, Phillip, Brodsky, Igor E.
Publicado 2023

A Yersinia Effector with Enhanced Inhibitory Activity on the NF-κB Pathway Activates the NLRP3/ASC/Caspase-1 Inflammasome in Macrophages

por Zheng, Ying, Lilo, Sarit, Brodsky, Igor E., Zhang, Yue, Medzhitov, Ruslan, Marcu, Kenneth B., Bliska, James B.
Publicado 2011

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

por Brunette, Rebecca L., Young, Janet M., Whitley, Deborah G., Brodsky, Igor E., Malik, Harmit S., Stetson, Daniel B.
Publicado 2012

Increased autophagic sequestration in adaptor protein-3 deficient dendritic cells limits inflammasome activity and impairs antibacterial immunity

por Mantegazza, Adriana R., Wynosky-Dolfi, Meghan A., Casson, Cierra N., Lefkovith, Ariel J., Shin, Sunny, Brodsky, Igor E., Marks, Michael S.
Publicado 2017

IQGAP1 Is Important for Activation of Caspase-1 in Macrophages and Is Targeted by Yersinia pestis Type III Effector YopM

por Chung, Lawton K., Philip, Naomi H., Schmidt, Valentina A., Koller, Antonius, Strowig, Till, Flavell, Richard A., Brodsky, Igor E., Bliska, James B.
Publicado 2014

TLR priming licenses NAIP inflammasome activation by immunoevasive ligands

por Grayczyk, James P., Egan, Marisa S., Liu, Luying, Aunins, Emily, Wynosky-Dolfi, Meghan A., Canna, Scott, Minn, Andy J., Shin, Sunny, Brodsky, Igor E.
Publicado 2023

CD8(+) T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production

por Novais, Fernanda O., Carvalho, Augusto M., Clark, Megan L., Carvalho, Lucas P., Beiting, Daniel P., Brodsky, Igor E., Carvalho, Edgar M., Scott, Phillip
Publicado 2017

Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication

por Naseer, Nawar, Egan, Marisa S., Reyes Ruiz, Valeria M., Scott, William P., Hunter, Emma N., Demissie, Tabitha, Rauch, Isabella, Brodsky, Igor E., Shin, Sunny
Publicado 2022

Differential Induction of TLR3-Dependent Innate Immune Signaling by Closely Related Parasite Species

por Beiting, Daniel P., Peixoto, Lucia, Akopyants, Natalia S., Beverley, Stephen M., Wherry, E. John, Christian, David A., Hunter, Christopher A., Brodsky, Igor E., Roos, David S.
Publicado 2014

TLR signaling augments macrophage bactericidal activity through mitochondrial ROS

por West, A. Phillip, Brodsky, Igor E., Rahner, Christoph, Woo, Dong Kyun, Erdjument-Bromage, Hediye, Tempst, Paul, Walsh, Matthew C., Choi, Yongwon, Shadel, Gerald S., Ghosh, Sankar
Publicado 2011

Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD

por Zwack, Erin E., Snyder, Annelise G., Wynosky-Dolfi, Meghan A., Ruthel, Gordon, Philip, Naomi H., Marketon, Melanie M., Francis, Matthew S., Bliska, James B., Brodsky, Igor E.
Publicado 2015

BCR-Induced Ca(2+) Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

por Berry, Corbett T., Liu, Xiaohong, Myles, Arpita, Nandi, Satabdi, Chen, Youhai H., Hershberg, Uri, Brodsky, Igor E., Cancro, Michael P., Lengner, Christopher J., May, Michael J., Freedman, Bruce D.
Publicado 2020

Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages

por Egan, Marisa S., O’Rourke, Emily A., Mageswaran, Shrawan Kumar, Zuo, Biao, Martynyuk, Inna, Demissie, Tabitha, Hunter, Emma N., Bass, Antonia R., Chang, Yi-Wei, Brodsky, Igor E., Shin, Sunny
Publicado 2023

Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol

por Casson, Cierra N., Copenhaver, Alan M., Zwack, Erin E., Nguyen, Hieu T., Strowig, Till, Javdan, Bahar, Bradley, William P., Fung, Thomas C., Flavell, Richard A., Brodsky, Igor E., Shin, Sunny
Publicado 2013

The intestinal parasite Cryptosporidium is controlled by an enterocyte intrinsic inflammasome that depends on NLRP6

por Sateriale, Adam, Gullicksrud, Jodi A., Engiles, Julie B., McLeod, Briana I., Kugler, Emily M., Henao-Mejia, Jorge, Zhou, Ting, Ring, Aaron M., Brodsky, Igor E., Hunter, Christopher A., Striepen, Boris
Publicado 2021