An EMR-Based Approach to Determine Frequency, Prescribing Pattern, and Characteristics of Patients Receiving Drugs with Pharmacogenomic Guidelines

por MacKinnon, George E., Mills, Megan, Stoddard, Alexander, Urrutia, Raul A., Broeckel, Ulrich
Publicado 2023

Comprehensive evaluation of AmpliSeq transcriptome, a novel targeted whole transcriptome RNA sequencing methodology for global gene expression analysis

por Li, Wenli, Turner, Amy, Aggarwal, Praful, Matter, Andrea, Storvick, Erin, Arnett, Donna K., Broeckel, Ulrich
Publicado 2015

Human IL12RB1 expression is allele-biased and produces a novel IL12 response regulator

por Reeme, Allison E., Claeys, Tiffany A., Aggarwal, Praful, Turner, Amy J., Routes, John M., Broeckel, Ulrich, Robinson, Richard T.
Publicado 2018

Characterization of complex structural variation in the CYP2D6-CYP2D7-CYP2D8 gene loci using single-molecule long-read sequencing

por Turner, Amy J., Derezinski, Ashley D., Gaedigk, Andrea, Berres, Mark E., Gregornik, David B., Brown, Keith, Broeckel, Ulrich, Scharer, Gunter
Publicado 2023

Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: The HyperGEN Study

por Arnett, Donna K, Li, Na, Tang, Weihong, Rao, Dabeeru C, Devereux, Richard B, Claas, Steven A, Kraemer, Rachel, Broeckel, Ulrich
Publicado 2009

RNA Expression Profiling of Human iPSC-Derived Cardiomyocytes in a Cardiac Hypertrophy Model

por Aggarwal, Praful, Turner, Amy, Matter, Andrea, Kattman, Steven J., Stoddard, Alexander, Lorier, Rachel, Swanson, Bradley J., Arnett, Donna K., Broeckel, Ulrich
Publicado 2014

Characterization of Novel CYP2D6 Alleles across Sub-Saharan African Populations

por Wang, Wendy Y., Twesigomwe, David, Nofziger, Charity, Turner, Amy J., Helmecke, Lena-Sophie, Broeckel, Ulrich, Derezinski, Ashley D., Hazelhurst, Scott, Gaedigk, Andrea
Publicado 2022

Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study

por Wineinger, Nathan E, Patki, Amit, Meyers, Kristin J, Broeckel, Ulrich, Gu, Charles C, Rao, DC, Devereux, Richard B, Arnett, Donna K, Tiwari, Hemant K
Publicado 2011

Copy number variations associated with obesity related traits in African Americans: a joint analysis between GENOA and HyperGEN

por Zhao, Wei, Wineinger, Nathan E., Tiwari, Hemant K., Mosley, Thomas H., Broeckel, Ulrich, Arnett, Donna K., Kardia, Sharon L. R., Kabagambe, Edmond K., Sun, Yan V.
Publicado 2012

PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development

por Yu, Mei, Chen, Yuhong, Zeng, Hu, Zheng, Yongwei, Fu, Guoping, Zhu, Wen, Broeckel, Ulrich, Aggarwal, Praful, Turner, Amy, Neale, Geoffrey, Guy, Cliff, Zhu, Nan, Chi, Hongbo, Wen, Renren, Wang, Demin
Publicado 2017

Concordance between glucose-6-phosphate dehydrogenase (G6PD) genotype and phenotype and rasburicase use in patients with hematologic malignancies

por Robinson, Katherine M., Yang, Wenjian, Haidar, Cyrine E., Hankins, Jane S., Jay, Dennis W., Kornegay, Nancy, Rubnitz, Jeffrey E., Broeckel, Ulrich, Cheng, Cheng, Pui, Ching-Hon, Jeha, Sima, Relling, Mary V.
Publicado 2018

PCSK9 variation and association with blood pressure in African Americans: preliminary findings from the HyperGEN and REGARDS studies

por Tran, Ngan T., Aslibekyan, Stella, Tiwari, Hemant K., Zhi, Degui, Sung, Yun Ju, Hunt, Steven C., Rao, DC, Broeckel, Ulrich, Judd, Suzanne E., Muntner, Paul, Kent, Shia T., Arnett, Donna K., Irvin, Marguerite R.
Publicado 2015

BMP4 loss-of-function mutations in developmental eye disorders including SHORT syndrome

por Reis, Linda M., Tyler, Rebecca C., Schilter, Kala F., Abdul-Rahman, Omar, Innis, Jeffrey W., Kozel, Beth A., Schneider, Adele S., Bardakjian, Tanya M., Lose, Edward J., Martin, Donna M., Broeckel, Ulrich, Semina, Elena V.
Publicado 2011

A comprehensive analysis of adiponectin QTLs using SNP association, SNP cis-effects on peripheral blood gene expression and gene expression correlation identified novel metabolic s...

por Zhang, Yi, Kent, Jack W, Olivier, Michael, Ali, Omar, Cerjak, Diana, Broeckel, Ulrich, Abdou, Reham M, Dyer, Thomas D, Comuzzie, Anthony, Curran, Joanne E, Carless, Melanie A, Rainwater, David L, Göring, Harald H H, Blangero, John, Kissebah, Ahmed H
Publicado 2013

Development and use of active clinical decision support for preemptive pharmacogenomics

por Bell, Gillian C, Crews, Kristine R, Wilkinson, Mark R, Haidar, Cyrine E, Hicks, J Kevin, Baker, Donald K, Kornegay, Nancy M, Yang, Wenjian, Cross, Shane J, Howard, Scott C, Freimuth, Robert R, Evans, William E, Broeckel, Ulrich, Relling, Mary V, Hoffman, James M
Publicado 2014

Whole-Exome Sequencing and hiPSC Cardiomyocyte Models Identify MYRIP, TRAPPC11, and SLC27A6 of Potential Importance to Left Ventricular Hypertrophy in an African Ancestry Populatio...

por Irvin, Marguerite R., Aggarwal, Praful, Claas, Steven A., de las Fuentes, Lisa, Do, Anh N., Gu, C. Charles, Matter, Andrea, Olson, Benjamin S., Patki, Amit, Schwander, Karen, Smith, Joshua D., Srinivasasainagendra, Vinodh, Tiwari, Hemant K., Turner, Amy J., Nickerson, Deborah A., Rao, Dabeeru C., Broeckel, Ulrich, Arnett, Donna K.
Publicado 2021

Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man

por Luchtefeld, Maren, Schunkert, Heribert, Stoll, Monika, Selle, Tina, Lorier, Rachel, Grote, Karsten, Sagebiel, Christian, Jagavelu, Kumaravelu, Tietge, Uwe J.F., Assmus, Ulrike, Streetz, Konrad, Hengstenberg, Christian, Fischer, Marcus, Mayer, Björn, Maresso, Karen, El Mokhtari, Nour Eddine, Schreiber, Stefan, Müller, Werner, Bavendiek, Udo, Grothusen, Christina, Drexler, Helmut, Trautwein, Christian, Broeckel, Ulrich, Schieffer, Bernhard
Publicado 2007

Thymic regulatory T cells arise via two distinct developmental programs

por Owen, David L., Mahmud, Shawn A., Sjaastad, Louisa E., Williams, Jason B., Spanier, Justin A., Simeonov, Dimitre R., Ruscher, Roland, Huang, Weishan, Proekt, Irina, Miller, Corey N., Hekim, Can, Jeschke, Jonathan C., Aggarwal, Praful, Broeckel, Ulrich, LaRue, Rebecca S., Henzler, Christine M., Alegre, Maria-Luisa, Anderson, Mark S., August, Avery, Marson, Alexander, Zheng, Ye, Williams, Calvin B., Farrar, Michael A.
Publicado 2019

Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program

por Kanchan, Kanika, Iyer, Kruthika, Yanek, Lisa R, Carcamo-Orive, Ivan, Taub, Margaret A, Malley, Claire, Baldwin, Kristin, Becker, Lewis C, Broeckel, Ulrich, Cheng, Linzhao, Cowan, Chad, D'Antonio, Matteo, Frazer, Kelly A, Quertermous, Thomas, Mostoslavsky, Gustavo, Murphy, George, Rabinovitch, Marlene, Rader, Daniel J, Steinberg, Martin H, Topol, Eric, Yang, Wenli, Knowles, Joshua W, Jaquish, Cashell E, Ruczinski, Ingo, Mathias, Rasika A
Publicado 2020

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

por Mangino, Massimo, Hwang, Shih-Jen, Spector, Timothy D., Hunt, Steven C., Kimura, Masayuki, Fitzpatrick, Annette L., Christiansen, Lene, Petersen, Inge, Elbers, Clara C., Harris, Tamara, Chen, Wei, Srinivasan, Sathanur R., Kark, Jeremy D., Benetos, Athanase, El Shamieh, Said, Visvikis-Siest, Sophie, Christensen, Kaare, Berenson, Gerald S., Valdes, Ana M., Viñuela, Ana, Garcia, Melissa, Arnett, Donna K., Broeckel, Ulrich, Province, Michael A., Pankow, James S., Kammerer, Candace, Liu, Yongmei, Nalls, Michael, Tishkoff, Sarah, Thomas, Fridtjof, Ziv, Elad, Psaty, Bruce M., Bis, Joshua C., Rotter, Jerome I., Taylor, Kent D., Smith, Erin, Schork, Nicholas J., Levy, Daniel, Aviv, Abraham
Publicado 2012