The Intrinsic Electrostatic Potential and the Intermediate Ring of Charge in the Acetylcholine Receptor Channel

por Wilson, Gary G., Pascual, Juan M., Brooijmans, Natasja, Murray, Diana, Karlin, Arthur
Publicado 2000

Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science

por Stuart, Darrin D., Guzman-Perez, Angel, Brooijmans, Natasja, Jackson, Erica L., Kryukov, Gregory V., Friedman, Adam A., Hoos, Axel
Publicado 2023

Inside the Mind of a Medicinal Chemist: The Role of Human Bias in Compound Prioritization during Drug Discovery

por Kutchukian, Peter S., Vasilyeva, Nadya Y., Xu, Jordan, Lindvall, Mika K., Dillon, Michael P., Glick, Meir, Coley, John D., Brooijmans, Natasja
Publicado 2012

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts

por Buckbinder, Leonard, St. Jean, David J., Tieu, Trang, Ladd, Brendon, Hilbert, Brendan, Wang, Weixue, Alltucker, Jacob T., Manimala, Samantha, Kryukov, Gregory V., Brooijmans, Natasja, Dowdell, Gregory, Jonsson, Philip, Huff, Michael, Guzman-Perez, Angel, Jackson, Erica L., Goncalves, Marcus D., Stuart, Darrin D.
Publicado 2023

Discovery of BLU-945, a Reversible, Potent, and Wild-Type-Sparing Next-Generation EGFR Mutant Inhibitor for Treatment-Resistant Non-Small-Cell Lung Cancer

por Eno, Meredith S., Brubaker, Jason D., Campbell, John E., De Savi, Chris, Guzi, Timothy J., Williams, Brett D., Wilson, Douglas, Wilson, Kevin, Brooijmans, Natasja, Kim, Joseph, Özen, Ayşegül, Perola, Emanuele, Hsieh, John, Brown, Victoria, Fetalvero, Kristina, Garner, Andrew, Zhang, Zhuo, Stevison, Faith, Woessner, Rich, Singh, Jatinder, Timsit, Yoav, Kinkema, Caitlin, Medendorp, Clare, Lee, Christopher, Albayya, Faris, Zalutskaya, Alena, Schalm, Stefanie, Dineen, Thomas A.
Publicado 2022