Pros and cons of a prion-like pathogenesis in Parkinson's disease

por Hilker, Ruediger, Brotchie, Jonathan M, Chapman, Joab
Publicado 2011

Monoamine Reuptake Inhibitors in Parkinson's Disease

por Huot, Philippe, Fox, Susan H., Brotchie, Jonathan M.
Publicado 2015

Towards a Non-Human Primate Model of Alpha-Synucleinopathy for Development of Therapeutics for Parkinson’s Disease: Optimization of AAV1/2 Delivery Parameters to Drive Sustained Ex...

por Koprich, James B., Johnston, Tom H., Reyes, Gabriela, Omana, Vanessa, Brotchie, Jonathan M.
Publicado 2016

Exosome markers of LRRK2 kinase inhibition

por Wang, Shijie, Kelly, Kaela, Brotchie, Jonathan M., Koprich, James B., West, Andrew B.
Publicado 2020

Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite...

por Koprich, James B, Johnston, Tom H, Reyes, M Gabriela, Sun, Xuan, Brotchie, Jonathan M
Publicado 2010

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson’s Disease

por Schneider, Jay S., Aras, Radha, Williams, Courtney K., Koprich, James B., Brotchie, Jonathan M., Singh, Vikrant
Publicado 2019

Progressive Neurodegeneration or Endogenous Compensation in an Animal Model of Parkinson's Disease Produced by Decreasing Doses of Alpha-Synuclein

por Koprich, James B., Johnston, Tom H., Huot, Philippe, Reyes, M. Gabriela, Espinosa, Maria, Brotchie, Jonathan M.
Publicado 2011

Subthalamic nucleus deep brain stimulation is neuroprotective in the A53T α‐synuclein Parkinson's disease rat model

por Musacchio, Thomas, Rebenstorff, Maike, Fluri, Felix, Brotchie, Jonathan M., Volkmann, Jens, Koprich, James B., Ip, Chi Wang
Publicado 2017

Inflammasome inhibition protects dopaminergic neurons from α-synuclein pathology in a model of progressive Parkinson’s disease

por Grotemeyer, Alexander, Fischer, Judith F., Koprich, James B., Brotchie, Jonathan M., Blum, Robert, Volkmann, Jens, Ip, Chi Wang
Publicado 2023

The Promise and Challenges of Developing miRNA-Based Therapeutics for Parkinson’s Disease

por Titze-de-Almeida, Simoneide S., Soto-Sánchez, Cristina, Fernandez, Eduardo, Koprich, James B., Brotchie, Jonathan M., Titze-de-Almeida, Ricardo
Publicado 2020

Toward in vivo proof of binding of (18)F-labeled inhibitor [(18)F]TRACK to peripheral tropomyosin receptor kinases

por Wuest, Melinda, Bailey, Justin J., Dufour, Jennifer, Glubrecht, Darryl, Omana, Vanessa, Johnston, Tom H., Brotchie, Jonathan M., Schirrmacher, Ralf
Publicado 2022

The Monoamine Re-Uptake Inhibitor UWA-101 Improves Motor Fluctuations in the MPTP-Lesioned Common Marmoset

por Huot, Philippe, Johnston, Tom H., Gandy, Michael N., Reyes, M. Gabriela, Fox, Susan H., Piggott, Matthew J., Brotchie, Jonathan M
Publicado 2012

Non-steric-zipper models for pathogenic α-synuclein conformers

por Schuman, Brock, Won, Amy, Brand-Arzamendi, Koroboshka, Koprich, James B., Wen, Xiao-Yan, Howson, Patrick A., Brotchie, Jonathan M., Yip, Christopher M.
Publicado 2018

AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new m...

por Ip, Chi Wang, Klaus, Laura-Christin, Karikari, Akua A., Visanji, Naomi P., Brotchie, Jonathan M., Lang, Anthony E., Volkmann, Jens, Koprich, James B.
Publicado 2017

Expansion of regulatory T cells by CD28 superagonistic antibodies attenuates neurodegeneration in A53T-α-synuclein Parkinson’s disease mice

por Badr, Mohammad, McFleder, Rhonda L., Wu, Jingjing, Knorr, Susanne, Koprich, James B., Hünig, Thomas, Brotchie, Jonathan M., Volkmann, Jens, Lutz, Manfred B., Ip, Chi Wang
Publicado 2022

α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms

por Chiu, Wei-Hua, Kovacheva, Lora, Musgrove, Ruth E., Arien-Zakay, Hadar, Koprich, James B., Brotchie, Jonathan M., Yaka, Rami, Ben-Zvi, Danny, Hanani, Menachem, Roeper, Jochen, Goldberg, Joshua A.
Publicado 2021

Alternating Hemiplegia of Childhood-Related Neural and Behavioural Phenotypes in Na(+),K(+)-ATPase α3 Missense Mutant Mice

por Kirshenbaum, Greer S., Dawson, Neil, Mullins, Jonathan G. L., Johnston, Tom H., Drinkhill, Mark J., Edwards, Ian J., Fox, Susan H., Pratt, Judith A., Brotchie, Jonathan M., Roder, John C., Clapcote, Steven J.
Publicado 2013

Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury

por Ip, Chi Wang, Isaias, Ioannis U., Kusche-Tekin, Burak B., Klein, Dennis, Groh, Janos, O’Leary, Aet, Knorr, Susanne, Higuchi, Takahiro, Koprich, James B., Brotchie, Jonathan M., Toyka, Klaus V., Reif, Andreas, Volkmann, Jens
Publicado 2016

Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein

por McKinnon, Chris, De Snoo, Mitchell L., Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G., O’Hara, Darren M., Brotchie, Jonathan M., Koprich, James B., Lozano, Andres M., Kalia, Lorraine V., Kalia, Suneil K.
Publicado 2020

Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease

por Matschke, Lina A., Komadowski, Marlene A., Stöhr, Annette, Lee, Bolam, Henrich, Martin T., Griesbach, Markus, Rinné, Susanne, Geibl, Fanni F., Chiu, Wei-Hua, Koprich, James B., Brotchie, Jonathan M., Kiper, Aytug K., Dolga, Amalia M., Oertel, Wolfgang H., Decher, Niels
Publicado 2022