Discovery of Ligand-Efficient Scaffolds for the Design of Novel Trichomonas vaginalis Uridine Nucleoside Ribohydrolase Inhibitors Using Fragment Screening

por Auletta, Shannon, Caravan, Wagma, Persaud, Julia K., Thuilot, Samantha F., Brown, Dean G., Parkin, David W., Stockman, Brian J.
Publicado 2019

Cooperative bi-exponential decay of dye emission coupled via plasmons

por Lyvers, David P., Moazzezi, Mojtaba, de Silva, Vashista C., Brown, Dean P., Urbas, Augustine M., Rostovtsev, Yuri V., Drachev, Vladimir P.
Publicado 2018

Prolonged tau clearance and stress vulnerability rescue by pharmacological activation of autophagy in tauopathy neurons

por Silva, M. Catarina, Nandi, Ghata A., Tentarelli, Sharon, Gurrell, Ian K., Jamier, Tanguy, Lucente, Diane, Dickerson, Bradford C., Brown, Dean G., Brandon, Nicholas J., Haggarty, Stephen J.
Publicado 2020

Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition

por Brito, Hugo, Marques, Vanda, Afonso, Marta B., Brown, Dean G., Börjesson, Ulf, Selmi, Nidhal, Smith, David M., Roberts, Ieuan O., Fitzek, Martina, Aniceto, Natália, Guedes, Rita C., Moreira, Rui, Rodrigues, Cecília M. P.
Publicado 2020

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition

por Kennedy, Amanda J., Sundström, Linda, Geschwindner, Stefan, Poon, Eunice K. Y., Jiang, Yuhong, Chen, Rongfeng, Cooke, Rob, Johnstone, Shawn, Madin, Andrew, Lim, Junxian, Liu, Qingqi, Lohman, Rink-Jan, Nordqvist, Anneli, Fridén-Saxin, Maria, Yang, Wenzhen, Brown, Dean G., Fairlie, David P., Dekker, Niek
Publicado 2020

Axl receptor tyrosine kinase is a regulator of apolipoprotein E

por Zhao, Wenchen, Fan, Jianjia, Kulic, Iva, Koh, Cheryl, Clark, Amanda, Meuller, Johan, Engkvist, Ola, Barichievy, Samantha, Raynoschek, Carina, Hicks, Ryan, Maresca, Marcello, Wang, Qi, Brown, Dean G., Lok, Alvin, Parro, Cameron, Robert, Jerome, Chou, Hsien-Ya, Zuhl, Andrea M., Wood, Michael W., Brandon, Nicholas J., Wellington, Cheryl L.
Publicado 2020