Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

por Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.
Publicado 2021

Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

por Palacios-Filardo, Jon, Udakis, Matt, Brown, Giles A., Tehan, Benjamin G., Congreve, Miles S., Nathan, Pradeep J., Brown, Alastair J. H., Mellor, Jack R.
Publicado 2021

Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A(2A) Receptor crystals

por Rucktooa, Prakash, Cheng, Robert K. Y., Segala, Elena, Geng, Tian, Errey, James C., Brown, Giles A., Cooke, Robert M., Marshall, Fiona H., Doré, Andrew S.
Publicado 2018

Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M(1) receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending...

por Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Doll, Robert Jan, Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Publicado 2021

Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M(1)‐acetylcholine receptor agonist: A randomized cross‐over trial

por Bakker, Charlotte, Prins, Samantha, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Stevens, Jasper, Cross, David M., Tasker, Tim, Nathan, Pradeep J., Groeneveld, Geert Jan
Publicado 2021

First‐in‐man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M(1)‐receptor partial agonist for the treatment of dementias...

por Bakker, Charlotte, Tasker, Tim, Liptrot, Jan, Hart, Ellen P., Klaassen, Erica S., Prins, Samantha, van der Doef, Thalia F., Brown, Giles A., Brown, Alastair, Congreve, Miles, Weir, Malcolm, Marshall, Fiona H., Cross, David M., Groeneveld, Geert Jan, Nathan, Pradeep J.
Publicado 2021

Small molecule AZD4635 inhibitor of A(2A)R signaling rescues immune cell function including CD103(+) dendritic cells enhancing anti-tumor immunity

por Borodovsky, Alexandra, Barbon, Christine M, Wang, Yanjun, Ye, Minwei, Prickett, Laura, Chandra, Dinesh, Shaw, Joseph, Deng, Nanhua, Sachsenmeier, Kris, Clarke, James D, Linghu, Bolan, Brown, Giles A, Brown, James, Congreve, Miles, Cheng, Robert KY, Dore, Andrew S, Hurrell, Edward, Shao, Wenlin, Woessner, Richard, Reimer, Corinne, Drew, Lisa, Fawell, Stephen, Schuller, Alwin G, Mele, Deanna A
Publicado 2020