Development and progression of cancer cachexia: Perspectives from bench to bedside

por Lim, Seongkyun, Brown, Jacob L., Washington, Tyrone A., Greene, Nicholas P.
Publicado 2020

The Akt/mTOR pathway: Data comparing young and aged mice with leucine supplementation at the onset of skeletal muscle regeneration

por Perry, Richard A., Brown, Lemuel A., Lee, David E., Brown, Jacob L., Baum, Jamie I., Greene, Nicholas P., Washington, Tyrone A.
Publicado 2016

Mitochondrial Function and Protein Turnover in the Diaphragm are Altered in LLC Tumor Model of Cancer Cachexia

por Rosa-Caldwell, Megan E., Benson, Conner A., Lee, David E., Brown, Jacob L., Washington, Tyrone A., Greene, Nicholas P., Wiggs, Michael P.
Publicado 2020

Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice

por Greene, Nicholas P, Lee, David E, Brown, Jacob L, Rosa, Megan E, Brown, Lemuel A, Perry, Richard A, Henry, Jordyn N, Washington, Tyrone A
Publicado 2015

Lipid hydroperoxides and oxylipins are mediators of denervation induced muscle atrophy

por Brown, Jacob L., Peelor, Fredrick F., Georgescu, Constantin, Wren, Jonathan D., Kinter, Michael, Tyrrell, Victoria J., O'Donnell, Valerie B., Miller, Benjamin F., Van Remmen, Holly
Publicado 2022

Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration

por Washington, Tyrone A., Haynie, Wesley S., Schrems, Eleanor R., Perry, Richard A., Brown, Lemuel A., Williams, Breanna M., Rosa-Caldwell, Megan E., Lee, David E., Brown, Jacob L.
Publicado 2022

Mitochondrial aberrations during the progression of disuse atrophy differentially affect male and female mice

por Rosa‐Caldwell, Megan E., Lim, Seongkyun, Haynie, Wesley S., Brown, Jacob L., Lee, David E., Dunlap, Kirsten R., Jansen, Lisa T., Washington, Tyrone A., Wiggs, Michael P., Greene, Nicholas P.
Publicado 2021

PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice

por Morena da Silva, Francielly, Rosa-Caldwell, Megan E., Schrems, Eleanor R., Martinez, Lauren, Amos, Madeline G., Lim, Seongkyun, Cabrera, Ana Regina, Brown, Jacob L., Washington, Tyrone A., Greene, Nicholas P.
Publicado 2022

Targeting cPLA(2) derived lipid hydroperoxides as a potential intervention for sarcopenia

por Pharaoh, Gavin, Brown, Jacob L., Sataranatarajan, Kavithalakshmi, Kneis, Parker, Bian, Jan, Ranjit, Rojina, Hadad, Niran, Georgescu, Constantin, Rabinovitch, Peter, Ran, Qitao, Wren, Jonathan D., Freeman, Willard, Kinter, Michael, Richardson, Arlan, Van Remmen, Holly
Publicado 2020

Female mice may have exacerbated catabolic signalling response compared to male mice during development and progression of disuse atrophy

por Rosa‐Caldwell, Megan E., Lim, Seongkyun, Haynie, Wesley A., Brown, Jacob L., Deaver, John William, Morena Da Silva, Francielly, Jansen, Lisa T., Lee, David E., Wiggs, Michael P., Washington, Tyrone A., Greene, Nicholas P.
Publicado 2021

Protein imbalance in the development of skeletal muscle wasting in tumour‐bearing mice

por Brown, Jacob L., Lee, David E., Rosa‐Caldwell, Megan E., Brown, Lemuel A., Perry, Richard A., Haynie, Wesley S., Huseman, Kendra, Sataranatarajan, Kavithalakshmi, Van Remmen, Holly, Washington, Tyrone A., Wiggs, Michael P., Greene, Nicholas P.
Publicado 2018

Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma

por Thadathil, Nidheesh, Selvarani, Ramasamy, Mohammed, Sabira, Nicklas, Evan H., Tran, Albert L., Kamal, Maria, Luo, Wenyi, Brown, Jacob L., Lawrence, Marcus M., Borowik, Agnieszka K., Miller, Benjamin F., Van Remmen, Holly, Richardson, Arlan, Deepa, Sathyaseelan S.
Publicado 2022

Mitochondrial degeneration precedes the development of muscle atrophy in progression of cancer cachexia in tumour‐bearing mice

por Brown, Jacob L., Rosa‐Caldwell, Megan E., Lee, David E., Blackwell, Thomas A., Brown, Lemuel A., Perry, Richard A., Haynie, Wesley S., Hardee, Justin P., Carson, James A., Wiggs, Michael P., Washington, Tyrone A., Greene, Nicholas P.
Publicado 2017

Neuron‐specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice

por Bhaskaran, Shylesh, Pollock, Natalie, C. Macpherson, Peter, Ahn, Bumsoo, Piekarz, Katarzyna M., Staunton, Caroline A., Brown, Jacob L., Qaisar, Rizwan, Vasilaki, Aphrodite, Richardson, Arlan, McArdle, Anne, Jackson, Malcolm J., Brooks, Susan V., Van Remmen, Holly
Publicado 2020

Cancer cachexia in a mouse model of oxidative stress

por Brown, Jacob L., Lawrence, Marcus M., Ahn, Bumsoo, Kneis, Parker, Piekarz, Katarzyna M., Qaisar, Rizwan, Ranjit, Rojina, Bian, Jan, Pharaoh, Gavin, Brown, Chase, Peelor, Fredrick F., Kinter, Michael T., Miller, Benjamin F., Richardson, Arlan, Van Remmen, Holly
Publicado 2020

Neuronal deletion of MnSOD in mice leads to demyelination, inflammation and progressive paralysis that mimics phenotypes associated with progressive multiple sclerosis

por Bhaskaran, Shylesh, Kumar, Gaurav, Thadathil, Nidheesh, Piekarz, Katarzyna M., Mohammed, Sabira, Lopez, Sergio Dominguez, Qaisar, Rizwan, Walton, Dorothy, Brown, Jacob L., Murphy, Ashley, Smith, Nataliya, Saunders, Debra, Beckstead, Michael J., Plafker, Scott, Lewis, Tommy L., Towner, Rheal, Deepa, Sathyaseelan S., Richardson, Arlan, Axtell, Robert C., Van Remmen, Holly
Publicado 2022