Open access chemical probes for epigenetic targets

por Brown, Peter J, Müller, Susanne
Publicado 2015

Teaching Health as a Human Right in the Undergraduate Context: Challenges and Opportunities

por Salhi, Bisan A., Brown, Peter J.
Publicado 2019

Chemical probes targeting epigenetic proteins: Applications beyond oncology

por Ackloo, Suzanne, Brown, Peter J., Müller, Susanne
Publicado 2017

Hyperplastic and fibrosing gastropathy resembling Ménétrier disease in a cat

por Barker, Emi N, Holdsworth, Andrew S, Hibbert, Angie, Brown, Peter J, Hayward, Nicolette J
Publicado 2019

High-latitude ocean ventilation and its role in Earth's climate transitions

por Naveira Garabato, Alberto C., MacGilchrist, Graeme A. , Brown, Peter J., Evans, D. Gwyn, Meijers, Andrew J. S., Zika, Jan D.
Publicado 2017

Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

por Wu, Hong, Zeng, Hong, Dong, Aiping, Li, Fengling, He, Hao, Senisterra, Guillermo, Seitova, Alma, Duan, Shili, Brown, Peter J., Vedadi, Masoud, Arrowsmith, Cheryl H., Schapira, Matthieu
Publicado 2013

SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis

por Elkouris, Maximilianos, Kontaki, Haroula, Stavropoulos, Athanasios, Antonoglou, Anastasia, Nikolaou, Kostas C., Samiotaki, Martina, Szantai, Eszter, Saviolaki, Dimitra, Brown, Peter J., Sideras, Paschalis, Panayotou, George, Talianidis, Iannis
Publicado 2016

Reframing the carbon cycle of the subpolar Southern Ocean

por MacGilchrist, Graeme A., Naveira Garabato, Alberto C., Brown, Peter J., Jullion, Loïc, Bacon, Sheldon, Bakker, Dorothee C. E., Hoppema, Mario, Meredith, Michael P., Torres-Valdés, Sinhué
Publicado 2019

Conformational dynamics of the TTD–PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability

por Houliston, R. Scott, Lemak, Alexander, Iqbal, Aman, Ivanochko, Danton, Duan, Shili, Kaustov, Lilia, Ong, Michelle S., Fan, Lixin, Senisterra, Guillermo, Brown, Peter J., Wang, Yun-Xing, Arrowsmith, Cheryl H.
Publicado 2017

Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential t...

por Agarwal, Prasoon, Alzrigat, Mohammad, Párraga, Alba Atienza, Enroth, Stefan, Singh, Umashankar, Ungerstedt, Johanna, Österborg, Anders, Brown, Peter J., Ma, Anqi, Jin, Jian, Nilsson, Kenneth, Öberg, Fredrik, Kalushkova, Antonia, Jernberg-Wiklund, Helena
Publicado 2016

Discovery of selective activators of PRC2 mutant EED-I363M

por Suh, Junghyun L., Barnash, Kimberly D., Abramyan, Tigran M., Li, Fengling, The, Juliana, Engelberg, Isabelle A., Vedadi, Masoud, Brown, Peter J., Kireev, Dmitri B., Arrowsmith, Cheryl H., James, Lindsey I., Frye, Stephen V.
Publicado 2019

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

por Ma, Anqi, Yu, Wenyu, Li, Fengling, Bleich, Rachel M., Herold, J. Martin, Butler, Kyle V., Norris, Jacqueline L., Korboukh, Victoria, Tripathy, Ashutosh, Janzen, William P., Arrowsmith, Cheryl H., Frye, Stephen V., Vedadi, Masoud, Brown, Peter J., Jin, Jian
Publicado 2014

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

por Dahlin, Jayme L., Nelson, Kathryn M., Strasser, Jessica M., Barsyte-Lovejoy, Dalia, Szewczyk, Magdalena M., Organ, Shawna, Cuellar, Matthew, Singh, Gurpreet, Shrimp, Jonathan H., Nguyen, Nghi, Meier, Jordan L., Arrowsmith, Cheryl H., Brown, Peter J., Baell, Jonathan B., Walters, Michael A.
Publicado 2017

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

por Bezerra, Gustavo A., Holenstein, Alexander, Foster, William R., Xie, Bing, Hicks, Kevin G., Bürer, Céline, Lutz, Seraina, Mukherjee, Ayan, Sarkar, Dipika, Bhattacharya, Debomita, Rutter, Jared, Talukdar, Arindam, Brown, Peter J., Luo, Minkui, Shi, Lei, Froese, D. Sean, Yue, Wyatt W.
Publicado 2021

Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21

por Göricke, Fabian, Vu, Victoria, Smith, Leanna, Scheib, Ulrike, Böhm, Raphael, Akkilic, Namik, Wohlfahrt, Gerd, Weiske, Jörg, Bömer, Ulf, Brzezinka, Krzysztof, Lindner, Niels, Lienau, Philip, Gradl, Stefan, Beck, Hartmut, Brown, Peter J., Santhakumar, Vijayaratnam, Vedadi, Masoud, Barsyte-Lovejoy, Dalia, Arrowsmith, Cheryl H., Schmees, Norbert, Petersen, Kirstin
Publicado 2023

Probing the SAM Binding Site of SARS-CoV-2 Nsp14 In Vitro Using SAM Competitive Inhibitors Guides Developing Selective Bisubstrate Inhibitors

por Devkota, Kanchan, Schapira, Matthieu, Perveen, Sumera, Khalili Yazdi, Aliakbar, Li, Fengling, Chau, Irene, Ghiabi, Pegah, Hajian, Taraneh, Loppnau, Peter, Bolotokova, Albina, Satchell, Karla J.F., Wang, Ke, Li, Deyao, Liu, Jing, Smil, David, Luo, Minkui, Jin, Jian, Fish, Paul V., Brown, Peter J., Vedadi, Masoud
Publicado 2021

A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II

por Liu, Yanli, Iqbal, Aman, Li, Weiguo, Ni, Zuyao, Wang, Yalong, Ramprasad, Jurupula, Abraham, Karan Joshua, Zhang, Mengmeng, Zhao, Dorothy Yanling, Qin, Su, Loppnau, Peter, Jiang, Honglv, Guo, Xinghua, Brown, Peter J., Zhen, Xuechu, Xu, Guoqiang, Mekhail, Karim, Ji, Xingyue, Bedford, Mark T., Greenblatt, Jack F., Min, Jinrong
Publicado 2022

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

por Harding, Rachel J., Franzoni, Ivan, Mann, Mandeep K., Szewczyk, Magdalena M., Mirabi, Bijan, Ferreira de Freitas, Renato, Owens, Dominic D. G., Ackloo, Suzanne, Scheremetjew, Alexej, Juarez-Ornelas, Kevin A., Sanichar, Randy, Baker, Rachel J., Dank, Christian, Brown, Peter J., Barsyte-Lovejoy, Dalia, Santhakumar, Vijayaratnam, Schapira, Matthieu, Lautens, Mark, Arrowsmith, Cheryl H.
Publicado 2023

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

por Senisterra, Guillermo, Wu, Hong, Allali-Hassani, Abdellah, Wasney, Gregory A., Barsyte-Lovejoy, Dalia, Dombrovski, Ludmila, Dong, Aiping, Nguyen, Kong T., Smil, David, Bolshan, Yuri, Hajian, Taraneh, He, Hao, Seitova, Alma, Chau, Irene, Li, Fengling, Poda, Gennadiy, Couture, Jean-François, Brown, Peter J., Al-Awar, Rima, Schapira, Matthieu, Arrowsmith, Cheryl H., Vedadi, Masoud
Publicado 2012

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1

por Harrison, Joseph S, Cornett, Evan M, Goldfarb, Dennis, DaRosa, Paul A, Li, Zimeng M, Yan, Feng, Dickson, Bradley M, Guo, Angela H, Cantu, Daniel V, Kaustov, Lilia, Brown, Peter J, Arrowsmith, Cheryl H, Erie, Dorothy A, Major, Michael B, Klevit, Rachel E, Krajewski, Krzysztof, Kuhlman, Brian, Strahl, Brian D, Rothbart, Scott B
Publicado 2016