Genetics in Atopic Dermatitis: Historical Perspective and Future Prospects

por BROWN, Sara J., ELIAS, Martina S., BRADLEY, Maria
Publicado 2020

One remarkable molecule: Filaggrin

por Brown, Sara J., McLean, W. H. Irwin
Publicado 2011

In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers

por Paul, Argho Aninda, Szulc, Natalia A., Kobiela, Adrian, Brown, Sara J., Pokrzywa, Wojciech, Gutowska-Owsiak, Danuta
Publicado 2023

Chromosome 11q13.5 variant associated with childhood eczema: An effect supplementary to filaggrin mutations

por O'Regan, Gráinne M., Campbell, Linda E., Cordell, Heather J., Irvine, Alan D., McLean, W.H. Irwin, Brown, Sara J.
Publicado 2010

Intragenic Copy Number Variation within Filaggrin Contributes to the Risk of Atopic Dermatitis with a Dose-Dependent Effect

por Brown, Sara J, Kroboth, Karin, Sandilands, Aileen, Campbell, Linda E, Pohler, Elizabeth, Kezic, Sanja, Cordell, Heather J, McLean, W H Irwin, Irvine, Alan D
Publicado 2012

Heterozygous Mutations in AAGAB Cause Type 1 Punctate Palmoplantar Keratoderma with Evidence for Increased Growth Factor Signaling

por Pöhler, Elizabeth, Zamiri, Mozheh, Harkins, Catriona P, Salas-Alanis, Julio C, Perkins, William, Smith, Frances J D, Irwin McLean, W H, Brown, Sara J
Publicado 2013

Functional and proteomic analysis of a full thickness filaggrin-deficient skin organoid model

por Elias, Martina S., Wright, Sheila C., Nicholson, William V., Morrison, Kimberley D., Prescott, Alan R., Ten Have, Sara, Whitfield, Phillip D., Lamond, Angus I., Brown, Sara J.
Publicado 2019

Improved Annotation of 3′ Untranslated Regions and Complex Loci by Combination of Strand-Specific Direct RNA Sequencing, RNA-Seq and ESTs

por Schurch, Nicholas J., Cole, Christian, Sherstnev, Alexander, Song, Junfang, Duc, Céline, Storey, Kate G., McLean, W. H. Irwin, Brown, Sara J., Simpson, Gordon G., Barton, Geoffrey J.
Publicado 2014

Identification of atopic dermatitis subgroups in children from 2 longitudinal birth cohorts

por Paternoster, Lavinia, Savenije, Olga E.M., Heron, Jon, Evans, David M., Vonk, Judith M., Brunekreef, Bert, Wijga, Alet H., Henderson, A. John, Koppelman, Gerard H., Brown, Sara J.
Publicado 2018

Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention

por Simpson, Eric L., Chalmers, Joanne R., Hanifin, Jon M., Thomas, Kim S., Cork, Michael J., McLean, W.H. Irwin, Brown, Sara J., Chen, Zunqiu, Chen, Yiyi, Williams, Hywel C.
Publicado 2014

Filaggrin genotype does not determine the skin's threshold to UV-induced erythema

por Forbes, Deborah, Johnston, Leona, Gardner, June, MacCallum, Stephanie F., Campbell, Linda E., Dinkova-Kostova, Albena T., McLean, W.H. Irwin, Ibbotson, Sally H., Dawe, Robert S., Brown, Sara J.
Publicado 2016

The Microevolution and Epidemiology of Staphylococcus aureus Colonization during Atopic Eczema Disease Flare

por Harkins, Catriona P., Pettigrew, Kerry A., Oravcová, Katarina, Gardner, June, Hearn, R.M. Ross, Rice, Debbie, Mather, Alison E., Parkhill, Julian, Brown, Sara J., Proby, Charlotte M., Holden, Matthew T.G.
Publicado 2018

Filaggrin-stratified transcriptomic analysis of pediatric skin identifies mechanistic pathways in patients with atopic dermatitis

por Cole, Christian, Kroboth, Karin, Schurch, Nicholas J., Sandilands, Aileen, Sherstnev, Alexander, O'Regan, Grainne M., Watson, Rosemarie M., Irwin McLean, W.H., Barton, Geoffrey J., Irvine, Alan D., Brown, Sara J.
Publicado 2014

South African amaXhosa patients with atopic dermatitis have decreased levels of filaggrin breakdown products but no loss-of-function mutations in filaggrin()

por Thawer-Esmail, Fatemah, Jakasa, Ivone, Todd, Gail, Wen, Yaran, Brown, Sara J., Kroboth, Karin, Campbell, Linda E., O'Regan, Grainne M., McLean, W.H. Irwin, Irvine, Alan D., Kezic, Sanja, Sandilands, Aileen
Publicado 2014

Mutations in the SASPase gene (ASPRV1) are not associated with atopic eczema or clinically dry skin

por Sandilands, Aileen, Brown, Sara J., Goh, Christabelle S., Pohler, Elizabeth, Wilson, Neil J., Campbell, Linda E., Miyamoto, Kenichi, Kubo, Akiharu, Irvine, Alan D., Thawer-Esmail, Fatema, Munro, Colin S., McLean, W.H. Irwin, Kudoh, Jun, Amagai, Masayuki, Matsui, Takeshi
Publicado 2012

Filaggrin gene mutation associations with peanut allergy persist despite variations in peanut allergy diagnostic criteria or asthma status

por Asai, Yuka, Greenwood, Celia, Hull, Peter R., Alizadehfar, Reza, Ben-Shoshan, Moshe, Brown, Sara J., Campbell, Linda, Michel, Deborah L., Bussières, Johanne, Rousseau, François, Fujiwara, T. Mary, Morgan, Kenneth, Irvine, Alan D., McLean, W.H. Irwin, Clarke, Ann
Publicado 2013

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a...

por Naeem, Aishath S., Tommasi, Cristina, Cole, Christian, Brown, Stuart J., Zhu, Yanan, Way, Benjamin, Willis Owen, Saffron A.G., Moffatt, Miriam, Cookson, William O., Harper, John I., Di, Wei-Li, Brown, Sara J., Reinheckel, Thomas, O'Shaughnessy, Ryan F.L.
Publicado 2017

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP tria...

por Chalmers, Joanne R., Haines, Rachel H., Mitchell, Eleanor J., Thomas, Kim S., Brown, Sara J., Ridd, Matthew, Lawton, Sandra, Simpson, Eric L., Cork, Michael J., Sach, Tracey H., Bradshaw, Lucy E., Montgomery, Alan A., Boyle, Robert J., Williams, Hywel C.
Publicado 2017

Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy

por Brough, Helen A., Liu, Andrew H., Sicherer, Scott, Makinson, Kerry, Douiri, Abdel, Brown, Sara J., Stephens, Alick C., Irwin McLean, W.H., Turcanu, Victor, Wood, Robert A., Jones, Stacie M., Burks, Wesley, Dawson, Peter, Stablein, Donald, Sampson, Hugh, Lack, Gideon
Publicado 2015

Human and computational models of atopic dermatitis: A review and perspectives by an expert panel of the International Eczema Council

por Eyerich, Kilian, Brown, Sara J., Perez White, Bethany E., Tanaka, Reiko J., Bissonette, Robert, Dhar, Sandipan, Bieber, Thomas, Hijnen, Dirk J., Guttman-Yassky, Emma, Irvine, Alan, Thyssen, Jacob P., Vestergaard, Christian, Werfel, Thomas, Wollenberg, Andreas, Paller, Amy S., Reynolds, Nick J.
Publicado 2018