Identifying appropriate phase II trial designs

por Brown, Sarah R
Publicado 2011

First description of subglacial megalineations from the late Paleozoic ice age in southern Africa

por Andrews, Graham D., McGrady, Andrew T., Brown, Sarah R., Maynard, Shannon M.
Publicado 2019

Phase II trial designs for complex interventions: a single-arm single-stage design for clustered continuous outcomes

por Wilson, Duncan T, Walwyn, Rebecca EA, Brown, Sarah R, Brown, Julia, Farrin, Amanda J
Publicado 2015

Statistical challenges in assessing potential efficacy of complex interventions in pilot or feasibility studies

por Wilson, Duncan T, Walwyn, Rebecca E A, Brown, Julia, Farrin, Amanda J, Brown, Sarah R
Publicado 2015

SELIMETRY—a multicentre I-131 dosimetry trial: a clinical perspective

por Wadsley, Jonathan, Gregory, Rebecca, Flux, Glenn, Newbold, Kate, Du, Yong, Moss, Laura, Hall, Andrew, Flanagan, Louise, Brown, Sarah R
Publicado 2017

A Road Map for Designing Phase I Clinical Trials of Radiotherapy–Novel Agent Combinations

por Brown, Sarah R., Hinsley, Samantha, Hall, Emma, Hurt, Chris, Baird, Richard D., Forster, Martin, Scarsbrook, Andrew F., Adams, Richard A.
Publicado 2022

Implementation of the Time-to-Event Continuous Reassessment Method Design in a Phase I Platform Trial Testing Novel Radiotherapy-Drug Combinations—CONCORDE

por Walker, Katrina, Hinsley, Samantha, Phillip, Rachel, Oughton, Jamie B., Murden, Geraldine, Chalmers, Anthony J., Faivre-Finn, Corinne, Greystoke, Alastair, Brown, Sarah R.
Publicado 2022

Effect of AZD4017, a Selective 11β-HSD1 Inhibitor, on Bone Turnover Markers in Postmenopausal Osteopenia

por Abbas, Afroze, Schini, Marian, Ainsworth, Gemma, Brown, Sarah R, Oughton, Jamie, Crowley, Rachel K, Cooper, Mark S, Fairclough, Rebecca J, Eastell, Richard, Stewart, Paul M
Publicado 2022

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol...

por Brown, Sarah R., Hall, Andrew, Buckley, Hannah L., Flanagan, Louise, Gonzalez de Castro, David, Farnell, Kate, Moss, Laura, Gregory, Rebecca, Newbold, Kate, Du, Yong, Flux, Glenn, Wadsley, Jonathan
Publicado 2019

Ixazomib with cyclophosphamide and dexamethasone in relapsed or refractory myeloma: MUKeight phase II randomised controlled trial results

por Auner, Holger W., Brown, Sarah R., Walker, Katrina, Kendall, Jessica, Dawkins, Bryony, Meads, David, Morgan, Gareth J., Kaiser, Martin F., Cook, Mark, Roberts, Sadie, Parrish, Christopher, Cook, Gordon
Publicado 2022

The TICOPA protocol (TIght COntrol of Psoriatic Arthritis): a randomised controlled trial to compare intensive management versus standard care in early psoriatic arthritis

por Coates, Laura C, Navarro-Coy, Nuria, Brown, Sarah R, Brown, Sarah, McParland, Lucy, Collier, Howard, Skinner, Emma, Law, Jennifer, Moverley, Anna, Pavitt, Sue, Hulme, Claire, Emery, Paul, Conaghan, Philip G, Helliwell, Philip S
Publicado 2013

A phase IB and randomised phase IIA trial of CApecitabine plus Radium-223 (Xofigo™) in breast cancer patients with BONe metastases: CARBON trial results

por Winter, Matthew, Coleman, Rob, Kendall, Jessica, Palmieri, Carlo, Twelves, Chris, Howell, Sacha, MacPherson, Iain, Wilson, Caroline, Purohit, Kash, Gath, Jacqui, Taylor, Christine, Eastell, Richard, Murden, Geraldine, Brown, Sarah R., Rathbone, Emma, Brown, Janet
Publicado 2022

The Role of Pretherapy Quantitative Imaging and Dosimetry in Radioiodine Therapy for Advanced Thyroid Cancer

por Taprogge, Jan, Abreu, Carla, Yusuf, Siraj, Ainsworth, Gemma, Phillip, Rachel H., Gear, Jonathan I., Gregory, Rebecca, Leek, Francesca, Murray, Iain, Coulson, Amy B., Brown, Sarah R., Du, Yong, Newbold, Kate, Wadsley, Jonathan, Flux, Glenn D.
Publicado 2023

A clinical prediction model for outcome and therapy delivery in transplant-ineligible patients with myeloma (UK Myeloma Research Alliance Risk Profile): a development and validatio...

por Cook, Gordon, Royle, Kara-Louise, Pawlyn, Charlotte, Hockaday, Anna, Shah, Vallari, Kaiser, Martin F, Brown, Sarah R, Gregory, Walter M, Child, J Anthony, Davies, Faith E, Morgan, Gareth J, Cairns, David A, Jackson, Graham H
Publicado 2019

HER2 overexpression and amplification as a potential therapeutic target in colorectal cancer: analysis of 3256 patients enrolled in the QUASAR, FOCUS and PICCOLO colorectal cancer...

por Richman, Susan D, Southward, Katie, Chambers, Philip, Cross, Debra, Barrett, Jennifer, Hemmings, Gemma, Taylor, Morag, Wood, Henry, Hutchins, Gordon, Foster, Joseph M, Oumie, Assa, Spink, Karen G, Brown, Sarah R, Jones, Marc, Kerr, David, Handley, Kelly, Gray, Richard, Seymour, Matthew, Quirke, Philip
Publicado 2016

PRISM protocol: a randomised phase II trial of nivolumab in combination with alternatively scheduled ipilimumab in first-line treatment of patients with advanced or metastatic rena...

por Buckley, Hannah L., Collinson, Fiona J., Ainsworth, Gemma, Poad, Heather, Flanagan, Louise, Katona, Eszter, Howard, Helen C., Murden, Geraldine, Banks, Rosamonde E., Brown, Joanne, Velikova, Galina, Waddell, Tom, Fife, Kate, Nathan, Paul D., Larkin, James, Powles, Thomas, Brown, Sarah R., Vasudev, Naveen S.
Publicado 2019

Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomi...

por Seymour, Matthew T, Brown, Sarah R, Middleton, Gary, Maughan, Timothy, Richman, Susan, Gwyther, Stephen, Lowe, Catherine, Seligmann, Jennifer F, Wadsley, Jonathan, Maisey, Nick, Chau, Ian, Hill, Mark, Dawson, Lesley, Falk, Stephen, O'Callaghan, Ann, Benstead, Kim, Chambers, Philip, Oliver, Alfred, Marshall, Helen, Napp, Vicky, Quirke, Phil
Publicado 2013

Response to COVID-19 Vaccines in Patients Receiving Intensified Post-ASCT Therapy with Daratumumab, Lenalidomide, Bortezomib (Dara-VR) Due to Ultra-High Risk (UHiR) Newly Diagnosed...

por Jenner, Matthew W, Hall, Andrew, Faustini, Sian E, Pitchford, Alexandra, de Tute, Ruth M., Roberts, Sadie, Ingleson, Emma, Bowles, Kristian M, Garg, Mamta, Lokare, Anand, Messiou, Christina, Jackson, Graham, Pratt, Guy, Cook, Gordon, Owen, Roger G, Brown, Sarah R, Drayson, Mark T, Kaiser, Martin F.
Publicado 2021

Carfilzomib or bortezomib in combination with cyclophosphamide and dexamethasone followed by carfilzomib maintenance for patients with multiple myeloma after one prior therapy: res...

por Yong, Kwee L., Hinsley, Samantha, Auner, Holger W., Bygrave, Ceri, Kaiser, Martin F., Ramasamy, Karthik, de Tute, Ruth M., Sherratt, Debbie, Flanagan, Louise, Garg, Mamta, Hawkins, Stephen, Williams, Catherine, Cavenagh, Jamie, Rabin, Neil K., Croft, James, Morgan, Gareth, Davies, Faith, Owen, Roger G., Brown, Sarah R.
Publicado 2021