Human sperm ion channel (dys)function: implications for fertilization

por Brown, Sean G, Publicover, Stephen J, Barratt, Christopher L R, Martins da Silva, Sarah J
Publicado 2019

SKF96365 modulates activity of CatSper channels in human sperm

por Torrezan-Nitao, Elis, Brown, Sean G, Lefievre, Linda, Morris, Jennifer, Correia, Joao, Harper, Claire V, Publicover, Stephen
Publicado 2023

Elevated and Sustained Intracellular Calcium Signalling Is Necessary for Efficacious Induction of the Human Sperm Acrosome Reaction

por Prajapati, Priyanka, Kane, Shruti, McBrinn, Rachel C., Dean, Morven S., Martins da Silva, Sarah J., Brown, Sean G.
Publicado 2022

Complex CatSper-dependent and independent [Ca(2+)](i) signalling in human spermatozoa induced by follicular fluid

por Brown, Sean G., Costello, Sarah, Kelly, Mark C., Ramalingam, Mythili, Drew, Ellen, Publicover, Stephen J., Barratt, Christopher L.R., Da Silva, Sarah Martins
Publicado 2017

Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

por Brown, Sean G, Miller, Melissa R, Lishko, Polina V, Lester, Douglas H, Publicover, Stephen J, Barratt, Christopher L R, Martins Da Silva, Sarah
Publicado 2018

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity

por Tardif, Steve, Madamidola, Oladipo A., Brown, Sean G., Frame, Lorna, Lefièvre, Linda, Wyatt, Paul G., Barratt, Christopher L.R., Martins Da Silva, Sarah J.
Publicado 2014

Single-cell analysis of [Ca(2+)](i) signalling in sub-fertile men: characteristics and relation to fertilization outcome

por Kelly, Mark C, Brown, Sean G, Costello, Sarah M, Ramalingam, Mythili, Drew, Ellen, Publicover, Stephen J, Barratt, Christopher L R, Martins Da Silva, Sarah
Publicado 2018

Novel pharmacological actions of trequinsin hydrochloride improve human sperm cell motility and function

por McBrinn, Rachel C., Fraser, Joanna, Hope, Anthony G., Gray, David W., Barratt, Christopher L.R., Martins da Silva, Sarah J., Brown, Sean G.
Publicado 2019

Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF

por Brown, Sean G., Publicover, Stephen J., Mansell, Steven A., Lishko, Polina V., Williams, Hannah L., Ramalingam, Mythili, Wilson, Stuart M., Barratt, Christopher L.R., Sutton, Keith A., Da Silva, Sarah Martins
Publicado 2016

Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem

por Martins da Silva, Sarah J., Brown, Sean G., Sutton, Keith, King, Louise V., Ruso, Halil, Gray, David W., Wyatt, Paul G., Kelly, Mark C., Barratt, Christopher L.R., Hope, Anthony G.
Publicado 2017

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa

por Williams, Hannah L., Mansell, Steven, Alasmari, Wardah, Brown, Sean G., Wilson, Stuart M., Sutton, Keith A., Miller, Melissa R., Lishko, Polina V., Barratt, Christopher L.R., Publicover, Steven J., Martins da Silva, Sarah
Publicado 2015

A spontaneous increase in intracellular Ca(2+) in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K(+) channels

por Fernandes, Gonçalo, Dasai, Navin, Kozlova, Natalia, Mojadadi, Albaraa, Gall, Mandy, Drew, Ellen, Barratt, Evelyn, Madamidola, Oladipo A., Brown, Sean G., Milne, Alison M., Martins da Silva, Sarah J., Whalley, Katherine M., Barratt, Christopher L.R., Jovanović, Aleksandar
Publicado 2016