A Reporter Screen in a Human Haploid Cell Line Identifies CYLD as a Constitutive Inhibitor of NF-κB

por Lee, Clarissa C., Carette, Jan E., Brummelkamp, Thijn R., Ploegh, Hidde L.
Publicado 2013

Identification of host cell factors required for intoxication through use of modified cholera toxin

por Guimaraes, Carla P., Carette, Jan E., Varadarajan, Malini, Antos, John, Popp, Maximilian W., Spooner, Eric, Brummelkamp, Thijn R., Ploegh, Hidde L.
Publicado 2011

Haploid genetic screens identify genetic vulnerabilities to microtubule‐targeting agents

por Gerhards, Nora M., Blomen, Vincent A., Mutlu, Merve, Nieuwenhuis, Joppe, Howald, Denise, Guyader, Charlotte, Jonkers, Jos, Brummelkamp, Thijn R., Rottenberg, Sven
Publicado 2018

SLFN11 can sensitize tumor cells towards IFN-γ-mediated T cell killing

por Mezzadra, Riccardo, de Bruijn, Marjolein, Jae, Lucas T., Gomez-Eerland, Raquel, Duursma, Anja, Scheeren, Ferenc A., Brummelkamp, Thijn R., Schumacher, Ton N.
Publicado 2019

Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

por Essletzbichler, Patrick, Konopka, Tomasz, Santoro, Federica, Chen, Doris, Gapp, Bianca V., Kralovics, Robert, Brummelkamp, Thijn R., Nijman, Sebastian M.B., Bürckstümmer, Tilmann
Publicado 2014

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

por Heijink, Anne Margriet, Talens, Francien, Jae, Lucas T., van Gijn, Stephanie E., Fehrmann, Rudolf S. N., Brummelkamp, Thijn R., van Vugt, Marcel A. T. M.
Publicado 2019

Haploid Genetic Screen Reveals a Profound and Direct Dependence on Cholesterol for Hantavirus Membrane Fusion

por Kleinfelter, Lara M., Jangra, Rohit K., Jae, Lucas T., Herbert, Andrew S., Mittler, Eva, Stiles, Katie M., Wirchnianski, Ariel S., Kielian, Margaret, Brummelkamp, Thijn R., Dye, John M., Chandran, Kartik
Publicado 2015

A generic strategy for CRISPR-Cas9-mediated gene tagging

por Lackner, Daniel H., Carré, Alexia, Guzzardo, Paloma M., Banning, Carina, Mangena, Ramu, Henley, Tom, Oberndorfer, Sarah, Gapp, Bianca V., Nijman, Sebastian M.B., Brummelkamp, Thijn R., Bürckstümmer, Tilmann
Publicado 2015

A Mediator-cohesin axis controls heterochromatin domain formation

por Haarhuis, Judith H. I., van der Weide, Robin H., Blomen, Vincent A., Flach, Koen D., Teunissen, Hans, Willems, Laureen, Brummelkamp, Thijn R., Rowland, Benjamin D., de Wit, Elzo
Publicado 2022

A Single Residue in Ebola Virus Receptor NPC1 Influences Cellular Host Range in Reptiles

por Ndungo, Esther, Herbert, Andrew S., Raaben, Matthijs, Obernosterer, Gregor, Biswas, Rohan, Miller, Emily Happy, Wirchnianski, Ariel S., Carette, Jan E., Brummelkamp, Thijn R., Whelan, Sean P., Dye, John M., Chandran, Kartik
Publicado 2016

Global gene disruption in human cells to assign genes to phenotypes

por Carette, Jan E., Guimaraes, Carla P., Wuethrich, Irene, Blomen, Vincent A., Varadarajan, Malini, Sun, Chong, Bell, George, Yuan, Bingbing, Muellner, Markus K., Nijman, Sebastian M., Ploegh, Hidde L., Brummelkamp, Thijn R.
Publicado 2011

MND1 enables homologous recombination in somatic cells primarily outside the context of replication

por Koob, Lisa, Friskes, Anoek, van Bergen, Louise, Feringa, Femke M., van den Broek, Bram, Koeleman, Emma S., van Beek, Ellis, Schubert, Michael, Blomen, Vincent A., Brummelkamp, Thijn R., Krenning, Lenno, Medema, René H.
Publicado 2023

Niemann-Pick C1 Is Essential for Ebolavirus Replication and Pathogenesis In Vivo

por Herbert, Andrew S., Davidson, Cristin, Kuehne, Ana I., Bakken, Russell, Braigen, Stephen Z., Gunn, Kathryn E., Whelan, Sean P., Brummelkamp, Thijn R., Twenhafel, Nancy A., Chandran, Kartik, Walkley, Steven U., Dye, John M.
Publicado 2015

The cohesin acetylation cycle controls chromatin loop length through a PDS5A brake mechanism

por van Ruiten, Marjon S., van Gent, Démi, Sedeño Cacciatore, Ángela, Fauster, Astrid, Willems, Laureen, Hekkelman, Maarten L., Hoekman, Liesbeth, Altelaar, Maarten, Haarhuis, Judith H. I., Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
Publicado 2022

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

por Tsvetkov, Peter, Mendillo, Marc L, Zhao, Jinghui, Carette, Jan E, Merrill, Parker H, Cikes, Domagoj, Varadarajan, Malini, van Diemen, Ferdy R, Penninger, Josef M, Goldberg, Alfred L, Brummelkamp, Thijn R, Santagata, Sandro, Lindquist, Susan
Publicado 2015

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

por Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Yilmaz, Omer H., Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Peterson, Tim R., Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary B., Sabatini, David M.
Publicado 2012

Ebola virus entry requires the cholesterol transporter Niemann-Pick C1

por Carette, Jan E., Raaben, Matthijs, Wong, Anthony C., Herbert, Andrew S., Obernosterer, Gregor, Mulherkar, Nirupama, Kuehne, Ana I., Kranzusch, Philip J., Griffin, April M., Ruthel, Gordon, Cin, Paola Dal, Dye, John M., Whelan, Sean P., Chandran, Kartik, Brummelkamp, Thijn R.
Publicado 2011

FIRRM/C1orf112 mediates resolution of homologous recombination intermediates in response to DNA interstrand crosslinks

por Mazouzi, Abdelghani, Moser, Sarah C., Abascal, Federico, van den Broek, Bram, Del Castillo Velasco-Herrera, Martin, van der Heijden, Ingrid, Hekkelman, Maarten, Drenth, Anne Paulien, van der Burg, Eline, Kroese, Lona J., Jalink, Kees, Adams, David J., Jonkers, Jos, Brummelkamp, Thijn R.
Publicado 2023

The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

por Haarhuis, Judith H.I., van der Weide, Robin H., Blomen, Vincent A., Yáñez-Cuna, J. Omar, Amendola, Mario, van Ruiten, Marjon S., Krijger, Peter H.L., Teunissen, Hans, Medema, René H., van Steensel, Bas, Brummelkamp, Thijn R., de Wit, Elzo, Rowland, Benjamin D.
Publicado 2017

Identification of an alternative triglyceride biosynthesis pathway

por McLelland, Gian-Luca, Lopez-Osias, Marta, Verzijl, Cristy R. C., Ellenbroek, Brecht D., Oliveira, Rafaela A., Boon, Nicolaas J., Dekker, Marleen, van den Hengel, Lisa G., Ali, Rahmen, Janssen, Hans, Song, Ji-Ying, Krimpenfort, Paul, van Zutphen, Tim, Jonker, Johan W., Brummelkamp, Thijn R.
Publicado 2023