Patient-derived tumour xenografts for breast cancer drug discovery

por Cassidy, John W, Batra, Ankita S, Greenwood, Wendy, Bruna, Alejandra
Publicado 2016

The Promise of Patient-Derived Preclinical Models to Accelerate the Implementation of Personalised Medicine for Children with Neuroblastoma

por Tucker, Elizabeth R., George, Sally, Angelini, Paola, Bruna, Alejandra, Chesler, Louis
Publicado 2021

Metabolic imaging with hyperpolarized [1-(13)C] pyruvate in patient-derived preclinical mouse models of breast cancer

por Ros, Susana, Wright, Alan J., Bruna, Alejandra, Caldas, Carlos, Brindle, Kevin M.
Publicado 2021

Predicting Cancer Drug Response In Vivo by Learning an Optimal Feature Selection of Tumour Molecular Profiles

por Nguyen, Linh C., Naulaerts, Stefan, Bruna, Alejandra, Ghislat, Ghita, Ballester, Pedro J.
Publicado 2021

Wnt Signaling in the Breast: From Development to Disease

por Abreu de Oliveira, Willy Antoni, El Laithy, Youssef, Bruna, Alejandra, Annibali, Daniela, Lluis, Frederic
Publicado 2022

Intersect-then-combine approach: improving the performance of somatic variant calling in whole exome sequencing data using multiple aligners and callers

por Callari, Maurizio, Sammut, Stephen-John, De Mattos-Arruda, Leticia, Bruna, Alejandra, Rueda, Oscar M., Chin, Suet-Feung, Caldas, Carlos
Publicado 2017

Context-Specific Effects of TGF-β/SMAD3 in Cancer Are Modulated by the Epigenome

por Tufegdzic Vidakovic, Ana, Rueda, Oscar M., Vervoort, Stephin J., Sati Batra, Ankita, Goldgraben, Mae Akilina, Uribe-Lewis, Santiago, Greenwood, Wendy, Coffer, Paul J., Bruna, Alejandra, Caldas, Carlos
Publicado 2015

Computational approach to discriminate human and mouse sequences in patient-derived tumour xenografts

por Callari, Maurizio, Batra, Ankita Sati, Batra, Rajbir Nath, Sammut, Stephen-John, Greenwood, Wendy, Clifford, Harry, Hercus, Colin, Chin, Suet-Feung, Bruna, Alejandra, Rueda, Oscar M., Caldas, Carlos
Publicado 2018

MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models

por Xue, Zheng, Vis, Daniel J., Bruna, Alejandra, Sustic, Tonci, van Wageningen, Sake, Batra, Ankita Sati, Rueda, Oscar M., Bosdriesz, Evert, Caldas, Carlos, Wessels, Lodewyk F. A., Bernards, René
Publicado 2018

Anti‐tumoural activity of the G‐quadruplex ligand pyridostatin against BRCA1/2‐deficient tumours

por Groelly, Florian J, Porru, Manuela, Zimmer, Jutta, Benainous, Hugo, De Visser, Yanti, Kosova, Anastasiya A, Di Vito, Serena, Serra, Violeta, Ryan, Anderson, Leonetti, Carlo, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena
Publicado 2022

SOX4 can redirect TGF-β-mediated SMAD3-transcriptional output in a context-dependent manner to promote tumorigenesis

por Vervoort, Stephin J, Lourenço, Ana Rita, Tufegdzic Vidakovic, Ana, Mocholi, Enric, Sandoval, José L, Rueda, Oscar M, Frederiks, Cynthia, Pals, Cornelieke, Peeters, Janneke G C, Caldas, Carlos, Bruna, Alejandra, Coffer, Paul J
Publicado 2018

MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer

por Dinami, Roberto, Pompili, Luca, Petti, Eleonora, Porru, Manuela, D'Angelo, Carmen, Di Vito, Serena, Rizzo, Angela, Campani, Virginia, De Rosa, Giuseppe, Bruna, Alejandra, Serra, Violeta, Mano, Miguel, Giacca, Mauro, Leonetti, Carlo, Ciliberto, Gennaro, Tarsounas, Madalena, Stoppacciaro, Antonella, Schoeftner, Stefan, Biroccio, Annamaria
Publicado 2022

BRCA1 and BRCA2 tumor suppressors protect against endogenous acetaldehyde toxicity

por Tacconi, Eliana MC, Lai, Xianning, Folio, Cecilia, Porru, Manuela, Zonderland, Gijs, Badie, Sophie, Michl, Johanna, Sechi, Irene, Rogier, Mélanie, Matía García, Verónica, Batra, Ankita Sati, Rueda, Oscar M, Bouwman, Peter, Jonkers, Jos, Ryan, Anderson, Reina‐San‐Martin, Bernardo, Hui, Joannie, Tang, Nelson, Bruna, Alejandra, Biroccio, Annamaria, Tarsounas, Madalena
Publicado 2017

Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response

por Georgopoulou, Dimitra, Callari, Maurizio, Rueda, Oscar M., Shea, Abigail, Martin, Alistair, Giovannetti, Agnese, Qosaj, Fatime, Dariush, Ali, Chin, Suet-Feung, Carnevalli, Larissa S., Provenzano, Elena, Greenwood, Wendy, Lerda, Giulia, Esmaeilishirazifard, Elham, O’Reilly, Martin, Serra, Violeta, Bressan, Dario, Mills, Gordon B., Ali, H. Raza, Cosulich, Sabina S., Hannon, Gregory J., Bruna, Alejandra, Caldas, Carlos
Publicado 2021

Chlorambucil targets BRCA1/2‐deficient tumours and counteracts PARP inhibitor resistance

por Tacconi, Eliana MC, Badie, Sophie, De Gregoriis, Giuliana, Reisländer, Timo, Lai, Xianning, Porru, Manuela, Folio, Cecilia, Moore, John, Kopp, Arnaud, Baguña Torres, Júlia, Sneddon, Deborah, Green, Marcus, Dedic, Simon, Lee, Jonathan W, Batra, Ankita Sati, Rueda, Oscar M, Bruna, Alejandra, Leonetti, Carlo, Caldas, Carlos, Cornelissen, Bart, Brino, Laurent, Ryan, Anderson, Biroccio, Annamaria, Tarsounas, Madalena
Publicado 2019

ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response

por Nagarajan, Sankari, Rao, Shalini V., Sutton, Joseph, Cheeseman, Danya, Dunn, Shanade, Papachristou, Evangelia K., Prada, Jose-Enrique Gonzalez, Couturier, Dominique-Laurent, Kumar, Sanjeev, Kishore, Kamal, Chilamakuri, Chandra Sekhar Reddy, Glont, Silvia-Elena, Goode, Emily Archer, Brodie, Cara, Guppy, Naomi, Natrajan, Rachael, Bruna, Alejandra, Caldas, Carlos, Russell, Alasdair, Siersbæk, Rasmus, Yusa, Kosuke, Chernukhin, Igor, Carroll, Jason S.
Publicado 2020

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

por Batra, Rajbir Nath, Lifshitz, Aviezer, Vidakovic, Ana Tufegdzic, Chin, Suet-Feung, Sati-Batra, Ankita, Sammut, Stephen-John, Provenzano, Elena, Ali, H. Raza, Dariush, Ali, Bruna, Alejandra, Murphy, Leigh, Purushotham, Arnie, Ellis, Ian, Green, Andrew, Garrett-Bakelman, Francine E., Mason, Chris, Melnick, Ari, Aparicio, Samuel A. J. R., Rueda, Oscar M., Tanay, Amos, Caldas, Carlos
Publicado 2021

ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

por Holland, Daniel G, Burleigh, Angela, Git, Anna, Goldgraben, Mae A, Perez-Mancera, Pedro A, Chin, Suet-Feung, Hurtado, Antonio, Bruna, Alejandra, Ali, H Raza, Greenwood, Wendy, Dunning, Mark J, Samarajiwa, Shamith, Menon, Suraj, Rueda, Oscar M, Lynch, Andy G, McKinney, Steven, Ellis, Ian O, Eaves, Connie J, Carroll, Jason S, Curtis, Christina, Aparicio, Samuel, Caldas, Carlos
Publicado 2011

Progesterone receptor modulates estrogen receptor-α action in breast cancer

por Mohammed, Hisham, Russell, I. Alasdair, Stark, Rory, Rueda, Oscar M., Hickey, Theresa E., Tarulli, Gerard A., Serandour, Aurelien A. A., Birrell, Stephen N., Bruna, Alejandra, Saadi, Amel, Menon, Suraj, Hadfield, James, Pugh, Michelle, Raj, Ganesh V., Brown, Gordon D., D’Santos, Clive, Robinson, Jessica L. L., Silva, Grace, Launchbury, Rosalind, Perou, Charles M., Stingl, John, Caldas, Carlos, Tilley, Wayne D., Carroll, Jason S.
Publicado 2015

Global transcriptional analysis identifies a novel role for SOX4 in tumor-induced angiogenesis

por Vervoort, Stephin J, de Jong, Olivier G, Roukens, M Guy, Frederiks, Cynthia L, Vermeulen, Jeroen F, Lourenço, Ana Rita, Bella, Laura, Vidakovic, Ana Tufegdzic, Sandoval, José L, Moelans, Cathy, van Amersfoort, Miranda, Dallman, Margaret J, Bruna, Alejandra, Caldas, Carlos, Nieuwenhuis, Edward, van der Wall, Elsken, Derksen, Patrick, van Diest, Paul, Verhaar, Marianne C, Lam, Eric W-F, Mokry, Michal, Coffer, Paul J
Publicado 2018