Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs

por Brunger, Jonathan M., Zutshi, Ananya, Willard, Vincent P., Gersbach, Charles A., Guilak, Farshid
Publicado 2017

Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport

por Shi, Yajuan, Kim, Hyosung, Hamann, Catherine A., Rhea, Elizabeth M., Brunger, Jonathan M., Lippmann, Ethan S.
Publicado 2022

Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway

por Huynh, Nguyen PT, Gloss, Catherine C, Lorentz, Jeremiah, Tang, Ruhang, Brunger, Jonathan M, McAlinden, Audrey, Zhang, Bo, Guilak, Farshid
Publicado 2020

Synergistic and tunable human gene activation by combinations of synthetic transcription factors

por Perez-Pinera, Pablo, Ousterout, David G., Brunger, Jonathan M., Farin, Alicia M., Glass, Katherine A., Guilak, Farshid, Crawford, Gregory E., Hartemink, Alexander J., Gersbach, Charles A.
Publicado 2013

A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery

por Choi, Yun-Rak, Collins, Kelsey H., Springer, Luke E., Pferdehirt, Lara, Ross, Alison K., Wu, Chia-Lung, Moutos, Franklin T., Harasymowicz, Natalia S., Brunger, Jonathan M., Pham, Christine T. N., Guilak, Farshid
Publicado 2021

Reactive astrocytes transduce inflammation in a blood-brain barrier model through a TNF-STAT3 signaling axis and secretion of alpha 1-antichymotrypsin

por Kim, Hyosung, Leng, Kun, Park, Jinhee, Sorets, Alexander G., Kim, Suil, Shostak, Alena, Embalabala, Rebecca J., Mlouk, Kate, Katdare, Ketaki A., Rose, Indigo V. L., Sturgeon, Sarah M., Neal, Emma H., Ao, Yan, Wang, Shinong, Sofroniew, Michael V., Brunger, Jonathan M., McMahon, Douglas G., Schrag, Matthew S., Kampmann, Martin, Lippmann, Ethan S.
Publicado 2022