Review of the Structural and Dynamic Mechanisms of PPARγ Partial Agonism

por Kroker, Alice J., Bruning, John B.
Publicado 2015

Targeting Unconventional Pathways in Pursuit of Novel Antifungals

por Nguyen, Stephanie, Truong, Jia Q., Bruning, John B.
Publicado 2021

The therapeutic potential of inhibiting PPARγ phosphorylation to treat type 2 diabetes

por Frkic, Rebecca L., Richter, Katharina, Bruning, John B.
Publicado 2021

warpDOCK: Large-Scale Virtual Drug Discovery Using Cloud Infrastructure

por McDougal, Daniel P., Rajapaksha, Harinda, Pederick, Jordan L., Bruning, John B.
Publicado 2023

Human Variants in the Neuronal Basic Helix-Loop-Helix/Per-Arnt-Sim (bHLH/PAS) Transcription Factor Complex NPAS4/ARNT2 Disrupt Function

por Bersten, David C., Bruning, John B., Peet, Daniel J., Whitelaw, Murray L.
Publicado 2014

New insights into the evolutionary history of plant sorbitol dehydrogenase

por Jia, Yong, Wong, Darren CJ, Sweetman, Crystal, Bruning, John B, Ford, Christopher M
Publicado 2015

Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from Aspergillus fumigatus

por Vandborg, Bethiney C., Horsfall, Aimee J., Pederick, Jordan L., Abell, Andrew D., Bruning, John B.
Publicado 2023

Investigating the Active Oxidants Involved in Cytochrome P450 Catalyzed Sulfoxidation Reactions

por Podgorski, Matthew N., Coleman, Tom, Churchman, Luke R., Bruning, John B., De Voss, James J., Bell, Stephen G.
Publicado 2022

Unlocking the PIP-box: A peptide library reveals interactions that drive high-affinity binding to human PCNA

por Horsfall, Aimee J., Vandborg, Beth A., Kowalczyk, Wioleta, Chav, Theresa, Scanlon, Denis B., Abell, Andrew D., Bruning, John B.
Publicado 2021

Discovery of an ʟ-amino acid ligase implicated in Staphylococcal sulfur amino acid metabolism

por Pederick, Jordan L., Horsfall, Aimee J., Jovcevski‬, Blagojce, Klose, Jack, Abell, Andrew D., Pukala, Tara L., Bruning, John B.
Publicado 2022

PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix

por Frkic, Rebecca L., Marshall, Andrew C., Blayo, Anne-Laure, Pukala, Tara L., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

Structural and Dynamic Elucidation of a Non-acid PPARγ Partial Agonist: SR1988

por Frkic, Rebecca L., Chua, Benjamin S., Shin, Youseung, Pascal, Bruce D., Novick, Scott J., Kamenecka, Theodore M., Griffin, Patrick R., Bruning, John B.
Publicado 2018

An aldo-keto reductase with 2-keto-l-gulonate reductase activity functions in l-tartaric acid biosynthesis from vitamin C in Vitis vinifera

por Jia, Yong, Burbidge, Crista A., Sweetman, Crystal, Schutz, Emi, Soole, Kathy, Jenkins, Colin, Hancock, Robert D., Bruning, John B., Ford, Christopher M.
Publicado 2019

Acquired JAK2 mutations confer resistance to JAK inhibitors in cell models of acute lymphoblastic leukemia

por Downes, Charlotte E. J., McClure, Barbara J., Bruning, John B., Page, Elyse, Breen, James, Rehn, Jacqueline, Yeung, David T., White, Deborah L.
Publicado 2021

A cell permeable bimane-constrained PCNA-interacting peptide

por Horsfall, Aimee J., Vandborg, Beth A., Kikhtyak, Zoya, Scanlon, Denis B., Tilley, Wayne D., Hickey, Theresa E., Bruning, John B., Abell, Andrew D.
Publicado 2021

JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies

por Downes, Charlotte EJ., McClure, Barbara J., McDougal, Daniel P., Heatley, Susan L., Bruning, John B., Thomas, Daniel, Yeung, David T., White, Deborah L.
Publicado 2022

Proteoliposomes reconstituted with human aquaporin-1 reveal novel single-ion-channel properties

por Henderson, Sam W., Nakayama, Yoshitaka, Whitelaw, Murray L., Bruning, John B., Anderson, Peter A., Tyerman, Stephen D., Ramesh, Sunita A., Martinac, Boris, Yool, Andrea J.
Publicado 2023

Characterization of functionally deficient SIM2 variants found in patients with neurological phenotypes

por Button, Emily L., Rossi, Joseph J., McDougal, Daniel P., Bruning, John B., Peet, Daniel J., Bersten, David C., Rosenfeld, Jill A., Whitelaw, Murray L.
Publicado 2022

Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation

por Coleman, Tom, Doherty, Daniel Z., Zhang, Ting, Podgorski, Matthew N., Qiao, Ruihong, Lee, Joel H. Z., Bruning, John B., De Voss, James J., Zhou, Weihong, Bell, Stephen G.
Publicado 2022

Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

por Bruning, John B., Parent, Alex A., Gil, German, Zhao, Min, Nowak, Jason, Pace, Margaret C., Smith, Carolyn L., Afonine, Pavel V., Adams, Paul D., Katzenellenbogen, John A., Nettles, Kendall W.
Publicado 2010