Crystal Structures of Histone and p53 Methyltransferase SmyD2 Reveal a Conformational Flexibility of the Autoinhibitory C-Terminal Domain

por Jiang, Yuanyuan, Sirinupong, Nualpun, Brunzelle, Joseph, Yang, Zhe
Publicado 2011

Structural insight into nucleotide recognition by human death-associated protein kinase

por McNamara, Laurie K., Watterson, D. Martin, Brunzelle, Joseph S.
Publicado 2009

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases

por Zhang, Pamela, Lee, Hwabin, Brunzelle, Joseph S., Couture, Jean-Francois
Publicado 2012

Chaperones of F(1)-ATPase

por Ludlam, Anthony, Brunzelle, Joseph, Pribyl, Thomas, Xu, Xingjue, Gatti, Domenico L., Ackerman, Sharon H.
Publicado 2009

Characterization of the Deoxynucleotide Triphosphate Triphosphohydrolase (dNTPase) Activity of the EF1143 Protein from Enterococcus faecalis and Crystal Structure of the Activator-...

por Vorontsov, Ivan I., Minasov, George, Kiryukhina, Olga, Brunzelle, Joseph S., Shuvalova, Ludmilla, Anderson, Wayne F.
Publicado 2011

Functional insights into the interplay between DNA interaction and metal coordination in ferric uptake regulators

por Sarvan, Sabina, Charih, François, Askoura, Momen, Butcher, James, Brunzelle, Joseph S., Stintzi, Alain, Couture, Jean-François
Publicado 2018

Structural basis for recognition of diverse transcriptional repressors by the TOPLESS family of corepressors

por Ke, Jiyuan, Ma, Honglei, Gu, Xin, Thelen, Adam, Brunzelle, Joseph S., Li, Jiayang, Xu, H. Eric, Melcher, Karsten
Publicado 2015

High-resolution structures of the SARS-CoV-2 2’-O-methyltransferase reveal strategies for structure-based inhibitor design

por Rosas-Lemus, Monica, Minasov, George, Shuvalova, Ludmilla, Inniss, Nicole, Kiryukhina, Olga, Brunzelle, Joseph, Satchell, Karla J. F.
Publicado 2020

Higher Desolvation Energy Reduces Molecular Recognition in Multi-Drug Resistant HIV-1 Protease

por Wang, Yong, Dewdney, Tamaria G., Liu, Zhigang, Reiter, Samuel J., Brunzelle, Joseph S., Kovari, Iulia A., Kovari, Ladislau C.
Publicado 2012

A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation

por Zhang, Pamela, Chaturvedi, Chandra-Prakash, Tremblay, Veronique, Cramet, Myriam, Brunzelle, Joseph S., Skiniotis, Georgios, Brand, Marjorie, Shilatifard, Ali, Couture, Jean-François
Publicado 2015

Structural Insights into Neutrophilic Migration Revealed by the Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of NHERF1

por Lu, Guorong, Wu, Yanning, Jiang, Yuanyuan, Wang, Shuo, Hou, Yuning, Guan, Xiaoqing, Brunzelle, Joseph, Sirinupong, Nualpun, Sheng, Shijie, Li, Chunying, Yang, Zhe
Publicado 2013

The mononuclear metal center of type-I dihydroorotase from aquifex aeolicus

por Edwards, Brian FP, Fernando, Roshini, Martin, Philip D, Grimley, Edward, Cordes, Melissa, Vaishnav, Asmita, Brunzelle, Joseph S, Evans, Hedeel Guy, Evans, David R
Publicado 2013

Crystal structure of the trithorax group protein Ash2L reveals a Forkhead-like DNA binding domain

por Sarvan, Sabina, Avdic, Vanja, Tremblay, Véronique, Chaturvedi, Chandra-Prakash, Zhang, Pamela, Lanouette, Sylvain, Blais, Alexandre, Brunzelle, Joseph S., Brand, Marjorie, Couture, Jean-François
Publicado 2011

Structural basis of Fusarium myosin I inhibition by phenamacril

por Zhou, Yuxin, Zhou, X. Edward, Gong, Yuanping, Zhu, Yuanye, Cao, Xiaoman, Brunzelle, Joseph S., Xu, H. Eric, Zhou, Mingguo, Melcher, Karsten, Zhang, Feng
Publicado 2020

A non-canonical monovalent zinc finger stabilizes the integration of Cfp1 into the H3K4 methyltransferase complex COMPASS

por Yang, Yidai, Joshi, Monika, Takahashi, Yoh-hei, Ning, Zhibin, Qu, Qianhui, Brunzelle, Joseph S, Skiniotis, Georgios, Figeys, Daniel, Shilatifard, Ali, Couture, Jean-François
Publicado 2020

Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5

por Zhu, Guangyu, Chen, Jia, Liu, Jay, Brunzelle, Joseph S, Huang, Bo, Wakeham, Nancy, Terzyan, Simon, Li, Xuemei, Rao, Zihe, Li, Guangpu, Zhang, Xuejun C
Publicado 2007

New Conformational State of NHERF1-CXCR2 Signaling Complex Captured by Crystal Lattice Trapping

por Jiang, Yuanyuan, Lu, Guorong, Trescott, Laura R., Hou, Yuning, Guan, Xiaoqing, Wang, Shuo, Stamenkovich, Angelique, Brunzelle, Joseph, Sirinupong, Nualpun, Li, Chunying, Yang, Zhe
Publicado 2013

Mn(2+) coordinates Cap-0-RNA to align substrates for efficient 2′-O-methyl transfer by SARS-CoV-2 nsp16

por Minasov, George, Rosas-Lemus, Monica, Shuvalova, Ludmilla, Inniss, Nicole L., Brunzelle, Joseph S., Daczkowski, Courtney M., Hoover, Paul, Mesecar, Andrew D., Satchell, Karla J. F.
Publicado 2021

Structure and Enzymatic Activity of an Intellectual Disability-Associated Ornithine Decarboxylase Variant, G84R

por Zhou, X. Edward, Schultz, Chad R., Suino Powell, Kelly, Henrickson, Amy, Lamp, Jared, Brunzelle, Joseph S., Demeler, Borries, Vega, Irving E., Bachmann, André S., Melcher, Karsten
Publicado 2022

Molecular basis for the methylation specificity of ATXR5 for histone H3

por Bergamin, Elisa, Sarvan, Sabina, Malette, Josée, Eram, Mohammad S., Yeung, Sylvain, Mongeon, Vanessa, Joshi, Monika, Brunzelle, Joseph S., Michaels, Scott D., Blais, Alexandre, Vedadi, Masoud, Couture, Jean-François
Publicado 2017