Intersectin 1 is required for neuroblastoma tumorigenesis

por Russo, Angela, O'Bryan, John P.
Publicado 2012

Emerging Roles for Intersectin (ITSN) in Regulating Signaling and Disease Pathways

por Hunter, Michael P., Russo, Angela, O’Bryan, John P.
Publicado 2013

Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

por Khan, Imran, Spencer-Smith, Russell, O’Bryan, John P.
Publicado 2018

Optimization-based decoding of Imaging Spatial Transcriptomics data

por Bryan, John P, Binan, Loïc, McCann, Cai, Eldar, Yonina C, Farhi, Samouil L, Cleary, Brian
Publicado 2023

Cardiac-Specific Expression of the Tetracycline Transactivator Confers Increased Heart Function and Survival Following Ischemia Reperfusion Injury

por Elsherif, Laila, Wang, Xuerong, Grachoff, Milana, Wolska, Beata M., Geenen, David L., O'Bryan, John P.
Publicado 2012

A New Dimension to Ras Function: A Novel Role for Nucleotide-Free Ras in Class II Phosphatidylinositol 3-Kinase Beta (PI3KC2β) Regulation

por Wong, Katy A., Russo, Angela, Wang, Xuerong, Chen, Yun-Ju, Lavie, Arnon, O'Bryan, John P.
Publicado 2012

Protein Kinase A (PKA) Phosphorylation of Shp2 Protein Inhibits Its Phosphatase Activity and Modulates Ligand Specificity

por Burmeister, Brian T., Wang, Li, Gold, Matthew G., Skidgel, Randal A., O'Bryan, John P., Carnegie, Graeme K.
Publicado 2015

Mutations in the α4-α5 allosteric lobe of RAS do not significantly impair RAS signaling or self-association

por Whaby, Michael, Wallon, Lauren, Mazzei, Megan, Khan, Imran, Teng, Kai Wen, Koide, Shohei, O’Bryan, John P.
Publicado 2022

Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket

por Wallon, Lauren, Khan, Imran, Teng, Kai Wen, Koide, Akiko, Zuberi, Mariyam, Li, Jianping, Ketavarapu, Gayatri, Traaseth, Nathaniel J., O’Bryan, John P., Koide, Shohei
Publicado 2022

Intersectin (ITSN) Family of Scaffolds Function as Molecular Hubs in Protein Interaction Networks

por Wong, Katy A., Wilson, Jessica, Russo, Angela, Wang, Li, Okur, Mustafa Nazir, Wang, Xuerong, Martin, Negin P., Scappini, Erica, Carnegie, Graeme K., O'Bryan, John P.
Publicado 2012

Selective and noncovalent targeting of RAS mutants for inhibition and degradation

por Teng, Kai Wen, Tsai, Steven T., Hattori, Takamitsu, Fedele, Carmine, Koide, Akiko, Yang, Chao, Hou, Xuben, Zhang, Yingkai, Neel, Benjamin G., O’Bryan, John P., Koide, Shohei
Publicado 2021

The P-type ATPase transporter ATP7A promotes angiogenesis by limiting autophagic degradation of VEGFR2

por Ash, Dipankar, Sudhahar, Varadarajan, Youn, Seock-Won, Okur, Mustafa Nazir, Das, Archita, O’Bryan, John P., McMenamin, Maggie, Hou, Yali, Kaplan, Jack H., Fukai, Tohru, Ushio-Fukai, Masuko
Publicado 2021

Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants

por Khan, Imran, Koide, Akiko, Zuberi, Mariyam, Ketavarapu, Gayatri, Denbaum, Eric, Teng, Kai Wen, Rhett, J. Matthew, Spencer-Smith, Russell, Hobbs, G. Aaron, Camp, Ernest Ramsay, Koide, Shohei, O’Bryan, John P.
Publicado 2022

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors

por Akkapeddi, Padma, Hattori, Takamitsu, Khan, Imran, Glasser, Eliezra, Koide, Akiko, Ketavarapu, Gayatri, Whaby, Michael, Zuberi, Mariyam, Teng, Kai Wen, Lefler, Julia, Maso, Lorenzo, Bang, Injin, Ostrowski, Michael C., O’Bryan, John P., Koide, Shohei
Publicado 2023

Ceramide synthase 6 impacts T-cell allogeneic response and graft-versus-host disease through regulating N-RAS/ERK Pathway

por Sofi, M.Hanief, Tian, Linlu, Schutt, Steven, Khan, Imran, Choi, Hee-Jin, Wu, Yongxia, Bastian, David, Ticer, Taylor, Kassir, Mohamed Faisal, Atilgan, Firdevs Cansu, Kim, Jisun, Sui, Xiaohui, Zivkovic, Aleksandra, Mehrotra, Shikhar, O’Bryan, John P., Stark, Holger, Martin, Paul J., Ogretmen, Besim, Yu, Xue-Zhong
Publicado 2022