Structural and Biological Features of G-Quadruplex Aptamers as Promising Inhibitors of the STAT3 Signaling Pathway

por Esposito, Veronica, Benigno, Daniela, Bello, Ivana, Panza, Elisabetta, Bucci, Mariarosaria, Virgilio, Antonella, Galeone, Aldo
Publicado 2023

Improving the Biological Properties of Thrombin-Binding Aptamer by Incorporation of 8-Bromo-2′-Deoxyguanosine and 2′-Substituted RNA Analogues

por Virgilio, Antonella, Benigno, Daniela, Aliberti, Carla, Vellecco, Valentina, Bucci, Mariarosaria, Esposito, Veronica, Galeone, Aldo
Publicado 2023

Investigating the properties of TBA variants with twin thrombin binding domains

por Amato, Teresa, Virgilio, Antonella, Pirone, Luciano, Vellecco, Valentina, Bucci, Mariarosaria, Pedone, Emilia, Esposito, Veronica, Galeone, Aldo
Publicado 2019

Perthamide C Inhibits eNOS and iNOS Expression and Has Immunomodulating Activity In Vivo

por Bucci, Mariarosaria, Cantalupo, Anna, Vellecco, Valentina, Panza, Elisabetta, Monti, Maria Chiara, Zampella, Angela, Ianaro, Angela, Cirino, Giuseppe
Publicado 2013

Erucin, an H(2)S-Releasing Isothiocyanate, Exerts Anticancer Effects in Human Triple-Negative Breast Cancer Cells Triggering Autophagy-Dependent Apoptotic Cell Death

por Bello, Ivana, Smimmo, Martina, d’Emmanuele di Villa Bianca, Roberta, Bucci, Mariarosaria, Cirino, Giuseppe, Panza, Elisabetta, Brancaleone, Vincenzo
Publicado 2023

A new modified thrombin binding aptamer containing a 5′–5′ inversion of polarity site

por Martino, Luigi, Virno, Ada, Randazzo, Antonio, Virgilio, Antonella, Esposito, Veronica, Giancola, Concetta, Bucci, Mariarosaria, Cirino, Giuseppe, Mayol, Luciano
Publicado 2006

Structural properties and anticoagulant/cytotoxic activities of heterochiral enantiomeric thrombin binding aptamer (TBA) derivatives

por Virgilio, Antonella, Esposito, Veronica, Pecoraro, Annalisa, Russo, Annapina, Vellecco, Valentina, Pepe, Antonietta, Bucci, Mariarosaria, Russo, Giulia, Galeone, Aldo
Publicado 2020

Interleukin-17A (IL-17A): A silent amplifier of COVID-19

por Maione, Francesco, Casillo, Gian Marco, Raucci, Federica, Salvatore, Cristian, Ambrosini, Giovanna, Costa, Luisa, Scarpa, Raffaele, Caso, Francesco, Bucci, Mariarosaria
Publicado 2021

CTH/MPST double ablation results in enhanced vasorelaxation and reduced blood pressure via upregulation of the eNOS/sGC pathway

por Katsouda, Antonia, Markou, Maria, Zampas, Paraskevas, Varela, Aimilia, Davos, Constantinos H., Vellecco, Valentina, Cirino, Giuseppe, Bucci, Mariarosaria, Papapetropoulos, Andreas
Publicado 2023

Properties and Potential Antiproliferative Activity of Thrombin-Binding Aptamer (TBA) Derivatives with One or Two Additional G-Tetrads

por Benigno, Daniela, Virgilio, Antonella, Bello, Ivana, La Manna, Sara, Vellecco, Valentina, Bucci, Mariarosaria, Marasco, Daniela, Panza, Elisabetta, Esposito, Veronica, Galeone, Aldo
Publicado 2022

Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity

por Virgilio, Antonella, Petraccone, Luigi, Vellecco, Valentina, Bucci, Mariarosaria, Varra, Michela, Irace, Carlo, Santamaria, Rita, Pepe, Antonietta, Mayol, Luciano, Esposito, Veronica, Galeone, Aldo
Publicado 2015

cGMP-Dependent Protein Kinase Contributes to Hydrogen Sulfide-Stimulated Vasorelaxation

por Bucci, Mariarosaria, Papapetropoulos, Andreas, Vellecco, Valentina, Zhou, Zongmin, Zaid, Altaany, Giannogonas, Panagiotis, Cantalupo, Anna, Dhayade, Sandeep, Karalis, Katia P., Wang, Rui, Feil, Robert, Cirino, Giuseppe
Publicado 2012

Site specific replacements of a single loop nucleoside with a dibenzyl linker may switch the activity of TBA from anticoagulant to antiproliferative

por Scuotto, Maria, Rivieccio, Elisa, Varone, Alessia, Corda, Daniela, Bucci, Mariarosaria, Vellecco, Valentina, Cirino, Giuseppe, Virgilio, Antonella, Esposito, Veronica, Galeone, Aldo, Borbone, Nicola, Varra, Michela, Mayol, Luciano
Publicado 2015

Fragment-based de novo design of a cystathionine γ-lyase selective inhibitor blocking hydrogen sulfide production

por Corvino, Angela, Severino, Beatrice, Fiorino, Ferdinando, Frecentese, Francesco, Magli, Elisa, Perissutti, Elisa, Santagada, Vincenzo, Bucci, Mariarosaria, Cirino, Giuseppe, Kelly, Geoff, Servillo, Luigi, Popowicz, Grzegorz, Pastore, Annalisa, Caliendo, Giuseppe
Publicado 2016

Hydrogen sulfide donor AP123 restores endothelial nitric oxide-dependent vascular function in hyperglycemia via a CREB-dependent pathway

por Montanaro, Rosangela, Vellecco, Valentina, Torregrossa, Roberta, Casillo, Gian Marco, Manzo, Onorina Laura, Mitidieri, Emma, Bucci, Mariarosaria, Castaldo, Sigismondo, Sorrentino, Raffaella, Whiteman, Matthew, Smimmo, Martina, Carriero, Flavia, Terrazzano, Giuseppe, Cirino, Giuseppe, d’Emmanuele di Villa Bianca, Roberta, Brancaleone, Vincenzo
Publicado 2023

Involvement of 3′,5′‐cyclic inosine monophosphate in cystathionine γ‐lyase‐dependent regulation of the vascular tone

por Mitidieri, Emma, Vellecco, Valentina, Brancaleone, Vincenzo, Vanacore, Domenico, Manzo, Onorina L., Martin, Emil, Sharina, Iraida, Krutsenko, Yekaterina, Monti, Maria Chiara, Morretta, Elva, Papapetropoulos, Andreas, Caliendo, Giuseppe, Frecentese, Francesco, Cirino, Giuseppe, Sorrentino, Raffaella, d'Emmanuele di Villa Bianca, Roberta, Bucci, Mariarosaria
Publicado 2021

New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function

por Saviano, Anella, Manosour, Adel Abo, Raucci, Federica, Merlino, Francesco, Marigliano, Noemi, Schettino, Anna, Wahid, Mussarat, Begum, Jenefa, Filer, Andrew, Manning, Julia E, Casillo, Gian Marco, Piccolo, Marialuisa, Ferraro, Maria Grazia, Marzano, Simona, Russomanno, Pasquale, Bellavita, Rosa, Irace, Carlo, Amato, Jussara, Alfaifi, Mohammed, Rimmer, Peter, Iqbal, Tariq, Pieretti, Stefano, Vellecco, Valentina, Caso, Francesco, Costa, Luisa, Giacomelli, Roberto, Scarpa, Raffaele, Cirino, Giuseppe, Bucci, Mariarosaria, McGettrick, Helen M, Grieco, Paolo, Iqbal, Asif Jilani, Maione, Francesco
Publicado 2023