For Better or Worse: The Potential for Dose Limiting the On-Target Toxicity of PI 3-Kinase Inhibitors

por Buchanan, Christina M., Lee, Kate L., Shepherd, Peter R.
Publicado 2019

Enzyme activity effects of N-terminal His-tag attached to catalytic sub-unit of phosphoinositide-3-kinase

por Dickson, James M. J., Lee, Woo-Jeong, Shepherd, Peter R., Buchanan, Christina M.
Publicado 2013

Response to BRAF-targeted Therapy Is Enhanced by Cotargeting VEGFRs or WNT/β-Catenin Signaling in BRAF-mutant Colorectal Cancer Models

por Tran, Khanh B., Kolekar, Sharada, Wang, Qian, Shih, Jen-Hsing, Buchanan, Christina M., Deva, Sanjeev, Shepherd, Peter R.
Publicado 2022

Preptin Deficiency Does Not Protect against High‐Fat Diet‐Induced Metabolic Dysfunction or Bone Loss in Mice

por Buckels, Emma J., Tan, Joey, Hsu, Huai‐Ling, Zhu, Yuting, Buchanan, Christina M., Matthews, Brya G., Lee, Kate L.
Publicado 2023

Oncogenic Mutations of p110α Isoform of PI 3-Kinase Upregulate Its Protein Kinase Activity

por Buchanan, Christina M., Dickson, James M. J., Lee, Woo-Jeong, Guthridge, Mark A., Kendall, Jackie D., Shepherd, Peter R.
Publicado 2013

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors

por Rewcastle, Gordon W, Kolekar, Sharada, Buchanan, Christina M, Gamage, Swarna A, Giddens, Anna C, Tsang, Kit Y, Kendall, Jackie D, Singh, Ripudaman, Lee, Woo-Jeong, Smith, Greg C, Han, Weiping, Matthews, David J, Denny, William A, Shepherd, Peter R, Jamieson, Stephen M.F
Publicado 2017