Recombinant Adeno-Associated Viral Vectors (rAAV)-Vector Elements in Ocular Gene Therapy Clinical Trials and Transgene Expression and Bioactivity Assays

por Buck, Thilo M., Wijnholds, Jan
Publicado 2020

AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

por Buck, Thilo M., Vos, Rogier M., Alves, C. Henrique, Wijnholds, Jan
Publicado 2020

Sleep Deprivation Does not Change the Flash Electroretinogram in Wild-type and Opn4(−/−)Gnat1(−/−) Mice

por Schoonderwoerd, Robin A., Buck, Thilo M., Andriessen, Charlotte A., Wijnholds, Jan, Hattar, Samer, Meijer, Johanna H., Deboer, Tom
Publicado 2022

AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype

por Boon, Nanda, Lu, Xuefei, Andriessen, Charlotte A., Moustakas, Ioannis, Buck, Thilo M., Freund, Christian, Arendzen, Christiaan H., Böhringer, Stefan, Mei, Hailiang, Wijnholds, Jan
Publicado 2023

AAV-mediated gene augmentation therapy of CRB1 patient-derived retinal organoids restores the histological and transcriptional retinal phenotype

por Boon, Nanda, Lu, Xuefei, Andriessen, Charlotte A., Moustakas, Ioannis, Buck, Thilo M., Freund, Christian, Arendzen, Christiaan H., Böhringer, Stefan, Boon, Camiel J.F., Mei, Hailiang, Wijnholds, Jan
Publicado 2023

Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1

por Boon, Nanda, Alves, C. Henrique, Mulder, Aat A., Andriessen, Charlotte A., Buck, Thilo M., Quinn, Peter M. J., Vos, Rogier M., Koster, Abraham J., Jost, Carolina R., Wijnholds, Jan
Publicado 2021

CRB1 is required for recycling by RAB11A+ vesicles in human retinal organoids

por Buck, Thilo M., Quinn, Peter M.J., Pellissier, Lucie P., Mulder, Aat A., Jongejan, Aldo, Lu, Xuefei, Boon, Nanda, Koot, Daniëlle, Almushattat, Hind, Arendzen, Christiaan H., Vos, Rogier M., Bradley, Edward J., Freund, Christian, Mikkers, Harald M.M., Boon, Camiel J.F., Moerland, Perry D., Baas, Frank, Koster, Abraham J., Neefjes, Jacques, Berlin, Ilana, Jost, Carolina R., Wijnholds, Jan
Publicado 2023

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5

por Quinn, Peter M., Buck, Thilo M., Mulder, Aat A., Ohonin, Charlotte, Alves, C. Henrique, Vos, Rogier M., Bialecka, Monika, van Herwaarden, Tessa, van Dijk, Elon H.C., Talib, Mays, Freund, Christian, Mikkers, Harald M.M., Hoeben, Rob C., Goumans, Marie-José, Boon, Camiel J.F., Koster, Abraham J., Chuva de Sousa Lopes, Susana M., Jost, Carolina R., Wijnholds, Jan
Publicado 2019