Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition

por Popova, Semiramis A., Buczacki, Simon J. A.
Publicado 2018

Mouse models of colorectal cancer as preclinical models

por McIntyre, Rebecca E., Buczacki, Simon J.A., Arends, Mark J., Adams, David J.
Publicado 2015

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation

por Uribe-Lewis, Santiago, Carroll, Thomas, Menon, Suraj, Nicholson, Anna, Manasterski, Piotr J., Winton, Douglas J., Buczacki, Simon J. A., Murrell, Adele
Publicado 2020

Itraconazole targets cell cycle heterogeneity in colorectal cancer

por Buczacki, Simon J.A., Popova, Semiramis, Biggs, Emma, Koukorava, Chrysa, Buzzelli, Jon, Vermeulen, Louis, Hazelwood, Lee, Francies, Hayley, Garnett, Mathew J., Winton, Douglas J.
Publicado 2018

Isolation of Human Colon Stem Cells Using Surface Expression of PTK7

por Jung, Peter, Sommer, Christian, Barriga, Francisco M., Buczacki, Simon J., Hernando-Momblona, Xavier, Sevillano, Marta, Duran-Frigola, Miquel, Aloy, Patrick, Selbach, Matthias, Winton, Douglas J., Batlle, Eduard
Publicado 2015

Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

por Moad, Mohammad, Hannezo, Edouard, Buczacki, Simon J., Wilson, Laura, El-Sherif, Amira, Sims, David, Pickard, Robert, Wright, Nicholas A., Williamson, Stuart C., Turnbull, Doug M., Taylor, Robert W., Greaves, Laura, Robson, Craig N., Simons, Benjamin D., Heer, Rakesh
Publicado 2017

An innate IL-25-ILC2-MDSC axis creates a cancer-permissive microenvironment for Apc-mutation-driven intestinal tumorigenesis

por Jou, Eric, Rodriguez-Rodriguez, Noe, Ferreira, Ana-Carolina F., Jolin, Helen E., Clark, Paula A., Sawmynaden, Kovilen, Ko, Michelle, Murphy, Jane E., Mannion, Jonathan, Ward, Christopher, Matthews, David J., Buczacki, Simon J. A., McKenzie, Andrew N. J.
Publicado 2022

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

por Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Publicado 2022

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

por Robinson, Philip S., Thomas, Laura E., Abascal, Federico, Jung, Hyunchul, Harvey, Luke M. R., West, Hannah D., Olafsson, Sigurgeir, Lee, Bernard C. H., Coorens, Tim H. H., Lee-Six, Henry, Butlin, Laura, Lander, Nicola, Truscott, Rebekah, Sanders, Mathijs A., Lensing, Stefanie V., Buczacki, Simon J. A., ten Hoopen, Rogier, Coleman, Nicholas, Brunton-Sim, Roxanne, Rushbrook, Simon, Saeb-Parsy, Kourosh, Lalloo, Fiona, Campbell, Peter J., Martincorena, Iñigo, Sampson, Julian R., Stratton, Michael R.
Publicado 2022

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

por Beach, Callum, MacLean, David, Majorova, Dominika, Melemenidis, Stavros, Nambiar, Dhanya K., Kim, Ryan K., Valbuena, Gabriel N., Guglietta, Silvia, Krieg, Carsten, Darvish-Damavandi, Mahnaz, Suwa, Tatsuya, Easton, Alistair, Hillson, Lily V.S., McCulloch, Ashley K., McMahon, Ross K., Pennel, Kathryn, Edwards, Joanne, O’Cathail, Sean M., Roxburgh, Campbell S., Domingo, Enric, Moon, Eui Jung, Jiang, Dadi, Jiang, Yanyan, Zhang, Qingyang, Koong, Albert C., Woodruff, Trent M., Graves, Edward E., Maughan, Tim, Buczacki, Simon J.A., Stucki, Manuel, Le, Quynh-Thu, Leedham, Simon J., Giaccia, Amato J., Olcina, Monica M.
Publicado 2023

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2

por Brevini, Teresa, Maes, Mailis, Webb, Gwilym J., John, Binu V., Fuchs, Claudia D., Buescher, Gustav, Wang, Lu, Griffiths, Chelsea, Brown, Marnie L., Scott, William E., Pereyra-Gerber, Pehuén, Gelson, William T. H., Brown, Stephanie, Dillon, Scott, Muraro, Daniele, Sharp, Jo, Neary, Megan, Box, Helen, Tatham, Lee, Stewart, James, Curley, Paul, Pertinez, Henry, Forrest, Sally, Mlcochova, Petra, Varankar, Sagar S., Darvish-Damavandi, Mahnaz, Mulcahy, Victoria L., Kuc, Rhoda E., Williams, Thomas L., Heslop, James A., Rossetti, Davide, Tysoe, Olivia C., Galanakis, Vasileios, Vila-Gonzalez, Marta, Crozier, Thomas W. M., Bargehr, Johannes, Sinha, Sanjay, Upponi, Sara S., Fear, Corrina, Swift, Lisa, Saeb-Parsy, Kourosh, Davies, Susan E., Wester, Axel, Hagström, Hannes, Melum, Espen, Clements, Darran, Humphreys, Peter, Herriott, Jo, Kijak, Edyta, Cox, Helen, Bramwell, Chloe, Valentijn, Anthony, Illingworth, Christopher J. R., Dahman, Bassam, Bastaich, Dustin R., Ferreira, Raphaella D., Marjot, Thomas, Barnes, Eleanor, Moon, Andrew M., Barritt, Alfred S., Gupta, Ravindra K., Baker, Stephen, Davenport, Anthony P., Corbett, Gareth, Gorgoulis, Vassilis G., Buczacki, Simon J. A., Lee, Joo-Hyeon, Matheson, Nicholas J., Trauner, Michael, Fisher, Andrew J., Gibbs, Paul, Butler, Andrew J., Watson, Christopher J. E., Mells, George F., Dougan, Gordon, Owen, Andrew, Lohse, Ansgar W., Vallier, Ludovic, Sampaziotis, Fotios
Publicado 2022