Human Antibody Production in Transgenic Animals

por Brüggemann, Marianne, Osborn, Michael J., Ma, Biao, Hayre, Jasvinder, Avis, Suzanne, Lundstrom, Brian, Buelow, Roland
Publicado 2014

Antigen-specific single B cell sorting and expression-cloning from immunoglobulin humanized rats: a rapid and versatile method for the generation of high affinity and discriminativ...

por Ouisse, Laure-Hélène, Gautreau-Rolland, Laetitia, Devilder, Marie-Claire, Osborn, Michael, Moyon, Melinda, Visentin, Jonathan, Halary, Frank, Bruggemann, Marianne, Buelow, Roland, Anegon, Ignacio, Saulquin, Xavier
Publicado 2017

Efficient gene targeting by homology-directed repair in rat zygotes using TALE nucleases

por Remy, Séverine, Tesson, Laurent, Menoret, Séverine, Usal, Claire, De Cian, Anne, Thepenier, Virginie, Thinard, Reynald, Baron, Daniel, Charpentier, Marine, Renaud, Jean-Baptiste, Buelow, Roland, Cost, Gregory J., Giovannangeli, Carine, Fraichard, Alexandre, Concordet, Jean-Paul, Anegon, Ignacio
Publicado 2014

TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL

por Malik-Chaudhry, Harbani K., Prabhakar, Kirthana, Ugamraj, Harshad S., Boudreau, Andrew A., Buelow, Benjamin, Dang, Kevin, Davison, Laura M., Harris, Katherine E., Jorgensen, Brett, Ogana, Heather, Pham, Duy, Schellenberger, Ute, Van Schooten, Wim, Buelow, Roland, Iyer, Suhasini, Trinklein, Nathan D., Rangaswamy, Udaya S.
Publicado 2021

Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies

por Trinklein, Nathan D., Pham, Duy, Schellenberger, Ute, Buelow, Ben, Boudreau, Andrew, Choudhry, Priya, Clarke, Starlynn C., Dang, Kevin, Harris, Katherine E., Iyer, Suhasini, Jorgensen, Brett, Pratap, Payal P., Rangaswamy, Udaya S., Ugamraj, Harshad S., Vafa, Omid, Wiita, Arun P., van Schooten, Wim, Buelow, Roland, Force Aldred, Shelley
Publicado 2019

Rabbits transgenic for human IgG genes recapitulating rabbit B-cell biology to generate human antibodies of high specificity and affinity

por Ros, Francesca, Offner, Sonja, Klostermann, Stefan, Thorey, Irmgard, Niersbach, Helmut, Breuer, Sebastian, Zarnt, Grit, Lorenz, Stefan, Puels, Juergen, Siewe, Basile, Schueler, Nicole, Dragicevic, Tajana, Ostler, Dominique, Hansen-Wester, Imke, Lifke, Valeria, Kaluza, Brigitte, Kaluza, Klaus, van Schooten, Wim, Buelow, Roland, Tissot, Alain C, Platzer, Josef
Publicado 2020

TNB-738, a biparatopic antibody, boosts intracellular NAD+ by inhibiting CD38 ecto-enzyme activity

por Ugamraj, Harshad S., Dang, Kevin, Ouisse, Laure-Hélène, Buelow, Benjamin, Chini, Eduardo N., Castello, Giulia, Allison, James, Clarke, Starlynn C, Davison, Laura M., Buelow, Roland, Deng, Rong, Iyer, Suhasini, Schellenberger, Ute, Manika, Sankar N., Bijpuria, Shipra, Musnier, Astrid, Poupon, Anne, Cuturi, Maria Cristina, van Schooten, Wim, Dalvi, Pranjali
Publicado 2022

Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release

por Dang, Kevin, Castello, Giulia, Clarke, Starlynn C, Li, Yuping, Balasubramani, Aarti, Boudreau, Andrew, Davison, Laura, Harris, Katherine E, Pham, Duy, Sankaran, Preethi, Ugamraj, Harshad S, Deng, Rong, Kwek, Serena, Starzinski, Alec, Iyer, Suhasini, van Schooten, Wim, Schellenberger, Ute, Sun, Wenchao, Trinklein, Nathan D, Buelow, Roland, Buelow, Ben, Fong, Lawrence, Dalvi, Pranjali
Publicado 2021

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells

por Harris, Katherine E., Lorentsen, Kyle J., Malik-Chaudhry, Harbani K., Loughlin, Kaitlyn, Basappa, Harish Medlari, Hartstein, Sharon, Ahmil, Ghenima, Allen, Nicole S., Avanzino, Brian C., Balasubramani, Aarti, Boudreau, Andrew A., Chang, Karen, Cuturi, Maria-Cristina, Davison, Laura M., Ho, Dennis M., Iyer, Suhasini, Rangaswamy, Udaya S., Sankaran, Preethi, Schellenberger, Ute, Buelow, Roland, Trinklein, Nathan D.
Publicado 2021

Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies

por Harris, Katherine E., Aldred, Shelley Force, Davison, Laura M., Ogana, Heather Anne N., Boudreau, Andrew, Brüggemann, Marianne, Osborn, Michael, Ma, Biao, Buelow, Benjamin, Clarke, Starlynn C., Dang, Kevin H., Iyer, Suhasini, Jorgensen, Brett, Pham, Duy T., Pratap, Payal P., Rangaswamy, Udaya S., Schellenberger, Ute, van Schooten, Wim C., Ugamraj, Harshad S., Vafa, Omid, Buelow, Roland, Trinklein, Nathan D.
Publicado 2018

Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies

por Clarke, Starlynn C., Ma, Biao, Trinklein, Nathan D., Schellenberger, Ute, Osborn, Michael J., Ouisse, Laure-Hélène, Boudreau, Andrew, Davison, Laura M., Harris, Katherine E., Ugamraj, Harshad S., Balasubramani, Aarti, Dang, Kevin H., Jorgensen, Brett, Ogana, Heather Anne N., Pham, Duy T., Pratap, Payal P., Sankaran, Preethi, Anegon, Ignacio, van Schooten, Wim C., Brüggemann, Marianne, Buelow, Roland, Force Aldred, Shelley
Publicado 2019

A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer

por Avanzino, Brian C., Prabhakar, Kirthana, Dalvi, Pranjali, Hartstein, Sharon, Kehm, Hannes, Balasubramani, Aarti, Boudreau, Andrew A., Buelow, Ben, Chang, Karen, Davison, Laura M., Iyer, Suhasini, Kalwit, Vidyut, Lewis Wilson, Kristin, Malik-Chaudhry, Harbani K., Pierson, Will, Pineda, Geovanni, Rangaswamy, Udaya S., Saiganesh, Sowmya, Schellenberger, Ute, Ugamraj, Harshad S., Yabut, Rodolfovan D., Buelow, Roland, Chapman, Jocelyn, Trinklein, Nathan D., Harris, Katherine E.
Publicado 2022