New insights into the interplay between the translation machinery and nonsense-mediated mRNA decay factors

por Raimondeau, Etienne, Bufton, Joshua C., Schaffitzel, Christiane
Publicado 2018

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing m...

por Bufton, Joshua C, Powers, Kyle T, Szeto, Jenn-Yeu A, Toelzer, Christine, Berger, Imre, Schaffitzel, Christiane
Publicado 2022

VLP‐factory™ and ADDomer(©): Self‐assembling Virus‐Like Particle (VLP) Technologies for Multiple Protein and Peptide Epitope Display

por Sari‐Ak, Duygu, Bufton, Joshua, Gupta, Kapil, Garzoni, Frederic, Fitzgerald, Daniel, Schaffitzel, Christiane, Berger, Imre
Publicado 2021

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

por Suebsuwong, Chalada, Pinkas, Daniel M., Ray, Soumya S., Bufton, Joshua C., Dai, Bing, Bullock, Alex N., Degterev, Alexei, Cuny, Gregory D.
Publicado 2018

Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases

por Pinkas, Daniel M., Sanvitale, Caroline E., Bufton, Joshua C., Sorrell, Fiona J., Solcan, Nicolae, Chalk, Rod, Doutch, James, Bullock, Alex N.
Publicado 2017

Inhibition of homologous phosphorolytic ribonucleases by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism

por Stone, Carlanne M., Butt, Louise E., Bufton, Joshua C., Lourenco, Daniel C., Gowers, Darren M., Pickford, Andrew R., Cox, Paul A., Vincent, Helen A., Callaghan, Anastasia J.
Publicado 2017

Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA

por Powers, Kyle T, Stevenson-Jones, Flint, Yadav, Sathish K N, Amthor, Beate, Bufton, Joshua C, Borucu, Ufuk, Shen, Dakang, Becker, Jonas P, Lavysh, Daria, Hentze, Matthias W, Kulozik, Andreas E, Neu-Yilik, Gabriele, Schaffitzel, Christiane
Publicado 2021

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

por Vragniau, Charles, Bufton, Joshua C., Garzoni, Frédéric, Stermann, Emilie, Rabi, Fruzsina, Terrat, Céline, Guidetti, Mélanie, Josserand, Véronique, Williams, Matt, Woods, Christopher J., Viedma, Gerardo, Bates, Phil, Verrier, Bernard, Chaperot, Laurence, Schaffitzel, Christiane, Berger, Imre, Fender, Pascal
Publicado 2019

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

por Hrdinka, Matous, Schlicher, Lisa, Dai, Bing, Pinkas, Daniel M, Bufton, Joshua C, Picaud, Sarah, Ward, Jennifer A, Rogers, Catherine, Suebsuwong, Chalada, Nikhar, Sameer, Cuny, Gregory D, Huber, Kilian VM, Filippakopoulos, Panagis, Bullock, Alex N, Degterev, Alexei, Gyrd‐Hansen, Mads
Publicado 2018

Target highlights in CASP13: Experimental target structures through the eyes of their authors

por Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, AK, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., Schwede, Torsten
Publicado 2019